Small-Molecule RORγt Antagonists Inhibit T Helper 17 Cell Transcriptional Network by Divergent Mechanisms

Small-Molecule RORγt Antagonists Inhibit T Helper 17 Cell Transcriptional Network by Divergent Mechanisms

We identified three retinoid-related orphan receptor gamma t (RORγt)-specific inhibitors that suppress T helper 17 (Th17) cell responses, including Th17-cell-mediated autoimmune disease. We systemically characterized RORγt binding in the presence and absence of drugs with corresponding whole-genome...

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Bibliographic Details
Main Authors: Xiao, Sheng, Yosef, Nir, Yang, Jianfei, Wang, Yonghui, Zhou, Ling, Zhu, Chen, Wu, Chuan, Baloglu, Erkan, Schmidt, Darby, Ramesh, Radha, Lobera, Mercedes, Sundrud, Mark S., Tsai, Pei-Yun, Xiang, Zhijun, Wang, Jinsong, Xu, Yan, Lin, Xichen, Kretschmer, Karsten, Rahl, Peter B., Zhong, Zhong, Hafler, David A., Ghosh, Shomir, Marson, Alexander, Kuchroo, Vijay K., Regev, Aviv, Young, Richard A.
Other Authors: Broad Institute of MIT and Harvard
Format: Article
Language:en_US
Published: Elsevier 2017
Online Access:http://hdl.handle.net/1721.1/110329
https://orcid.org/0000-0001-8567-2049
https://orcid.org/0000-0001-8855-8647

Internet

http://hdl.handle.net/1721.1/110329
https://orcid.org/0000-0001-8567-2049
https://orcid.org/0000-0001-8855-8647

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