FRET-enabled biological characterization of polymeric micelles
Translation of micelles from the laboratory to the clinic is limited by a poor understanding of their in vivo fate following administration. In this paper, we establish a robust approach to real-time monitoring of the in vivo stability of micelles using Förster Resonance Energy Transfer (FRET). This...
| المؤلفون الرئيسيون: | , , , |
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| مؤلفون آخرون: | |
| التنسيق: | مقال |
| اللغة: | en_US |
| منشور في: |
Elsevier
2017
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| الوصول للمادة أونلاين: | http://hdl.handle.net/1721.1/110543 https://orcid.org/0000-0002-5568-6455 |
| _version_ | 1826191882255859712 |
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| author | Morton, Stephen Winford Zhao, Xiaoyong Quadir, Mohiuddin Abdul Hammond, Paula T |
| author2 | Massachusetts Institute of Technology. Institute for Soldier Nanotechnologies |
| author_facet | Massachusetts Institute of Technology. Institute for Soldier Nanotechnologies Morton, Stephen Winford Zhao, Xiaoyong Quadir, Mohiuddin Abdul Hammond, Paula T |
| author_sort | Morton, Stephen Winford |
| collection | MIT |
| description | Translation of micelles from the laboratory to the clinic is limited by a poor understanding of their in vivo fate following administration. In this paper, we establish a robust approach to real-time monitoring of the in vivo stability of micelles using Förster Resonance Energy Transfer (FRET). This characterization method allows for exquisite insight into the fate of micellar constituents, affording the capabilities to rapidly and efficiently evaluate a library of synthetically derived micellar systems as new therapeutic platforms in vivo. FRET-enabled biological characterization further holds potential to tailor material systems being uniquely investigated across the delivery community towards the next generation of stable therapeutics for disease management. |
| first_indexed | 2024-09-23T09:02:45Z |
| format | Article |
| id | mit-1721.1/110543 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T09:02:45Z |
| publishDate | 2017 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/1105432022-09-26T10:03:50Z FRET-enabled biological characterization of polymeric micelles Morton, Stephen Winford Zhao, Xiaoyong Quadir, Mohiuddin Abdul Hammond, Paula T Massachusetts Institute of Technology. Institute for Soldier Nanotechnologies Massachusetts Institute of Technology. Department of Chemical Engineering Koch Institute for Integrative Cancer Research at MIT Morton, Stephen Winford Zhao, Xiaoyong Quadir, Mohiuddin Abdul Hammond, Paula T Translation of micelles from the laboratory to the clinic is limited by a poor understanding of their in vivo fate following administration. In this paper, we establish a robust approach to real-time monitoring of the in vivo stability of micelles using Förster Resonance Energy Transfer (FRET). This characterization method allows for exquisite insight into the fate of micellar constituents, affording the capabilities to rapidly and efficiently evaluate a library of synthetically derived micellar systems as new therapeutic platforms in vivo. FRET-enabled biological characterization further holds potential to tailor material systems being uniquely investigated across the delivery community towards the next generation of stable therapeutics for disease management. National Cancer Institute (U.S.) (P30-CA14051) National Institutes of Health (U.S.) (5 U54 CA151884-02) 2017-07-07T17:43:14Z 2017-07-07T17:43:14Z 2014-01 2013-11 Article http://purl.org/eprint/type/JournalArticle 0142-9612 1878-5905 http://hdl.handle.net/1721.1/110543 Morton, Stephen W.; Zhao, Xiaoyong; Quadir, Mohiuddin A. and Hammond, Paula T. “FRET-Enabled Biological Characterization of Polymeric Micelles.” Biomaterials 35, 11 (April 2014): 3489–3496 © 2014 Elsevier Ltd https://orcid.org/0000-0002-5568-6455 en_US http://dx.doi.org/10.1016/j.biomaterials.2014.01.027 Biomaterials Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier PMC |
| spellingShingle | Morton, Stephen Winford Zhao, Xiaoyong Quadir, Mohiuddin Abdul Hammond, Paula T FRET-enabled biological characterization of polymeric micelles |
| title | FRET-enabled biological characterization of polymeric micelles |
| title_full | FRET-enabled biological characterization of polymeric micelles |
| title_fullStr | FRET-enabled biological characterization of polymeric micelles |
| title_full_unstemmed | FRET-enabled biological characterization of polymeric micelles |
| title_short | FRET-enabled biological characterization of polymeric micelles |
| title_sort | fret enabled biological characterization of polymeric micelles |
| url | http://hdl.handle.net/1721.1/110543 https://orcid.org/0000-0002-5568-6455 |
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