Broken Detailed Balance of Filament Dynamics in Active Networks
Myosin motor proteins drive vigorous steady-state fluctuations in the actin cytoskeleton of cells. Endogenous embedded semiflexible filaments such as microtubules, or added filaments such as single-walled carbon nanotubes are used as novel tools to noninvasively track equilibrium and nonequilibrium...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
American Physical Society
2017
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| Online Access: | http://hdl.handle.net/1721.1/110491 https://orcid.org/0000-0003-1261-7465 |
| _version_ | 1826191005491134464 |
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| author | Gladrow, J. MacKintosh, F. C. Schmidt, C. F. Broedersz, C. P. Fakhri, Nikta |
| author2 | Massachusetts Institute of Technology. Department of Physics |
| author_facet | Massachusetts Institute of Technology. Department of Physics Gladrow, J. MacKintosh, F. C. Schmidt, C. F. Broedersz, C. P. Fakhri, Nikta |
| author_sort | Gladrow, J. |
| collection | MIT |
| description | Myosin motor proteins drive vigorous steady-state fluctuations in the actin cytoskeleton of cells. Endogenous embedded semiflexible filaments such as microtubules, or added filaments such as single-walled carbon nanotubes are used as novel tools to noninvasively track equilibrium and nonequilibrium fluctuations in such biopolymer networks. Here, we analytically calculate shape fluctuations of semiflexible probe filaments in a viscoelastic environment, driven out of equilibrium by motor activity. Transverse bending fluctuations of the probe filaments can be decomposed into dynamic normal modes. We find that these modes no longer evolve independently under nonequilibrium driving. This effective mode coupling results in nonzero circulatory currents in a conformational phase space, reflecting a violation of detailed balance. We present predictions for the characteristic frequencies associated with these currents and investigate how the temporal signatures of motor activity determine mode correlations, which we find to be consistent with recent experiments on microtubules embedded in cytoskeletal networks. |
| first_indexed | 2024-09-23T08:48:39Z |
| format | Article |
| id | mit-1721.1/110491 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T08:48:39Z |
| publishDate | 2017 |
| publisher | American Physical Society |
| record_format | dspace |
| spelling | mit-1721.1/1104912022-09-30T11:27:10Z Broken Detailed Balance of Filament Dynamics in Active Networks Gladrow, J. MacKintosh, F. C. Schmidt, C. F. Broedersz, C. P. Fakhri, Nikta Massachusetts Institute of Technology. Department of Physics Fakhri, Nikta Myosin motor proteins drive vigorous steady-state fluctuations in the actin cytoskeleton of cells. Endogenous embedded semiflexible filaments such as microtubules, or added filaments such as single-walled carbon nanotubes are used as novel tools to noninvasively track equilibrium and nonequilibrium fluctuations in such biopolymer networks. Here, we analytically calculate shape fluctuations of semiflexible probe filaments in a viscoelastic environment, driven out of equilibrium by motor activity. Transverse bending fluctuations of the probe filaments can be decomposed into dynamic normal modes. We find that these modes no longer evolve independently under nonequilibrium driving. This effective mode coupling results in nonzero circulatory currents in a conformational phase space, reflecting a violation of detailed balance. We present predictions for the characteristic frequencies associated with these currents and investigate how the temporal signatures of motor activity determine mode correlations, which we find to be consistent with recent experiments on microtubules embedded in cytoskeletal networks. National Science Foundation (U.S.) (PHY11-25915) 2017-07-06T15:40:32Z 2017-07-06T15:40:32Z 2016-06 2016-05 2016-06-17T22:00:07Z Article http://purl.org/eprint/type/JournalArticle 0031-9007 1079-7114 http://hdl.handle.net/1721.1/110491 Gladrow, J.; Fakhri, N.; MacKintosh, F. C.; Schmidt, C. F. and Broedersz, C. P. "Broken Detailed Balance of Filament Dynamics in Active Networks." Physical Review Letters 116, 248301 (June 2016): 1-6 © 2016 American Physical Society https://orcid.org/0000-0003-1261-7465 en http://dx.doi.org/10.1103/PhysRevLett.116.248301 Physical Review Letters Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. American Physical Society application/pdf American Physical Society American Physical Society |
| spellingShingle | Gladrow, J. MacKintosh, F. C. Schmidt, C. F. Broedersz, C. P. Fakhri, Nikta Broken Detailed Balance of Filament Dynamics in Active Networks |
| title | Broken Detailed Balance of Filament Dynamics in Active Networks |
| title_full | Broken Detailed Balance of Filament Dynamics in Active Networks |
| title_fullStr | Broken Detailed Balance of Filament Dynamics in Active Networks |
| title_full_unstemmed | Broken Detailed Balance of Filament Dynamics in Active Networks |
| title_short | Broken Detailed Balance of Filament Dynamics in Active Networks |
| title_sort | broken detailed balance of filament dynamics in active networks |
| url | http://hdl.handle.net/1721.1/110491 https://orcid.org/0000-0003-1261-7465 |
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