Limited value of pro-inflammatory oxylipins and cytokines as circulating biomarkers in endometriosis--a targeted ‘omics study
Endometriosis is a common, complex gynecologic disorder characterized by the presence of endometrial-like tissues at extrauterine sites. Elevation in protein and lipid mediators of inflammation including oxylipins and cytokines within the peritoneum characterize the inflamed pelvic region and may co...
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| Format: | Article |
| Language: | en_US |
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Springer Nature
2017
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| Online Access: | http://hdl.handle.net/1721.1/110851 |
| _version_ | 1826197323640733696 |
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| author | Lee, Yie Hou Cui, Liang Fang, Jinling Chern, Bernard Su Min Tan, Heng Hao Chan, Jerry K. Y. |
| author2 | Massachusetts Institute of Technology. Department of Biological Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Biological Engineering Lee, Yie Hou Cui, Liang Fang, Jinling Chern, Bernard Su Min Tan, Heng Hao Chan, Jerry K. Y. |
| author_sort | Lee, Yie Hou |
| collection | MIT |
| description | Endometriosis is a common, complex gynecologic disorder characterized by the presence of endometrial-like tissues at extrauterine sites. Elevation in protein and lipid mediators of inflammation including oxylipins and cytokines within the peritoneum characterize the inflamed pelvic region and may contribute to the survival and growth of displaced endometrial tissues. The presence of a clinically silent but molecularly detectable systemic inflammation in endometriosis has been proposed. Thus, we examined serum oxylipin and immunomodulatory protein levels in 103 women undergoing laparoscopy to evaluate systematically any involvement in systemic pathophysiological inflammation in endometriosis. Oxylipin levels were similar between women with and without endometriosis. Stratification by menstrual phase or severity did not offer any difference. Women with ovarian endometriosis had significantly lower 12-HETE relative to peritoneal endometriosis (−50.7%). Serum oxylipin levels were not associated with pre-operative pain symptoms. Changes to immunomodulatory proteins were minimal, with IL-12(p70), IL-13 and VEGF significantly lower in mild endometriotic women compared to non-endometriotic women (−39%, −54% and −76% respectively). Verification using C-reactive protein as a non-specific marker of inflammation further showed similar levels between groups. The implications of our work suggest pro-inflammatory mediators in the classes studied may have potentially limited value as circulating biomarkers for endometriosis, suggesting of potentially tenuous systemic inflammation in endometriosis. |
| first_indexed | 2024-09-23T10:45:55Z |
| format | Article |
| id | mit-1721.1/110851 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T10:45:55Z |
| publishDate | 2017 |
| publisher | Springer Nature |
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| spelling | mit-1721.1/1108512022-09-27T14:48:46Z Limited value of pro-inflammatory oxylipins and cytokines as circulating biomarkers in endometriosis--a targeted ‘omics study Lee, Yie Hou Cui, Liang Fang, Jinling Chern, Bernard Su Min Tan, Heng Hao Chan, Jerry K. Y. Massachusetts Institute of Technology. Department of Biological Engineering Lee, Yie Hou Cui, Liang Endometriosis is a common, complex gynecologic disorder characterized by the presence of endometrial-like tissues at extrauterine sites. Elevation in protein and lipid mediators of inflammation including oxylipins and cytokines within the peritoneum characterize the inflamed pelvic region and may contribute to the survival and growth of displaced endometrial tissues. The presence of a clinically silent but molecularly detectable systemic inflammation in endometriosis has been proposed. Thus, we examined serum oxylipin and immunomodulatory protein levels in 103 women undergoing laparoscopy to evaluate systematically any involvement in systemic pathophysiological inflammation in endometriosis. Oxylipin levels were similar between women with and without endometriosis. Stratification by menstrual phase or severity did not offer any difference. Women with ovarian endometriosis had significantly lower 12-HETE relative to peritoneal endometriosis (−50.7%). Serum oxylipin levels were not associated with pre-operative pain symptoms. Changes to immunomodulatory proteins were minimal, with IL-12(p70), IL-13 and VEGF significantly lower in mild endometriotic women compared to non-endometriotic women (−39%, −54% and −76% respectively). Verification using C-reactive protein as a non-specific marker of inflammation further showed similar levels between groups. The implications of our work suggest pro-inflammatory mediators in the classes studied may have potentially limited value as circulating biomarkers for endometriosis, suggesting of potentially tenuous systemic inflammation in endometriosis. Singapore. National Medical Research Council (NMRC/BNIG/2033/2015) SingHealth Foundation (SHF/FG560P/2014) 2017-07-26T14:56:48Z 2017-07-26T14:56:48Z 2016-05 2016-02 Article http://purl.org/eprint/type/JournalArticle 2045-2322 http://hdl.handle.net/1721.1/110851 Lee, Yie Hou, Liang Cui, Jinling Fang, Bernard Su Min Chern, Heng Hao Tan, and Jerry K. Y. Chan. "Limited value of pro-inflammatory oxylipins and cytokines as circulating biomarkers in endometriosis--a targeted ‘omics study." Scientific Reports 6, Article number: 26117 (2016), pp.1-7. en_US http://dx.doi.org/10.1038/srep26117 Scientific Reports Creative Commons Attribution 4.0 International License http://creativecommons.org/licenses/by/4.0/ application/pdf Springer Nature Scientific Reports |
| spellingShingle | Lee, Yie Hou Cui, Liang Fang, Jinling Chern, Bernard Su Min Tan, Heng Hao Chan, Jerry K. Y. Limited value of pro-inflammatory oxylipins and cytokines as circulating biomarkers in endometriosis--a targeted ‘omics study |
| title | Limited value of pro-inflammatory oxylipins and cytokines as circulating biomarkers in endometriosis--a targeted ‘omics study |
| title_full | Limited value of pro-inflammatory oxylipins and cytokines as circulating biomarkers in endometriosis--a targeted ‘omics study |
| title_fullStr | Limited value of pro-inflammatory oxylipins and cytokines as circulating biomarkers in endometriosis--a targeted ‘omics study |
| title_full_unstemmed | Limited value of pro-inflammatory oxylipins and cytokines as circulating biomarkers in endometriosis--a targeted ‘omics study |
| title_short | Limited value of pro-inflammatory oxylipins and cytokines as circulating biomarkers in endometriosis--a targeted ‘omics study |
| title_sort | limited value of pro inflammatory oxylipins and cytokines as circulating biomarkers in endometriosis a targeted omics study |
| url | http://hdl.handle.net/1721.1/110851 |
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