Functional differences between PD-1⁺ and PD-1⁻CD4⁺ effector T cells in healthy donors and patients with glioblastoma multiforme

Functional differences between PD-1⁺ and PD-1⁻CD4⁺ effector T cells in healthy donors and patients with glioblastoma multiforme

mmune checkpoint inhibitors targeting programmed cell death protein 1 (PD-1) have been highly successful in the treatment of cancer. While PD-1 expression has been widely investigated, its role in CD4⁺ effector T cells in the setting of health and cancer remains unclear, particularly in the setting...

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Bibliographic Details
Main Authors: Hernandez, Amanda L., Lowther, Daniel E., Lucca, Liliana E., Lerner, Benjamin A., Gunel, Murat, Raddassi, Khadir, Coric, Vlad, Hafler, David A., Thomas, Brittany A., Love, John C
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Public Library of Science 2017
Online Access:http://hdl.handle.net/1721.1/111673
https://orcid.org/0000-0002-5962-9570
https://orcid.org/0000-0003-0921-3144

Internet

http://hdl.handle.net/1721.1/111673
https://orcid.org/0000-0002-5962-9570
https://orcid.org/0000-0003-0921-3144

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