Optimization of Radiation Therapy Fractionation Schedules in the Presence of Tumor Repopulation

Optimization of Radiation Therapy Fractionation Schedules in the Presence of Tumor Repopulation

We analyze the effect of tumor repopulation on optimal dose delivery in radiation therapy. We are primarily motivated by accelerated tumor repopulation toward the end of radiation treatment, which is believed to play a role in treatment failure for some tumor sites. A dynamic programming framework i...

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Bibliographic Details
Main Authors: Bortfeld, Thomas, Ramakrishnan, Jagdish, Unkelbach, Jan, Tsitsiklis, John N
Other Authors: Massachusetts Institute of Technology. Laboratory for Information and Decision Systems
Format: Article
Language:en_US
Published: Institute for Operations Research and the Management Sciences (INFORMS) 2017
Online Access:http://hdl.handle.net/1721.1/111066
https://orcid.org/0000-0003-2658-8239

Internet

http://hdl.handle.net/1721.1/111066
https://orcid.org/0000-0003-2658-8239

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