Negative Allosteric Modulation of mGluR5 Partially Corrects Pathophysiology in a Mouse Model of Rett Syndrome

Negative Allosteric Modulation of mGluR5 Partially Corrects Pathophysiology in a Mouse Model of Rett Syndrome

Rett syndrome (RTT) is caused by mutations in the gene encoding methyl-CpG binding protein 2 (MECP2), an epigenetic regulator of mRNA transcription. Here, we report a test of the hypothesis of shared pathophysiology of RTT and fragile X, another monogenic cause of autism and intellectual disability....

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Bibliographic Details
Main Authors: Wu, Hao, Osterweil, Emily K., Zhang, Yi, Tao, Jifang, Coronado, Amanda, De Laittre, Elizabeth A., Bear, Mark
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Format: Article
Language:en_US
Published: Society for Neuroscience 2017
Online Access:http://hdl.handle.net/1721.1/110232

Internet

http://hdl.handle.net/1721.1/110232

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