Lack of Responsiveness during the Onset and Offset of Sevoflurane Anesthesia Is Associated with Decreased Awake-Alpha Oscillation Power
Anesthetic drugs are typically administered to induce altered states of arousal that range from sedation to general anesthesia (GA). Systems neuroscience studies are currently being used to investigate the neural circuit mechanisms of anesthesia-induced altered arousal states. These studies suggest...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Published: |
Frontiers Research Foundation
2017
|
| Online Access: | http://hdl.handle.net/1721.1/112114 https://orcid.org/0000-0003-2668-7819 |
| _version_ | 1811068659260456960 |
|---|---|
| author | Pavone, Kara J. Su, Lijuan Gao, Lei Eromo, Ersne Vazquez, Rafael Rhee, James Hobbs, Lauren E. Ibala, Reine Demircioglu, Gizem Purdon, Patrick L. Akeju, Oluwaseun Brown, Emery Neal |
| author2 | Massachusetts Institute of Technology. Institute for Medical Engineering & Science |
| author_facet | Massachusetts Institute of Technology. Institute for Medical Engineering & Science Pavone, Kara J. Su, Lijuan Gao, Lei Eromo, Ersne Vazquez, Rafael Rhee, James Hobbs, Lauren E. Ibala, Reine Demircioglu, Gizem Purdon, Patrick L. Akeju, Oluwaseun Brown, Emery Neal |
| author_sort | Pavone, Kara J. |
| collection | MIT |
| description | Anesthetic drugs are typically administered to induce altered states of arousal that range from sedation to general anesthesia (GA). Systems neuroscience studies are currently being used to investigate the neural circuit mechanisms of anesthesia-induced altered arousal states. These studies suggest that by disrupting the oscillatory dynamics that are associated with arousal states, anesthesia-induced oscillations are a putative mechanism through which anesthetic drugs produce altered states of arousal. However, an empirical clinical observation is that even at relatively stable anesthetic doses, patients are sometimes intermittently responsive to verbal commands during states of light sedation. During these periods, prominent anesthesia-induced neural oscillations such as slow-delta (0.1–4 Hz) oscillations are notably absent. Neural correlates of intermittent responsiveness during light sedation have been insufficiently investigated. A principled understanding of the neural correlates of intermittent responsiveness may fundamentally advance our understanding of neural dynamics that are essential for maintaining arousal states, and how they are disrupted by anesthetics. Therefore, we performed a high-density (128 channels) electroencephalogram (EEG) study (n = 8) of sevoflurane-induced altered arousal in healthy volunteers. We administered temporally precise behavioral stimuli every 5 s to assess responsiveness. Here, we show that decreased eyes-closed, awake-alpha (8–12 Hz) oscillation power is associated with lack of responsiveness during sevoflurane effect-onset and -offset. We also show that anteriorization—the transition from occipitally dominant awake-alpha oscillations to frontally dominant anesthesia induced-alpha oscillations—is not a binary phenomenon. Rather, we suggest that periods, which were defined by lack of responsiveness, represent an intermediate brain state. We conclude that awake-alpha oscillation, previously thought to be an idling rhythm, is associated with responsiveness to behavioral stimuli. |
| first_indexed | 2024-09-23T07:59:13Z |
| format | Article |
| id | mit-1721.1/112114 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T07:59:13Z |
| publishDate | 2017 |
| publisher | Frontiers Research Foundation |
| record_format | dspace |
| spelling | mit-1721.1/1121142024-03-20T19:46:48Z Lack of Responsiveness during the Onset and Offset of Sevoflurane Anesthesia Is Associated with Decreased Awake-Alpha Oscillation Power Pavone, Kara J. Su, Lijuan Gao, Lei Eromo, Ersne Vazquez, Rafael Rhee, James Hobbs, Lauren E. Ibala, Reine Demircioglu, Gizem Purdon, Patrick L. Akeju, Oluwaseun Brown, Emery Neal Massachusetts Institute of Technology. Institute for Medical Engineering & Science Harvard University--MIT Division of Health Sciences and Technology Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Brown, Emery Neal Anesthetic drugs are typically administered to induce altered states of arousal that range from sedation to general anesthesia (GA). Systems neuroscience studies are currently being used to investigate the neural circuit mechanisms of anesthesia-induced altered arousal states. These studies suggest that by disrupting the oscillatory dynamics that are associated with arousal states, anesthesia-induced oscillations are a putative mechanism through which anesthetic drugs produce altered states of arousal. However, an empirical clinical observation is that even at relatively stable anesthetic doses, patients are sometimes intermittently responsive to verbal commands during states of light sedation. During these periods, prominent anesthesia-induced neural oscillations such as slow-delta (0.1–4 Hz) oscillations are notably absent. Neural correlates of intermittent responsiveness during light sedation have been insufficiently investigated. A principled understanding of the neural correlates of intermittent responsiveness may fundamentally advance our understanding of neural dynamics that are essential for maintaining arousal states, and how they are disrupted by anesthetics. Therefore, we performed a high-density (128 channels) electroencephalogram (EEG) study (n = 8) of sevoflurane-induced altered arousal in healthy volunteers. We administered temporally precise behavioral stimuli every 5 s to assess responsiveness. Here, we show that decreased eyes-closed, awake-alpha (8–12 Hz) oscillation power is associated with lack of responsiveness during sevoflurane effect-onset and -offset. We also show that anteriorization—the transition from occipitally dominant awake-alpha oscillations to frontally dominant anesthesia induced-alpha oscillations—is not a binary phenomenon. Rather, we suggest that periods, which were defined by lack of responsiveness, represent an intermediate brain state. We conclude that awake-alpha oscillation, previously thought to be an idling rhythm, is associated with responsiveness to behavioral stimuli. National Institutes of Health (U.S.) (Grant R01 AG053582) National Institutes of Health (U.S.) (Grant P01 GM118629) 2017-11-01T17:53:10Z 2017-11-01T17:53:10Z 2017-05 2017-10-26T18:03:20Z Article http://purl.org/eprint/type/JournalArticle 1662-5137 http://hdl.handle.net/1721.1/112114 Pavone, Kara J. et al. “Lack of Responsiveness During the Onset and Offset of Sevoflurane Anesthesia Is Associated with Decreased Awake-Alpha Oscillation Power.” Frontiers in Systems Neuroscience 11 (May 2017) © 2017 Pavone, Su et al https://orcid.org/0000-0003-2668-7819 http://dx.doi.org/10.3389/fnsys.2017.00038 Frontiers in Systems Neuroscience Creative Commons Attribution 4.0 International License http://creativecommons.org/licenses/by/4.0/ application/pdf Frontiers Research Foundation Frontiers |
| spellingShingle | Pavone, Kara J. Su, Lijuan Gao, Lei Eromo, Ersne Vazquez, Rafael Rhee, James Hobbs, Lauren E. Ibala, Reine Demircioglu, Gizem Purdon, Patrick L. Akeju, Oluwaseun Brown, Emery Neal Lack of Responsiveness during the Onset and Offset of Sevoflurane Anesthesia Is Associated with Decreased Awake-Alpha Oscillation Power |
| title | Lack of Responsiveness during the Onset and Offset of Sevoflurane Anesthesia Is Associated with Decreased Awake-Alpha Oscillation Power |
| title_full | Lack of Responsiveness during the Onset and Offset of Sevoflurane Anesthesia Is Associated with Decreased Awake-Alpha Oscillation Power |
| title_fullStr | Lack of Responsiveness during the Onset and Offset of Sevoflurane Anesthesia Is Associated with Decreased Awake-Alpha Oscillation Power |
| title_full_unstemmed | Lack of Responsiveness during the Onset and Offset of Sevoflurane Anesthesia Is Associated with Decreased Awake-Alpha Oscillation Power |
| title_short | Lack of Responsiveness during the Onset and Offset of Sevoflurane Anesthesia Is Associated with Decreased Awake-Alpha Oscillation Power |
| title_sort | lack of responsiveness during the onset and offset of sevoflurane anesthesia is associated with decreased awake alpha oscillation power |
| url | http://hdl.handle.net/1721.1/112114 https://orcid.org/0000-0003-2668-7819 |
| work_keys_str_mv | AT pavonekaraj lackofresponsivenessduringtheonsetandoffsetofsevofluraneanesthesiaisassociatedwithdecreasedawakealphaoscillationpower AT sulijuan lackofresponsivenessduringtheonsetandoffsetofsevofluraneanesthesiaisassociatedwithdecreasedawakealphaoscillationpower AT gaolei lackofresponsivenessduringtheonsetandoffsetofsevofluraneanesthesiaisassociatedwithdecreasedawakealphaoscillationpower AT eromoersne lackofresponsivenessduringtheonsetandoffsetofsevofluraneanesthesiaisassociatedwithdecreasedawakealphaoscillationpower AT vazquezrafael lackofresponsivenessduringtheonsetandoffsetofsevofluraneanesthesiaisassociatedwithdecreasedawakealphaoscillationpower AT rheejames lackofresponsivenessduringtheonsetandoffsetofsevofluraneanesthesiaisassociatedwithdecreasedawakealphaoscillationpower AT hobbslaurene lackofresponsivenessduringtheonsetandoffsetofsevofluraneanesthesiaisassociatedwithdecreasedawakealphaoscillationpower AT ibalareine lackofresponsivenessduringtheonsetandoffsetofsevofluraneanesthesiaisassociatedwithdecreasedawakealphaoscillationpower AT demircioglugizem lackofresponsivenessduringtheonsetandoffsetofsevofluraneanesthesiaisassociatedwithdecreasedawakealphaoscillationpower AT purdonpatrickl lackofresponsivenessduringtheonsetandoffsetofsevofluraneanesthesiaisassociatedwithdecreasedawakealphaoscillationpower AT akejuoluwaseun lackofresponsivenessduringtheonsetandoffsetofsevofluraneanesthesiaisassociatedwithdecreasedawakealphaoscillationpower AT brownemeryneal lackofresponsivenessduringtheonsetandoffsetofsevofluraneanesthesiaisassociatedwithdecreasedawakealphaoscillationpower |