Argonaute-Bound Small RNAs from Promoter-Proximal RNA Polymerase II

Argonaute (Ago) proteins mediate posttranscriptional gene repression by binding guide miRNAs to regulate targeted RNAs. To confidently assess Ago-bound small RNAs, we adapted a mouse embryonic stem cell system to express a single epitope-tagged Ago protein family member in an inducible manner. Here,...

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Bibliographic Details
Main Authors: Zamudio, Jesse Ray, Kelly, Timothy James, Sharp, Phillip A.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Elsevier 2017
Online Access:http://hdl.handle.net/1721.1/110327
https://orcid.org/0000-0002-3621-0144
https://orcid.org/0000-0003-1465-1691