Neural correlates of emotion acceptance vs worry or suppression in generalized anxiety disorder
Recent emotion dysregulationmodels of generalized anxiety disorder (GAD) propose chronic worry in GAD functions as a maladaptive attempt to regulate anxiety related to uncertain or unpredictable outcomes. Emotion acceptance is an adaptive emotion regulation strategy increasingly incorporated into ne...
| Main Authors: | , , , , |
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| Format: | Article |
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Oxford University Press (OUP)
2017
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| Online Access: | http://hdl.handle.net/1721.1/112143 https://orcid.org/0000-0003-1158-5692 |
| _version_ | 1811088804842307584 |
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| author | Ellard, Kristen K. Barlow, David H. Deckersbach, Thilo Whitfield-Gabrieli, Susan Gabrieli, John D. E. |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Ellard, Kristen K. Barlow, David H. Deckersbach, Thilo Whitfield-Gabrieli, Susan Gabrieli, John D. E. |
| author_sort | Ellard, Kristen K. |
| collection | MIT |
| description | Recent emotion dysregulationmodels of generalized anxiety disorder (GAD) propose chronic worry in GAD functions as a maladaptive attempt to regulate anxiety related to uncertain or unpredictable outcomes. Emotion acceptance is an adaptive emotion regulation strategy increasingly incorporated into newer cognitive behavioral therapy (CBT) approaches to GAD to counter chronic worry. The current study explores themechanisms of emotion acceptance as an alternate emotion regulation strategy to worry or emotion suppression using functionalmagnetic resonance imaging. Twenty-one female participants diagnosed with GAD followed counterbalanced instructions to regulate responses to personally relevant worry statements by engaging in either emotion acceptance, worry or emotion suppression. Emotion acceptance resulted in lower ratings of distress than worry and was associated with increased dorsal anterior cingulate cortex (dACC) activation and increased ventrolateral prefrontal cortex (VLPFC)-amygdala functional connectivity. In contrast, worry showed significantly greater distress ratings than acceptance or suppression and was associated with increased precuneus, VLPFC, amygdala and hippocampal activation. Suppression did not significantly differ fromacceptance in distress ratings or amygdala recruitment, but resulted in significantly greater insula and VLPFC activation and decreased VLPFC-amygdala functional connectivity. Emotion acceptance closely aligned with activation and connectivity patterns reported in studies of contextual extinction learning and mindful awareness. |
| first_indexed | 2024-09-23T14:07:49Z |
| format | Article |
| id | mit-1721.1/112143 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T14:07:49Z |
| publishDate | 2017 |
| publisher | Oxford University Press (OUP) |
| record_format | dspace |
| spelling | mit-1721.1/1121432022-09-28T18:44:16Z Neural correlates of emotion acceptance vs worry or suppression in generalized anxiety disorder Ellard, Kristen K. Barlow, David H. Deckersbach, Thilo Whitfield-Gabrieli, Susan Gabrieli, John D. E. Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences McGovern Institute for Brain Research at MIT Whitfield-Gabrieli, Susan Gabrieli, John D. E. Recent emotion dysregulationmodels of generalized anxiety disorder (GAD) propose chronic worry in GAD functions as a maladaptive attempt to regulate anxiety related to uncertain or unpredictable outcomes. Emotion acceptance is an adaptive emotion regulation strategy increasingly incorporated into newer cognitive behavioral therapy (CBT) approaches to GAD to counter chronic worry. The current study explores themechanisms of emotion acceptance as an alternate emotion regulation strategy to worry or emotion suppression using functionalmagnetic resonance imaging. Twenty-one female participants diagnosed with GAD followed counterbalanced instructions to regulate responses to personally relevant worry statements by engaging in either emotion acceptance, worry or emotion suppression. Emotion acceptance resulted in lower ratings of distress than worry and was associated with increased dorsal anterior cingulate cortex (dACC) activation and increased ventrolateral prefrontal cortex (VLPFC)-amygdala functional connectivity. In contrast, worry showed significantly greater distress ratings than acceptance or suppression and was associated with increased precuneus, VLPFC, amygdala and hippocampal activation. Suppression did not significantly differ fromacceptance in distress ratings or amygdala recruitment, but resulted in significantly greater insula and VLPFC activation and decreased VLPFC-amygdala functional connectivity. Emotion acceptance closely aligned with activation and connectivity patterns reported in studies of contextual extinction learning and mindful awareness. National Institute of Mental Health (U.S.) (Grant F31 MH084422) 2017-11-08T16:29:30Z 2017-11-08T16:29:30Z 2017-04 2017-02 2017-11-07T17:12:31Z Article http://purl.org/eprint/type/JournalArticle 1749-5016 1749-5024 http://hdl.handle.net/1721.1/112143 Ellard, Kristen K. et al. “Neural Correlates of Emotion Acceptance Vs Worry or Suppression in Generalized Anxiety Disorder.” Social Cognitive and Affective Neuroscience 12, 6 (April 2017): 1009–1021 © The Author https://orcid.org/0000-0003-1158-5692 http://dx.doi.org/10.1093/SCAN/NSX025 Social Cognitive and Affective Neuroscience Creative Commons Attribution-NonCommercial 4.0 International http://creativecommons.org/licenses/by-nc/4.0/ application/pdf Oxford University Press (OUP) Oxford University Press |
| spellingShingle | Ellard, Kristen K. Barlow, David H. Deckersbach, Thilo Whitfield-Gabrieli, Susan Gabrieli, John D. E. Neural correlates of emotion acceptance vs worry or suppression in generalized anxiety disorder |
| title | Neural correlates of emotion acceptance vs worry or suppression in generalized anxiety disorder |
| title_full | Neural correlates of emotion acceptance vs worry or suppression in generalized anxiety disorder |
| title_fullStr | Neural correlates of emotion acceptance vs worry or suppression in generalized anxiety disorder |
| title_full_unstemmed | Neural correlates of emotion acceptance vs worry or suppression in generalized anxiety disorder |
| title_short | Neural correlates of emotion acceptance vs worry or suppression in generalized anxiety disorder |
| title_sort | neural correlates of emotion acceptance vs worry or suppression in generalized anxiety disorder |
| url | http://hdl.handle.net/1721.1/112143 https://orcid.org/0000-0003-1158-5692 |
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