Tectorial Membrane Traveling Waves Underlie Sharp Auditory Tuning in Humans
Our ability to understand speech requires neural tuning with high frequency resolution, but the peripheral mechanisms underlying sharp tuning in humans remain unclear. Sharp tuning in genetically modified mice has been attributed to decreases in spread of excitation of tectorial membrane traveling w...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | en_US |
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Elsevier
2017
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| Online Access: | http://hdl.handle.net/1721.1/111590 https://orcid.org/0000-0003-3369-5067 https://orcid.org/0000-0003-0622-1333 https://orcid.org/0000-0001-6309-0910 |
| _version_ | 1811071529309437952 |
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| author | Nakajima, Hideko H. Farrahi, Shirin Ghaffari, Roozbeh Sellon, Jonathan Blake Freeman, Dennis M. |
| author2 | Harvard University--MIT Division of Health Sciences and Technology |
| author_facet | Harvard University--MIT Division of Health Sciences and Technology Nakajima, Hideko H. Farrahi, Shirin Ghaffari, Roozbeh Sellon, Jonathan Blake Freeman, Dennis M. |
| author_sort | Nakajima, Hideko H. |
| collection | MIT |
| description | Our ability to understand speech requires neural tuning with high frequency resolution, but the peripheral mechanisms underlying sharp tuning in humans remain unclear. Sharp tuning in genetically modified mice has been attributed to decreases in spread of excitation of tectorial membrane traveling waves. Here we show that the spread of excitation of tectorial membrane waves is similar in humans and mice, although the mechanical excitation spans fewer frequencies in humans—suggesting a possible mechanism for sharper tuning. |
| first_indexed | 2024-09-23T08:52:38Z |
| format | Article |
| id | mit-1721.1/111590 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T08:52:38Z |
| publishDate | 2017 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/1115902022-09-30T11:51:02Z Tectorial Membrane Traveling Waves Underlie Sharp Auditory Tuning in Humans Nakajima, Hideko H. Farrahi, Shirin Ghaffari, Roozbeh Sellon, Jonathan Blake Freeman, Dennis M. Harvard University--MIT Division of Health Sciences and Technology Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology. Research Laboratory of Electronics Farrahi, Shirin Ghaffari, Roozbeh Sellon, Jonathan Blake Freeman, Dennis M. Our ability to understand speech requires neural tuning with high frequency resolution, but the peripheral mechanisms underlying sharp tuning in humans remain unclear. Sharp tuning in genetically modified mice has been attributed to decreases in spread of excitation of tectorial membrane traveling waves. Here we show that the spread of excitation of tectorial membrane waves is similar in humans and mice, although the mechanical excitation spans fewer frequencies in humans—suggesting a possible mechanism for sharper tuning. National Institutes of Health (U.S.) (Grant R01-DC00238) 2017-09-18T15:10:04Z 2017-09-18T15:10:04Z 2016-08 2016-05 Article http://purl.org/eprint/type/JournalArticle 0006-3495 1542-0086 http://hdl.handle.net/1721.1/111590 Farrahi, Shirin et al. “Tectorial Membrane Traveling Waves Underlie Sharp Auditory Tuning in Humans.” Biophysical Journal 111, 5 (September 2016): 921–924 © 2016 Biophysical Society https://orcid.org/0000-0003-3369-5067 https://orcid.org/0000-0003-0622-1333 https://orcid.org/0000-0001-6309-0910 en_US http://dx.doi.org/10.1016/j.bpj.2016.07.038 Biophysical Journal Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier Elsevier |
| spellingShingle | Nakajima, Hideko H. Farrahi, Shirin Ghaffari, Roozbeh Sellon, Jonathan Blake Freeman, Dennis M. Tectorial Membrane Traveling Waves Underlie Sharp Auditory Tuning in Humans |
| title | Tectorial Membrane Traveling Waves Underlie Sharp Auditory Tuning in Humans |
| title_full | Tectorial Membrane Traveling Waves Underlie Sharp Auditory Tuning in Humans |
| title_fullStr | Tectorial Membrane Traveling Waves Underlie Sharp Auditory Tuning in Humans |
| title_full_unstemmed | Tectorial Membrane Traveling Waves Underlie Sharp Auditory Tuning in Humans |
| title_short | Tectorial Membrane Traveling Waves Underlie Sharp Auditory Tuning in Humans |
| title_sort | tectorial membrane traveling waves underlie sharp auditory tuning in humans |
| url | http://hdl.handle.net/1721.1/111590 https://orcid.org/0000-0003-3369-5067 https://orcid.org/0000-0003-0622-1333 https://orcid.org/0000-0001-6309-0910 |
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