Highly Diastereo- and Enantioselective CuH-Catalyzed Synthesis of 2,3-Disubstituted Indolines
A diastereo- and enantioselective CuH-catalyzed method for the preparation of highly functionalized indolines is reported. The mild reaction conditions and high degree of functional group compatibility as demonstrated with substrates bearing heterocycles, olefins, and substituted aromatic groups, re...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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American Chemical Society (ACS)
2017
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| Online Access: | http://hdl.handle.net/1721.1/110473 https://orcid.org/0000-0003-3875-4775 |
| _version_ | 1811072868008591360 |
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| author | Ascic, Erhad Buchwald, Stephen Leffler |
| author2 | Massachusetts Institute of Technology. Department of Chemistry |
| author_facet | Massachusetts Institute of Technology. Department of Chemistry Ascic, Erhad Buchwald, Stephen Leffler |
| author_sort | Ascic, Erhad |
| collection | MIT |
| description | A diastereo- and enantioselective CuH-catalyzed method for the preparation of highly functionalized indolines is reported. The mild reaction conditions and high degree of functional group compatibility as demonstrated with substrates bearing heterocycles, olefins, and substituted aromatic groups, renders this technique highly valuable for the synthesis of a variety of cis-2,3-disubstituted indolines in high yield and enantioeselectivity. |
| first_indexed | 2024-09-23T09:18:10Z |
| format | Article |
| id | mit-1721.1/110473 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T09:18:10Z |
| publishDate | 2017 |
| publisher | American Chemical Society (ACS) |
| record_format | dspace |
| spelling | mit-1721.1/1104732022-09-26T11:15:06Z Highly Diastereo- and Enantioselective CuH-Catalyzed Synthesis of 2,3-Disubstituted Indolines Ascic, Erhad Buchwald, Stephen Leffler Massachusetts Institute of Technology. Department of Chemistry Ascic, Erhad Buchwald, Stephen Leffler A diastereo- and enantioselective CuH-catalyzed method for the preparation of highly functionalized indolines is reported. The mild reaction conditions and high degree of functional group compatibility as demonstrated with substrates bearing heterocycles, olefins, and substituted aromatic groups, renders this technique highly valuable for the synthesis of a variety of cis-2,3-disubstituted indolines in high yield and enantioeselectivity. National Institutes of Health (U.S.) (Award GM46059) Danish Council for Independent Research (Postdoctoral Fellowship) 2017-07-05T18:40:21Z 2017-07-05T18:40:21Z 2015-03 2015-03 Article http://purl.org/eprint/type/JournalArticle 0002-7863 1520-5126 http://hdl.handle.net/1721.1/110473 Ascic, Erhad, and Stephen L. Buchwald. “Highly Diastereo- and Enantioselective CuH-Catalyzed Synthesis of 2,3-Disubstituted Indolines.” Journal of the American Chemical Society 137.14 (2015): 4666–4669. © 2015 American Chemical Society https://orcid.org/0000-0003-3875-4775 en_US http://dx.doi.org/10.1021/jacs.5b02316 Journal of the American Chemical Society Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf American Chemical Society (ACS) ACS |
| spellingShingle | Ascic, Erhad Buchwald, Stephen Leffler Highly Diastereo- and Enantioselective CuH-Catalyzed Synthesis of 2,3-Disubstituted Indolines |
| title | Highly Diastereo- and Enantioselective CuH-Catalyzed Synthesis of 2,3-Disubstituted Indolines |
| title_full | Highly Diastereo- and Enantioselective CuH-Catalyzed Synthesis of 2,3-Disubstituted Indolines |
| title_fullStr | Highly Diastereo- and Enantioselective CuH-Catalyzed Synthesis of 2,3-Disubstituted Indolines |
| title_full_unstemmed | Highly Diastereo- and Enantioselective CuH-Catalyzed Synthesis of 2,3-Disubstituted Indolines |
| title_short | Highly Diastereo- and Enantioselective CuH-Catalyzed Synthesis of 2,3-Disubstituted Indolines |
| title_sort | highly diastereo and enantioselective cuh catalyzed synthesis of 2 3 disubstituted indolines |
| url | http://hdl.handle.net/1721.1/110473 https://orcid.org/0000-0003-3875-4775 |
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