Copper Hydride Catalyzed Hydroamination of Alkenes and Alkynes
Over the past few years, CuH-catalyzed hydroamination has been discovered and developed as a robust and conceptually novel approach for the synthesis of enantioenriched secondary and tertiary amines. The success in this area of research was made possible through the large body of precedent in copper...
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| Format: | Article |
| Language: | en_US |
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Wiley Blackwell
2017
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| Online Access: | http://hdl.handle.net/1721.1/110464 https://orcid.org/0000-0002-7896-1683 https://orcid.org/0000-0001-6414-0908 https://orcid.org/0000-0003-3875-4775 |
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| author | Pirnot, Michael T Wang, Yiming Buchwald, Stephen Leffler |
| author2 | Massachusetts Institute of Technology. Department of Chemistry |
| author_facet | Massachusetts Institute of Technology. Department of Chemistry Pirnot, Michael T Wang, Yiming Buchwald, Stephen Leffler |
| author_sort | Pirnot, Michael T |
| collection | MIT |
| description | Over the past few years, CuH-catalyzed hydroamination has been discovered and developed as a robust and conceptually novel approach for the synthesis of enantioenriched secondary and tertiary amines. The success in this area of research was made possible through the large body of precedent in copper(I) hydride catalysis and the well-explored use of hydroxylamine esters as electrophilic amine sources in related copper-catalyzed processes. This Minireview details the background, advances, and mechanistic investigations in CuH-catalyzed hydroamination. |
| first_indexed | 2024-09-23T09:00:48Z |
| format | Article |
| id | mit-1721.1/110464 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T09:00:48Z |
| publishDate | 2017 |
| publisher | Wiley Blackwell |
| record_format | dspace |
| spelling | mit-1721.1/1104642022-09-30T12:51:14Z Copper Hydride Catalyzed Hydroamination of Alkenes and Alkynes Pirnot, Michael T Wang, Yiming Buchwald, Stephen Leffler Massachusetts Institute of Technology. Department of Chemistry Pirnot, Michael T Wang, Yiming Buchwald, Stephen Leffler Over the past few years, CuH-catalyzed hydroamination has been discovered and developed as a robust and conceptually novel approach for the synthesis of enantioenriched secondary and tertiary amines. The success in this area of research was made possible through the large body of precedent in copper(I) hydride catalysis and the well-explored use of hydroxylamine esters as electrophilic amine sources in related copper-catalyzed processes. This Minireview details the background, advances, and mechanistic investigations in CuH-catalyzed hydroamination. National Institutes of Health (U.S.) (GM58160) National Institutes of Health (U.S.) (Postdoctoral Fellowship GM113311) National Institutes of Health (U.S.) (Postdoctoral Fellowship GM112218) 2017-07-05T16:24:32Z 2017-07-05T16:24:32Z 2015-12 2015-08 Article http://purl.org/eprint/type/JournalArticle 1433-7851 http://hdl.handle.net/1721.1/110464 Pirnot, Michael T., Yi-Ming Wang, and Stephen L. Buchwald. “Copper Hydride Catalyzed Hydroamination of Alkenes and Alkynes.” Angewandte Chemie International Edition 55.1 (2016): 48–57. https://orcid.org/0000-0002-7896-1683 https://orcid.org/0000-0001-6414-0908 https://orcid.org/0000-0003-3875-4775 en_US http://dx.doi.org/10.1002/anie.201507594 Angewandte Chemie International Edition Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Wiley Blackwell PMC |
| spellingShingle | Pirnot, Michael T Wang, Yiming Buchwald, Stephen Leffler Copper Hydride Catalyzed Hydroamination of Alkenes and Alkynes |
| title | Copper Hydride Catalyzed Hydroamination of Alkenes and Alkynes |
| title_full | Copper Hydride Catalyzed Hydroamination of Alkenes and Alkynes |
| title_fullStr | Copper Hydride Catalyzed Hydroamination of Alkenes and Alkynes |
| title_full_unstemmed | Copper Hydride Catalyzed Hydroamination of Alkenes and Alkynes |
| title_short | Copper Hydride Catalyzed Hydroamination of Alkenes and Alkynes |
| title_sort | copper hydride catalyzed hydroamination of alkenes and alkynes |
| url | http://hdl.handle.net/1721.1/110464 https://orcid.org/0000-0002-7896-1683 https://orcid.org/0000-0001-6414-0908 https://orcid.org/0000-0003-3875-4775 |
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