Cortical gray-matter thinning is associated with age-related improvements on executive function tasks
Across development children show marked improvement in their executive functions (EFs), including the ability to hold information in working memory and to deploy cognitive control, allowing them to ignore prepotent responses in favor of newly learned behaviors. How does the brain support these age-r...
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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Elsevier
2017
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| Online Access: | http://hdl.handle.net/1721.1/112161 https://orcid.org/0000-0003-1158-5692 |
| _version_ | 1811069958386352128 |
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| author | Kharitonova, Maria Martin, Rebecca E. Sheridan, Margaret A. Gabrieli, John D. E. |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Kharitonova, Maria Martin, Rebecca E. Sheridan, Margaret A. Gabrieli, John D. E. |
| author_sort | Kharitonova, Maria |
| collection | MIT |
| description | Across development children show marked improvement in their executive functions (EFs), including the ability to hold information in working memory and to deploy cognitive control, allowing them to ignore prepotent responses in favor of newly learned behaviors. How does the brain support these age-related improvements? Age-related cortical gray-matter thinning, thought to result from selective pruning of inefficient synaptic connections and increases in myelination, may support age-related improvements in EFs. Here we used structural MRI to measure cortical thickness. We investigate the association between cortical thickness in three cortical regions of interest (ROIs), and age-related changes in cognitive control and working memory in 5–10 year old children. We found significant associations between reductions in cortical thickness and age-related improvements in performance on both working memory and cognitive control tasks. Moreover, we observed a dissociation between ROIs typically thought to underlie changes in cognitive control (right Inferior Frontal gyrus and Anterior Cingulate cortex) and age-related improvements in cognitive control, and ROIs for working memory (superior parietal cortex), and age-related changes in a working memory task. These data add to our growing understanding of how structural maturation of the brain supports vast behavioral changes in executive functions observed across childhood. |
| first_indexed | 2024-09-23T08:19:35Z |
| format | Article |
| id | mit-1721.1/112161 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T08:19:35Z |
| publishDate | 2017 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/1121612022-09-23T12:20:56Z Cortical gray-matter thinning is associated with age-related improvements on executive function tasks Kharitonova, Maria Martin, Rebecca E. Sheridan, Margaret A. Gabrieli, John D. E. Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Gabrieli, John D. E. Across development children show marked improvement in their executive functions (EFs), including the ability to hold information in working memory and to deploy cognitive control, allowing them to ignore prepotent responses in favor of newly learned behaviors. How does the brain support these age-related improvements? Age-related cortical gray-matter thinning, thought to result from selective pruning of inefficient synaptic connections and increases in myelination, may support age-related improvements in EFs. Here we used structural MRI to measure cortical thickness. We investigate the association between cortical thickness in three cortical regions of interest (ROIs), and age-related changes in cognitive control and working memory in 5–10 year old children. We found significant associations between reductions in cortical thickness and age-related improvements in performance on both working memory and cognitive control tasks. Moreover, we observed a dissociation between ROIs typically thought to underlie changes in cognitive control (right Inferior Frontal gyrus and Anterior Cingulate cortex) and age-related improvements in cognitive control, and ROIs for working memory (superior parietal cortex), and age-related changes in a working memory task. These data add to our growing understanding of how structural maturation of the brain supports vast behavioral changes in executive functions observed across childhood. 2017-11-09T18:38:20Z 2017-11-09T18:38:20Z 2013-07 2013-05 Article http://purl.org/eprint/type/JournalArticle 1878-9293 http://hdl.handle.net/1721.1/112161 Kharitonova, Maria, et al. “Cortical Gray-Matter Thinning Is Associated with Age-Related Improvements on Executive Function Tasks.” Developmental Cognitive Neuroscience 6 (October 2013): 61–71 © 2013 Elsevier https://orcid.org/0000-0003-1158-5692 en_US http://dx.doi.org/10.1016/j.dcn.2013.07.002 Developmental Cognitive Neuroscience Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier PMC |
| spellingShingle | Kharitonova, Maria Martin, Rebecca E. Sheridan, Margaret A. Gabrieli, John D. E. Cortical gray-matter thinning is associated with age-related improvements on executive function tasks |
| title | Cortical gray-matter thinning is associated with age-related improvements on executive function tasks |
| title_full | Cortical gray-matter thinning is associated with age-related improvements on executive function tasks |
| title_fullStr | Cortical gray-matter thinning is associated with age-related improvements on executive function tasks |
| title_full_unstemmed | Cortical gray-matter thinning is associated with age-related improvements on executive function tasks |
| title_short | Cortical gray-matter thinning is associated with age-related improvements on executive function tasks |
| title_sort | cortical gray matter thinning is associated with age related improvements on executive function tasks |
| url | http://hdl.handle.net/1721.1/112161 https://orcid.org/0000-0003-1158-5692 |
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