In vivo shRNA screen reveals PRMT5 as a key regulator in glioblastoma

In vivo shRNA screen reveals PRMT5 as a key regulator in glioblastoma

Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biology, 2017.

Bibliographic Details
Main Author:	Stanciu, Monica
Other Authors:	Jacqueline Lees.
Format:	Thesis
Language:	eng
Published:	Massachusetts Institute of Technology 2017
Subjects:	Biology.
Online Access:	http://hdl.handle.net/1721.1/111285

Similar Items

In vivo pool-based shRNA screens to identify modulators of disease progression in hematopoietic malignancies
by: Meacham, Corbin Elizabeth
Published: (2012)

Engineering Periodic shRNA for Enhanced Silencing Efficacy
by: Wu, Connie, et al.
Published: (2021)

Pathway-based network modeling finds hidden genes in shRNA screen for regulators of acute lymphoblastic leukemia
by: Wilson, Jennifer Lynn, et al.
Published: (2017)

Optimization of Duplex Stability and Terminal Asymmetry for shRNA Design
by: Spiridonov, Alexey Nikolaevich, et al.
Published: (2010)

Efficient shRNA-Mediated Inhibition of Gene Expression in Zebrafish
by: Sive, Hazel L., et al.
Published: (2012)

Generation of lentiviral-mediated shRNA vectors to inhibit the expression of caspase-1 and Pycard/ASC in dendritic cells.
by: Tan, Bee Kim.
Published: (2010)

Identification of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as a novel autophagy regulator by high content shRNA screening
by: Strohecker, A M, et al.
Published: (2017)

Periodic-shRNA molecules are capable of gene silencing, cytotoxicity and innate immune activation in cancer cells
by: Wu, Connie, et al.
Published: (2016)

Co-delivery of TGF-β3 and COL I-targeting shRNA with adenoviral and lentiviral vectors for COL I-surpressed in vitro chondrogenesis
by: M. K. Mohamed Idris
Published: (2011)

Construction of recombinant adenovirus encoding both TGF-beta 3 and ShRNA targeting type I collagen gene.
by: Liu, Chengzheng.
Published: (2009)

Model studies aimed toward constructing PI3K pathways in leukemia T-cells from shRNA knockdowns
by: Sweeney, Heather M
Published: (2018)

Mechanisms and consequences of resistance to PRMT5 Inhibition
by: Mueller, Helen S.
Published: (2022)

PRMT5 Inhibitors in Merkel Cell Carcinoma
by: Higgins, Kathleen Whitmore
Published: (2024)

Co-transduction of lentiviral and adenoviral vectors for co-delivery of growth factor and shRNA genes in mesenchymal stem cells-based chondrogenic system
by: Zhang, Feng, et al.
Published: (2013)

Myc targeted CDK18 promotes ATR and homologous recombination to mediate PARP inhibitor resistance in glioblastoma
by: Stanciu, Monica, et al.
Published: (2020)

AAV-mediated direct in vivo CRISPR screen identifies functional suppressors in glioblastoma
by: Chow, Ryan D, et al.
Published: (2018)

Acquired resistance to PRMT5 inhibition induces concomitant collateral sensitivity to paclitaxel
by: Mueller, Helen S, et al.
Published: (2022)

Functional characterization of human respiratory syncytial virus (hRSV) small hydrophobic protein (SH) through small interfering RNA (siRNA) that targets SH.
by: Ngan, Grace Jie Yin.
Published: (2009)

In Vivo RNAi Screening Identifies Regulators of Actin Dynamics as Key Determinants of Lymphoma Progression
by: Ho, Emily E., et al.
Published: (2012)

Mechanism of acquired temozolomide resistance in glioblastoma
by: McFaline-Figueroa, José L
Published: (2014)

A chemical biology approach reveals a dependency of glioblastoma on biotin distribution
by: Yoon, Jeehyun, et al.
Published: (2022)

Development and mechanistic analysis of in vivo liposomal nanoparticle delivery of siRNA and mRNA
by: Dorkin, J. Robert (Joseph Robert)
Published: (2016)

Quantitative analysis of signaling networks in proneural glioblastoma
by: Lescarbeau, Rebecca S. (Rebecca Susan)
Published: (2015)

p53-independent regulation of p21Waf1/Cip1 expression and senescence by PRMT6
by: Phalke, Sameer, et al.
Published: (2013)

Kainate receptors mediate regulated exocytosis of secretory phospholipase A2 in SH-SY5Y neuroblastoma cells
by: Farooqui, Akhlaq A., et al.
Published: (2013)

Transcription elongation factors represent in vivo cancer dependencies in glioblastoma
by: Miller, Tyler E., et al.
Published: (2018)

Identification of novel branch points reveals insights into RNA processing
by: Gould, Genevieve Michelle
Published: (2016)

A Targeted RNA Interference Screen Reveals Novel Epigenetic Factors That Regulate Herpesviral Gene Expression
by: Oh, Hyung Suk, et al.
Published: (2014)

Genetic screens in vivo using the CRISPR/Cas9 system
by: Ellis, Donald Christian
Published: (2017)

Multivariate Perturbation of a Growth Factor-Cytokine Signalling Network Reveals Complex Systemic Responses in Glioblastoma Cells
by: Tang, Yew Chung, et al.
Published: (2007)

Profiling dynamic chromatome reveals HP1BP3 as a key regulator of cell cycle and hypoxia cancer progression
by: Bamaprasad Dutta
Published: (2014)

RNA polymerase II holoenzyme components and regulation
by: Wilson, Christopher J. (Christopher John), 1971-
Published: (2014)

Regulation of yeast development by mRNA methylation
by: Agarwala, Sudeep D
Published: (2012)

Targeting PRMT5 impairs cancer proliferation through splicing but promotes state shifts that enable resistance and disease progression
by: Fowler, Colin E.
Published: (2024)

Transcription factors interact with RNA to regulate genes
by: Oksuz, Ozgur, et al.
Published: (2023)

Genome-wide probing of RNA structure reveals active unfolding of mRNA structures in vivo
by: Rouskin, Silvi, et al.
Published: (2016)

Understanding regulation of mRNA by RNA binding proteins
by: Robertson, Alexander De Jong
Published: (2014)

SirT1 regulates bone mass in vivo through regulation of osteoblast and osteoclast differentiation
by: Zainabadi, Kayvan
Published: (2009)

Exploration of icariin analog structure space reveals key features driving potent inhibition of human phosphodiesterase-5
by: Chan, Yasmin, et al.
Published: (2020)

High-resolution HDX-MS reveals distinct mechanisms of RNA recognition and activation by RIG-I and MDA5
by: Liu, Chuan-Fa, et al.
Published: (2015)