Three-dimensional morphological response of lipid-rich coronary plaques to statin therapy
Objective: Previous studies have suggested that intensive statin therapy, compared with moderate statin therapy, provided greater reduction of LDL and better protection against major cardiovascular events. However, the exact dose-dependent mechanism of plaque stabilization remains unclear. The aim o...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | en_US |
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Lippincott Williams & Wilkins
2017
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| Online Access: | http://hdl.handle.net/1721.1/110913 https://orcid.org/0000-0002-9724-5164 |
| _version_ | 1811072738455977984 |
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| author | Wang, Zhao Cho, Young-Seok Soeda, Tsunenari Minami, Yoshiyasu Xing, Lei Jia, Haibo Aguirre, Aaron Vergallo, Rocco Lee, Hang Fujimoto, James G. Yu, Bo Jang, Ik-Kyung |
| author2 | Massachusetts Institute of Technology. Research Laboratory of Electronics |
| author_facet | Massachusetts Institute of Technology. Research Laboratory of Electronics Wang, Zhao Cho, Young-Seok Soeda, Tsunenari Minami, Yoshiyasu Xing, Lei Jia, Haibo Aguirre, Aaron Vergallo, Rocco Lee, Hang Fujimoto, James G. Yu, Bo Jang, Ik-Kyung |
| author_sort | Wang, Zhao |
| collection | MIT |
| description | Objective: Previous studies have suggested that intensive statin therapy, compared with moderate statin therapy, provided greater reduction of LDL and better protection against major cardiovascular events. However, the exact dose-dependent mechanism of plaque stabilization remains unclear. The aim of this study is to investigate the three-dimensional (3D) response of fibrous caps overlying lipid plaques to statin therapy.
Methods: We applied a novel computer algorithm to investigate the fibrous cap 3D morphological change over time in patients with coronary artery disease. Patients were treated with either atorvastatin 20 mg/day (moderate intensity) or atorvastatin 60 mg/day (high intensity). Optical coherence tomography was performed at baseline, 6, and 12 months. A total of 31 lipid plaques from 21 patients were analyzed.
Results: Conventional metrics such as the minimum fibrous cap thickness change between the two treatment groups were not significantly different between the baseline and the 12-month follow-up. In contrast, the 3D metric thin cap (<80 [mu]m) surface area change between the baseline and the 12-month follow-up showed dose-dependent, significant differences between the statin treatment groups (P<0.001). 3D reconstructions of fibrous caps further indicated that fibrous caps showed diverse (scattered vs. confluent) patterns and could evolve in a complex manner.
Conclusion: High-intensity statin therapy more effectively stabilized fibrous caps at follow-up. The new 3D algorithm provided more comprehensive and detailed information on the changes in plaque phenotype in response to statin therapy. |
| first_indexed | 2024-09-23T09:11:30Z |
| format | Article |
| id | mit-1721.1/110913 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T09:11:30Z |
| publishDate | 2017 |
| publisher | Lippincott Williams & Wilkins |
| record_format | dspace |
| spelling | mit-1721.1/1109132022-09-30T14:01:41Z Three-dimensional morphological response of lipid-rich coronary plaques to statin therapy Wang, Zhao Cho, Young-Seok Soeda, Tsunenari Minami, Yoshiyasu Xing, Lei Jia, Haibo Aguirre, Aaron Vergallo, Rocco Lee, Hang Fujimoto, James G. Yu, Bo Jang, Ik-Kyung Massachusetts Institute of Technology. Research Laboratory of Electronics Wang, Zhao Objective: Previous studies have suggested that intensive statin therapy, compared with moderate statin therapy, provided greater reduction of LDL and better protection against major cardiovascular events. However, the exact dose-dependent mechanism of plaque stabilization remains unclear. The aim of this study is to investigate the three-dimensional (3D) response of fibrous caps overlying lipid plaques to statin therapy. Methods: We applied a novel computer algorithm to investigate the fibrous cap 3D morphological change over time in patients with coronary artery disease. Patients were treated with either atorvastatin 20 mg/day (moderate intensity) or atorvastatin 60 mg/day (high intensity). Optical coherence tomography was performed at baseline, 6, and 12 months. A total of 31 lipid plaques from 21 patients were analyzed. Results: Conventional metrics such as the minimum fibrous cap thickness change between the two treatment groups were not significantly different between the baseline and the 12-month follow-up. In contrast, the 3D metric thin cap (<80 [mu]m) surface area change between the baseline and the 12-month follow-up showed dose-dependent, significant differences between the statin treatment groups (P<0.001). 3D reconstructions of fibrous caps further indicated that fibrous caps showed diverse (scattered vs. confluent) patterns and could evolve in a complex manner. Conclusion: High-intensity statin therapy more effectively stabilized fibrous caps at follow-up. The new 3D algorithm provided more comprehensive and detailed information on the changes in plaque phenotype in response to statin therapy. 2017-08-03T13:45:14Z 2017-08-03T13:45:14Z 2016-08 Article http://purl.org/eprint/type/JournalArticle 0954-6928 http://hdl.handle.net/1721.1/110913 Wang, Zhao; Cho, Young-Seok; Soeda, Tsunenari et al. “Three-Dimensional Morphological Response of Lipid-Rich Coronary Plaques to Statin Therapy.” Coronary Artery Disease 27, 5 (August 2016): 350–356 © 2016 Wolters Kluwer Health, Inc https://orcid.org/0000-0002-9724-5164 en_US http://dx.doi.org/10.1097/mca.0000000000000370 Coronary Artery Disease Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Lippincott Williams & Wilkins PMC |
| spellingShingle | Wang, Zhao Cho, Young-Seok Soeda, Tsunenari Minami, Yoshiyasu Xing, Lei Jia, Haibo Aguirre, Aaron Vergallo, Rocco Lee, Hang Fujimoto, James G. Yu, Bo Jang, Ik-Kyung Three-dimensional morphological response of lipid-rich coronary plaques to statin therapy |
| title | Three-dimensional morphological response of lipid-rich coronary plaques to statin therapy |
| title_full | Three-dimensional morphological response of lipid-rich coronary plaques to statin therapy |
| title_fullStr | Three-dimensional morphological response of lipid-rich coronary plaques to statin therapy |
| title_full_unstemmed | Three-dimensional morphological response of lipid-rich coronary plaques to statin therapy |
| title_short | Three-dimensional morphological response of lipid-rich coronary plaques to statin therapy |
| title_sort | three dimensional morphological response of lipid rich coronary plaques to statin therapy |
| url | http://hdl.handle.net/1721.1/110913 https://orcid.org/0000-0002-9724-5164 |
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