In Vivo Compatibility of Graphene Oxide with Differing Oxidation States
Graphene oxide (GO) is suggested to have great potential as a component of biomedical devices. Although this nanomaterial has been demonstrated to be cytocompatible in vitro, its compatibility in vivo in tissue sites relevant for biomedical device application is yet to be fully understood. Here, we...
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| Format: | Article |
| Language: | en_US |
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American Chemical Society (ACS)
2017
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| Online Access: | http://hdl.handle.net/1721.1/110237 https://orcid.org/0000-0001-8046-2288 https://orcid.org/0000-0003-0624-3532 https://orcid.org/0000-0001-5629-4798 https://orcid.org/0000-0003-4255-0492 |
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| author | Sydlik, Stefanie Arlene Jhunjhunwala, Siddharth Webber, Matthew Anderson, Daniel Griffith Langer, Robert S |
| author2 | Massachusetts Institute of Technology. Institute for Medical Engineering & Science |
| author_facet | Massachusetts Institute of Technology. Institute for Medical Engineering & Science Sydlik, Stefanie Arlene Jhunjhunwala, Siddharth Webber, Matthew Anderson, Daniel Griffith Langer, Robert S |
| author_sort | Sydlik, Stefanie Arlene |
| collection | MIT |
| description | Graphene oxide (GO) is suggested to have great potential as a component of biomedical devices. Although this nanomaterial has been demonstrated to be cytocompatible in vitro, its compatibility in vivo in tissue sites relevant for biomedical device application is yet to be fully understood. Here, we evaluate the compatibility of GO with two different oxidation levels following implantation in subcutaneous and intraperitoneal tissue sites, which are of broad relevance for application to medical devices. We demonstrate GO to be moderately compatible in vivo in both tissue sites, with the inflammatory reaction in response to implantation consistent with a typical foreign body reaction. A reduction in the degree of GO oxidation results in faster immune cell infiltration, uptake, and clearance following both subcutaneous and peritoneal implantation. Future work toward surface modification or coating strategies could be useful to reduce the inflammatory response and improve compatibility of GO as a component of medical devices. |
| first_indexed | 2024-09-23T17:12:44Z |
| format | Article |
| id | mit-1721.1/110237 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T17:12:44Z |
| publishDate | 2017 |
| publisher | American Chemical Society (ACS) |
| record_format | dspace |
| spelling | mit-1721.1/1102372022-09-30T00:28:57Z In Vivo Compatibility of Graphene Oxide with Differing Oxidation States Sydlik, Stefanie Arlene Jhunjhunwala, Siddharth Webber, Matthew Anderson, Daniel Griffith Langer, Robert S Massachusetts Institute of Technology. Institute for Medical Engineering & Science Harvard University--MIT Division of Health Sciences and Technology Massachusetts Institute of Technology. Department of Chemical Engineering Koch Institute for Integrative Cancer Research at MIT Sydlik, Stefanie Arlene Jhunjhunwala, Siddharth Webber, Matthew Anderson, Daniel Griffith Langer, Robert S Graphene oxide (GO) is suggested to have great potential as a component of biomedical devices. Although this nanomaterial has been demonstrated to be cytocompatible in vitro, its compatibility in vivo in tissue sites relevant for biomedical device application is yet to be fully understood. Here, we evaluate the compatibility of GO with two different oxidation levels following implantation in subcutaneous and intraperitoneal tissue sites, which are of broad relevance for application to medical devices. We demonstrate GO to be moderately compatible in vivo in both tissue sites, with the inflammatory reaction in response to implantation consistent with a typical foreign body reaction. A reduction in the degree of GO oxidation results in faster immune cell infiltration, uptake, and clearance following both subcutaneous and peritoneal implantation. Future work toward surface modification or coating strategies could be useful to reduce the inflammatory response and improve compatibility of GO as a component of medical devices. National Institutes of Health (U.S.). Centers of Cancer and Nanotechnology Excellence (1U54CA151884-01) National Institutes of Health (U.S.). Ruth L. Kirschstein National Research Service Award (F32EB018155) David H. Koch Institute for Integrative Cancer Research at MIT (Mazumdar-Shaw International Oncology Fellowship) National Institutes of Health (U.S.). Ruth L. Kirschstein National Research Service Award (F32DK101335) National Institutes of Health (U.S.) (R01- DE016516-06) 2017-06-23T20:10:44Z 2017-06-23T20:10:44Z 2015-04 2014-12 Article http://purl.org/eprint/type/JournalArticle 1936-0851 1936-086X http://hdl.handle.net/1721.1/110237 Sydlik, Stefanie A. et al. “In Vivo Compatibility of Graphene Oxide with Differing Oxidation States.” ACS Nano 9.4 (2015): 3866–3874. https://orcid.org/0000-0001-8046-2288 https://orcid.org/0000-0003-0624-3532 https://orcid.org/0000-0001-5629-4798 https://orcid.org/0000-0003-4255-0492 en_US http://dx.doi.org/10.1021/acsnano.5b01290 ACS Nano Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf American Chemical Society (ACS) PMC |
| spellingShingle | Sydlik, Stefanie Arlene Jhunjhunwala, Siddharth Webber, Matthew Anderson, Daniel Griffith Langer, Robert S In Vivo Compatibility of Graphene Oxide with Differing Oxidation States |
| title | In Vivo Compatibility of Graphene Oxide with Differing Oxidation States |
| title_full | In Vivo Compatibility of Graphene Oxide with Differing Oxidation States |
| title_fullStr | In Vivo Compatibility of Graphene Oxide with Differing Oxidation States |
| title_full_unstemmed | In Vivo Compatibility of Graphene Oxide with Differing Oxidation States |
| title_short | In Vivo Compatibility of Graphene Oxide with Differing Oxidation States |
| title_sort | in vivo compatibility of graphene oxide with differing oxidation states |
| url | http://hdl.handle.net/1721.1/110237 https://orcid.org/0000-0001-8046-2288 https://orcid.org/0000-0003-0624-3532 https://orcid.org/0000-0001-5629-4798 https://orcid.org/0000-0003-4255-0492 |
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