Three-Dimensional Enhanced Imaging of Vitreoretinal Interface in Diabetic Retinopathy Using Swept-Source Optical Coherence Tomography
Purpose To analyze the vitreoretinal interface in diabetic eyes using 3-dimensional wide-field volumes acquired using high-speed, long-wavelength swept-source optical coherence tomography (SSOCT). Design Prospective cross-sectional study. Methods Fifty-six diabetic patients (88 eyes) and...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | en_US |
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Elsevier
2017
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| Online Access: | http://hdl.handle.net/1721.1/110908 https://orcid.org/0000-0002-0828-4357 |
| _version_ | 1811096848653352960 |
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| author | Badaro, Emmerson Kraus, Martin F. Baumal, Caroline R. Witkin, Andre J. Hornegger, Joachim Duker, Jay S. Waheed, Nadia K. Adhi, Mehreen Liu, Jonathan Jaoshin Fujimoto, James G |
| author2 | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science |
| author_facet | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Badaro, Emmerson Kraus, Martin F. Baumal, Caroline R. Witkin, Andre J. Hornegger, Joachim Duker, Jay S. Waheed, Nadia K. Adhi, Mehreen Liu, Jonathan Jaoshin Fujimoto, James G |
| author_sort | Badaro, Emmerson |
| collection | MIT |
| description | Purpose
To analyze the vitreoretinal interface in diabetic eyes using 3-dimensional wide-field volumes acquired using high-speed, long-wavelength swept-source optical coherence tomography (SSOCT).
Design
Prospective cross-sectional study.
Methods
Fifty-six diabetic patients (88 eyes) and 11 healthy nondiabetic controls (22 eyes) were recruited. Up to 8 SSOCT volumes were acquired for each eye. A registration algorithm removed motion artifacts and merged multiple SSOCT volumes to improve signal. Vitreous visualization was enhanced using vitreous windowing method.
Results
Of 88 diabetic eyes, 20 eyes had no retinopathy, 21 eyes had nonproliferative diabetic retinopathy (NPDR) without macular edema, 20 eyes had proliferative diabetic retinopathy (PDR) without macular edema, and 27 eyes had diabetic macular edema (DME) with either NPDR or PDR. Thick posterior hyaloid relative to healthy nondiabetic controls was observed in 0 of 20 (0%) diabetic eyes without retinopathy, 4 of 21 (19%) eyes with NPDR, 11 of 20 (55%) eyes with PDR, and 11 of 27 (41%) eyes with DME (P = .0001). Vitreoschisis was observed in 6 of 22 (27%) healthy nondiabetic eyes, 9 of 20 (45%) diabetic eyes without retinopathy, 10 of 21 (48%) eyes with NPDR, 13 of 20 (65%) eyes with PDR, and 17 of 27 (63%) eyes with DME (P = .007). While no healthy nondiabetic controls and diabetic eyes without retinopathy had adhesions/pegs between detached posterior hyaloid and retina, 1 of 21 (4%), 11 of 20 (55%), and 11 of 27 (41%) eyes with NPDR, PDR, and DME, respectively, demonstrated this feature (P = .0001).
Conclusion
SSOCT with motion-correction and vitreous windowing provides wide-field 3-dimensional information of vitreoretinal interface in diabetic eyes. This may be useful in assessing progression of retinopathy, planning diabetic vitreous surgery, and predicting treatment outcomes. |
| first_indexed | 2024-09-23T16:49:58Z |
| format | Article |
| id | mit-1721.1/110908 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T16:49:58Z |
| publishDate | 2017 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/1109082022-10-03T08:37:50Z Three-Dimensional Enhanced Imaging of Vitreoretinal Interface in Diabetic Retinopathy Using Swept-Source Optical Coherence Tomography Badaro, Emmerson Kraus, Martin F. Baumal, Caroline R. Witkin, Andre J. Hornegger, Joachim Duker, Jay S. Waheed, Nadia K. Adhi, Mehreen Liu, Jonathan Jaoshin Fujimoto, James G Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology. Research Laboratory of Electronics Adhi, Mehreen Liu, Jonathan Jaoshin Fujimoto, James G Purpose To analyze the vitreoretinal interface in diabetic eyes using 3-dimensional wide-field volumes acquired using high-speed, long-wavelength swept-source optical coherence tomography (SSOCT). Design Prospective cross-sectional study. Methods Fifty-six diabetic patients (88 eyes) and 11 healthy nondiabetic controls (22 eyes) were recruited. Up to 8 SSOCT volumes were acquired for each eye. A registration algorithm removed motion artifacts and merged multiple SSOCT volumes to improve signal. Vitreous visualization was enhanced using vitreous windowing method. Results Of 88 diabetic eyes, 20 eyes had no retinopathy, 21 eyes had nonproliferative diabetic retinopathy (NPDR) without macular edema, 20 eyes had proliferative diabetic retinopathy (PDR) without macular edema, and 27 eyes had diabetic macular edema (DME) with either NPDR or PDR. Thick posterior hyaloid relative to healthy nondiabetic controls was observed in 0 of 20 (0%) diabetic eyes without retinopathy, 4 of 21 (19%) eyes with NPDR, 11 of 20 (55%) eyes with PDR, and 11 of 27 (41%) eyes with DME (P = .0001). Vitreoschisis was observed in 6 of 22 (27%) healthy nondiabetic eyes, 9 of 20 (45%) diabetic eyes without retinopathy, 10 of 21 (48%) eyes with NPDR, 13 of 20 (65%) eyes with PDR, and 17 of 27 (63%) eyes with DME (P = .007). While no healthy nondiabetic controls and diabetic eyes without retinopathy had adhesions/pegs between detached posterior hyaloid and retina, 1 of 21 (4%), 11 of 20 (55%), and 11 of 27 (41%) eyes with NPDR, PDR, and DME, respectively, demonstrated this feature (P = .0001). Conclusion SSOCT with motion-correction and vitreous windowing provides wide-field 3-dimensional information of vitreoretinal interface in diabetic eyes. This may be useful in assessing progression of retinopathy, planning diabetic vitreous surgery, and predicting treatment outcomes. National Institutes of Health (U.S.) (R01-EY011289-28) National Institutes of Health (U.S.) (R01-EY013178-12) National Institutes of Health (U.S.) (R01-CA075289-16) United States. Air Force Office of Scientific Research (FA9550-10-1-0551) United States. Air Force Office of Scientific Research (FA9550-12-1-0499) 2017-08-02T15:21:59Z 2017-08-02T15:21:59Z 2015-11 2015-10 Article http://purl.org/eprint/type/JournalArticle 0002-9394 http://hdl.handle.net/1721.1/110908 Adhi, Mehreen; Badaro, Emmerson; Liu, Jonathan J. et al. “Three-Dimensional Enhanced Imaging of Vitreoretinal Interface in Diabetic Retinopathy Using Swept-Source Optical Coherence Tomography.” American Journal of Ophthalmology 162 (February 2016): 140–149 © 2016 Elsevier Inc https://orcid.org/0000-0002-0828-4357 en_US http://dx.doi.org/10.1016/j.ajo.2015.10.025 American Journal of Ophthalmology Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier PMC |
| spellingShingle | Badaro, Emmerson Kraus, Martin F. Baumal, Caroline R. Witkin, Andre J. Hornegger, Joachim Duker, Jay S. Waheed, Nadia K. Adhi, Mehreen Liu, Jonathan Jaoshin Fujimoto, James G Three-Dimensional Enhanced Imaging of Vitreoretinal Interface in Diabetic Retinopathy Using Swept-Source Optical Coherence Tomography |
| title | Three-Dimensional Enhanced Imaging of Vitreoretinal Interface in Diabetic Retinopathy Using Swept-Source Optical Coherence Tomography |
| title_full | Three-Dimensional Enhanced Imaging of Vitreoretinal Interface in Diabetic Retinopathy Using Swept-Source Optical Coherence Tomography |
| title_fullStr | Three-Dimensional Enhanced Imaging of Vitreoretinal Interface in Diabetic Retinopathy Using Swept-Source Optical Coherence Tomography |
| title_full_unstemmed | Three-Dimensional Enhanced Imaging of Vitreoretinal Interface in Diabetic Retinopathy Using Swept-Source Optical Coherence Tomography |
| title_short | Three-Dimensional Enhanced Imaging of Vitreoretinal Interface in Diabetic Retinopathy Using Swept-Source Optical Coherence Tomography |
| title_sort | three dimensional enhanced imaging of vitreoretinal interface in diabetic retinopathy using swept source optical coherence tomography |
| url | http://hdl.handle.net/1721.1/110908 https://orcid.org/0000-0002-0828-4357 |
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