Altered functional connectivity in lesional peduncular hallucinosis with REM sleep behavior disorder
Brainstem lesions causing peduncular hallucinosis (PH) produce vivid visual hallucinations occasionally accompanied by sleep disorders. Overlapping brainstem regions modulate visual pathways and REM sleep functions via gating of thalamocortical networks. A 66-year-old man with paroxysmal atrial fibr...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | en_US |
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Elsevier
2017
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| Online Access: | http://hdl.handle.net/1721.1/112160 https://orcid.org/0000-0002-6979-6241 https://orcid.org/0000-0003-1158-5692 |
| _version_ | 1811095583197233152 |
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| author | Tie, Yanmei McGinnis, Scott M. Golby, Alexandra J. Geddes, Maiya Gabrieli, John D. E. Whitfield-Gabrieli, Susan |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Tie, Yanmei McGinnis, Scott M. Golby, Alexandra J. Geddes, Maiya Gabrieli, John D. E. Whitfield-Gabrieli, Susan |
| author_sort | Tie, Yanmei |
| collection | MIT |
| description | Brainstem lesions causing peduncular hallucinosis (PH) produce vivid visual hallucinations occasionally accompanied by sleep disorders. Overlapping brainstem regions modulate visual pathways and REM sleep functions via gating of thalamocortical networks. A 66-year-old man with paroxysmal atrial fibrillation developed abrupt–onset complex visual hallucinations with preserved insight and violent dream enactment behavior. Brain MRI showed restricted diffusion in the left rostrodorsal pons suggestive of an acute ischemic stroke. REM sleep behavior disorder (RBD) was diagnosed on polysomnography. We investigated the integrity of ponto-geniculate-occipital circuits with seed-based resting-state functional connectivity MRI (rs-fcMRI) in this patient compared to 46 controls. Rs-fcMRI revealed significantly reduced functional connectivity between the lesion and lateral geniculate nuclei (LGN), and between LGN and visual association cortex compared to controls. Conversely, functional connectivity between brainstem and visual association cortex, and between visual association cortex and prefrontal cortex (PFC) was significantly increased in the patient. Focal damage to the rostrodorsal pons is sufficient to cause RBD and PH in humans, suggesting an overlapping mechanism in both syndromes. This lesion produced a pattern of altered functional connectivity consistent with disrupted visual cortex connectivity via de-afferentation of thalamocortical pathways. |
| first_indexed | 2024-09-23T16:19:53Z |
| format | Article |
| id | mit-1721.1/112160 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T16:19:53Z |
| publishDate | 2017 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/1121602022-09-29T19:37:18Z Altered functional connectivity in lesional peduncular hallucinosis with REM sleep behavior disorder Tie, Yanmei McGinnis, Scott M. Golby, Alexandra J. Geddes, Maiya Gabrieli, John D. E. Whitfield-Gabrieli, Susan Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences McGovern Institute for Brain Research at MIT Geddes, Maiya Gabrieli, John D. E. Whitfield-Gabrieli, Susan Brainstem lesions causing peduncular hallucinosis (PH) produce vivid visual hallucinations occasionally accompanied by sleep disorders. Overlapping brainstem regions modulate visual pathways and REM sleep functions via gating of thalamocortical networks. A 66-year-old man with paroxysmal atrial fibrillation developed abrupt–onset complex visual hallucinations with preserved insight and violent dream enactment behavior. Brain MRI showed restricted diffusion in the left rostrodorsal pons suggestive of an acute ischemic stroke. REM sleep behavior disorder (RBD) was diagnosed on polysomnography. We investigated the integrity of ponto-geniculate-occipital circuits with seed-based resting-state functional connectivity MRI (rs-fcMRI) in this patient compared to 46 controls. Rs-fcMRI revealed significantly reduced functional connectivity between the lesion and lateral geniculate nuclei (LGN), and between LGN and visual association cortex compared to controls. Conversely, functional connectivity between brainstem and visual association cortex, and between visual association cortex and prefrontal cortex (PFC) was significantly increased in the patient. Focal damage to the rostrodorsal pons is sufficient to cause RBD and PH in humans, suggesting an overlapping mechanism in both syndromes. This lesion produced a pattern of altered functional connectivity consistent with disrupted visual cortex connectivity via de-afferentation of thalamocortical pathways. 2017-11-09T18:32:10Z 2017-11-09T18:32:10Z 2015-11 2015-08 Article http://purl.org/eprint/type/JournalArticle 0010-9452 http://hdl.handle.net/1721.1/112160 Geddes, Maiya R. et al. “Altered Functional Connectivity in Lesional Peduncular Hallucinosis with REM Sleep Behavior Disorder.” Cortex 74 (January 2016): 96–106 © 2015 Elsevier https://orcid.org/0000-0002-6979-6241 https://orcid.org/0000-0003-1158-5692 en_US http://dx.doi.org/10.1016/j.cortex.2015.10.015 Cortex Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier PMC |
| spellingShingle | Tie, Yanmei McGinnis, Scott M. Golby, Alexandra J. Geddes, Maiya Gabrieli, John D. E. Whitfield-Gabrieli, Susan Altered functional connectivity in lesional peduncular hallucinosis with REM sleep behavior disorder |
| title | Altered functional connectivity in lesional peduncular hallucinosis with REM sleep behavior disorder |
| title_full | Altered functional connectivity in lesional peduncular hallucinosis with REM sleep behavior disorder |
| title_fullStr | Altered functional connectivity in lesional peduncular hallucinosis with REM sleep behavior disorder |
| title_full_unstemmed | Altered functional connectivity in lesional peduncular hallucinosis with REM sleep behavior disorder |
| title_short | Altered functional connectivity in lesional peduncular hallucinosis with REM sleep behavior disorder |
| title_sort | altered functional connectivity in lesional peduncular hallucinosis with rem sleep behavior disorder |
| url | http://hdl.handle.net/1721.1/112160 https://orcid.org/0000-0002-6979-6241 https://orcid.org/0000-0003-1158-5692 |
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