Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes

Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes

Neuronal activity causes the rapid expression of immediate early genes that are crucial for experience-driven changes to synapses, learning, and memory. Here, using both molecular and genome-wide next-generation sequencing methods, we report that neuronal activity stimulation triggers the formation...

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Bibliographic Details
Main Authors: Madabhushi, Ram, Pfenning, Andreas R., Gao, Fan, Pan, Ling, Yamakawa, Satoko, Seo, Jinsoo, Rueda IV, Richard, Phan, Trongha, Yamakawa, Hidekuni, Pao, Ping-Chieh, Stott, Ryan T, Gjoneska, Elizabeta, Nott, Alexander, Cho, Sukhee, Kellis, Manolis, Tsai, Li-Huei
Other Authors: Broad Institute of MIT and Harvard
Format: Article
Language:en_US
Published: Elsevier 2017
Online Access:http://hdl.handle.net/1721.1/111076
https://orcid.org/0000-0002-3447-9801
https://orcid.org/0000-0001-9947-9071
https://orcid.org/0000-0003-3812-7851
https://orcid.org/0000-0001-6788-7185
https://orcid.org/0000-0003-3870-7725
https://orcid.org/0000-0002-3255-4740
https://orcid.org/0000-0002-2029-7193
https://orcid.org/0000-0003-1262-0592

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