Calibrating genomic and allelic coverage bias in single-cell sequencing

Calibrating genomic and allelic coverage bias in single-cell sequencing

Artifacts introduced in whole-genome amplification (WGA) make it difficult to derive accurate genomic information from single-cell genomes and require different analytical strategies from bulk genome analysis. Here, we describe statistical methods to quantitatively assess the amplification bias resu...

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Bibliographic Details
Main Authors: Zhang, Cheng-Zhong, Francis, Joshua, Cornils, Hauke, Jung, Joonil, Maire, Cecile, Ligon, Keith L., Meyerson, Matthew, Adalsteinsson, Viktor A., Love, John C
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering
Format: Article
Language:en_US
Published: Nature Publishing Group 2017
Online Access:http://hdl.handle.net/1721.1/111665
https://orcid.org/0000-0003-4555-2485
https://orcid.org/0000-0003-0921-3144

Internet

http://hdl.handle.net/1721.1/111665
https://orcid.org/0000-0003-4555-2485
https://orcid.org/0000-0003-0921-3144

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