In vitro models of the metastatic cascade: from local invasion to extravasation
A crucial event in the metastatic cascade is the extravasation of circulating cancer cells from blood capillaries to the surrounding tissues. The past 5 years have been characterized by a significant evolution in the development of in vitro extravasation models, which moved from traditional transmig...
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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Elsevier
2017
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| Online Access: | http://hdl.handle.net/1721.1/110374 https://orcid.org/0000-0002-7232-304X |
| _version_ | 1811090444229017600 |
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| author | Bersini, S. Moretti, Matteo Jeon, Jessie S Kamm, Roger Dale |
| author2 | Massachusetts Institute of Technology. Department of Biological Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Biological Engineering Bersini, S. Moretti, Matteo Jeon, Jessie S Kamm, Roger Dale |
| author_sort | Bersini, S. |
| collection | MIT |
| description | A crucial event in the metastatic cascade is the extravasation of circulating cancer cells from blood capillaries to the surrounding tissues. The past 5 years have been characterized by a significant evolution in the development of in vitro extravasation models, which moved from traditional transmigration chambers to more sophisticated microfluidic devices, enabling the study of complex cell–cell and cell–matrix interactions in multicellular, controlled environments. These advanced assays could be applied to screen easily and rapidly a broad spectrum of molecules inhibiting cancer cell endothelial adhesion and extravasation, thus contributing to the design of more focused in vivo tests. |
| first_indexed | 2024-09-23T14:46:15Z |
| format | Article |
| id | mit-1721.1/110374 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T14:46:15Z |
| publishDate | 2017 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/1103742022-10-01T22:20:25Z In vitro models of the metastatic cascade: from local invasion to extravasation Bersini, S. Moretti, Matteo Jeon, Jessie S Kamm, Roger Dale Massachusetts Institute of Technology. Department of Biological Engineering Massachusetts Institute of Technology. Department of Mechanical Engineering Jeon, Jessie S Kamm, Roger Dale A crucial event in the metastatic cascade is the extravasation of circulating cancer cells from blood capillaries to the surrounding tissues. The past 5 years have been characterized by a significant evolution in the development of in vitro extravasation models, which moved from traditional transmigration chambers to more sophisticated microfluidic devices, enabling the study of complex cell–cell and cell–matrix interactions in multicellular, controlled environments. These advanced assays could be applied to screen easily and rapidly a broad spectrum of molecules inhibiting cancer cell endothelial adhesion and extravasation, thus contributing to the design of more focused in vivo tests. National Cancer Institute (U.S.) (R33 CA174550-01) National Cancer Institute (U.S.) (R21 CA140096) Repligen Corporation (Repligen Fellowship in Cancer Research) Charles Stark Draper Laboratory (Draper Fellowship) 2017-06-29T17:46:33Z 2017-06-29T17:46:33Z 2014-06 Article http://purl.org/eprint/type/JournalArticle 1359-6446 http://hdl.handle.net/1721.1/110374 Bersini, S., J.S. Jeon, Matteo Moretti, and R.D. Kamm. “In Vitro Models of the Metastatic Cascade: From Local Invasion to Extravasation.” Drug Discovery Today 19, no. 6 (June 2014): 735–742. https://orcid.org/0000-0002-7232-304X en_US http://dx.doi.org/10.1016/j.drudis.2013.12.006 Drug Discovery Today Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier PMC |
| spellingShingle | Bersini, S. Moretti, Matteo Jeon, Jessie S Kamm, Roger Dale In vitro models of the metastatic cascade: from local invasion to extravasation |
| title | In vitro models of the metastatic cascade: from local invasion to extravasation |
| title_full | In vitro models of the metastatic cascade: from local invasion to extravasation |
| title_fullStr | In vitro models of the metastatic cascade: from local invasion to extravasation |
| title_full_unstemmed | In vitro models of the metastatic cascade: from local invasion to extravasation |
| title_short | In vitro models of the metastatic cascade: from local invasion to extravasation |
| title_sort | in vitro models of the metastatic cascade from local invasion to extravasation |
| url | http://hdl.handle.net/1721.1/110374 https://orcid.org/0000-0002-7232-304X |
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