Functional Brain Basis of Hypnotizability
Context Focused hypnotic concentration is a model for brain control over sensation and behavior. Pain and anxiety can be effectively alleviated by hypnotic suggestion, which modulates activity in brain regions associated with focused attention, but the specific neural network underlying this phenome...
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| Format: | Article |
| Language: | en_US |
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American Medical Association
2017
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| Online Access: | http://hdl.handle.net/1721.1/112164 https://orcid.org/0000-0003-1158-5692 |
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| author | Hoeft, Fumiko Haas, Brian W. Bammer, Roland Menon, Vinod Spiegel, David Gabrieli, John D. E. Whitfield-Gabrieli, Susan |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Hoeft, Fumiko Haas, Brian W. Bammer, Roland Menon, Vinod Spiegel, David Gabrieli, John D. E. Whitfield-Gabrieli, Susan |
| author_sort | Hoeft, Fumiko |
| collection | MIT |
| description | Context Focused hypnotic concentration is a model for brain control over sensation and behavior. Pain and anxiety can be effectively alleviated by hypnotic suggestion, which modulates activity in brain regions associated with focused attention, but the specific neural network underlying this phenomenon is not known.
Objective To investigate the brain basis of hypnotizability.
Design Cross-sectional, in vivo neuroimaging study performed from November 2005 through July 2006.
Setting Academic medical center at Stanford University School of Medicine.
Patients Twelve adults with high and 12 adults with low hypnotizability.
Main Outcome Measures Functional magnetic resonance imaging to measure functional connectivity networks at rest, including default-mode, salience, and executive-control networks; structural T1 magnetic resonance imaging to measure regional gray and white matter volumes; and diffusion tensor imaging to measure white matter microstructural integrity.
Results High compared with low hypnotizable individuals had greater functional connectivity between the left dorsolateral prefrontal cortex, an executive-control region of the brain, and the salience network composed of the dorsal anterior cingulate cortex, anterior insula, amygdala, and ventral striatum, involved in detecting, integrating, and filtering relevant somatic, autonomic, and emotional information using independent component analysis. Seed-based analysis confirmed elevated functional coupling between the dorsal anterior cingulate cortex and the dorsolateral prefrontal cortex in high compared with low hypnotizable individuals. These functional differences were not due to any variation in brain structure in these regions, including regional gray and white matter volumes and white matter microstructure.
Conclusions Our results provide novel evidence that altered functional connectivity in the dorsolateral prefrontal cortex and dorsal anterior cingulate cortex may underlie hypnotizability. Future studies focusing on how these functional networks change and interact during hypnosis are warranted. |
| first_indexed | 2024-09-23T09:01:29Z |
| format | Article |
| id | mit-1721.1/112164 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T09:01:29Z |
| publishDate | 2017 |
| publisher | American Medical Association |
| record_format | dspace |
| spelling | mit-1721.1/1121642022-09-26T09:56:53Z Functional Brain Basis of Hypnotizability Hoeft, Fumiko Haas, Brian W. Bammer, Roland Menon, Vinod Spiegel, David Gabrieli, John D. E. Whitfield-Gabrieli, Susan Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Gabrieli, John D. E. Whitfield-Gabrieli, Susan Context Focused hypnotic concentration is a model for brain control over sensation and behavior. Pain and anxiety can be effectively alleviated by hypnotic suggestion, which modulates activity in brain regions associated with focused attention, but the specific neural network underlying this phenomenon is not known. Objective To investigate the brain basis of hypnotizability. Design Cross-sectional, in vivo neuroimaging study performed from November 2005 through July 2006. Setting Academic medical center at Stanford University School of Medicine. Patients Twelve adults with high and 12 adults with low hypnotizability. Main Outcome Measures Functional magnetic resonance imaging to measure functional connectivity networks at rest, including default-mode, salience, and executive-control networks; structural T1 magnetic resonance imaging to measure regional gray and white matter volumes; and diffusion tensor imaging to measure white matter microstructural integrity. Results High compared with low hypnotizable individuals had greater functional connectivity between the left dorsolateral prefrontal cortex, an executive-control region of the brain, and the salience network composed of the dorsal anterior cingulate cortex, anterior insula, amygdala, and ventral striatum, involved in detecting, integrating, and filtering relevant somatic, autonomic, and emotional information using independent component analysis. Seed-based analysis confirmed elevated functional coupling between the dorsal anterior cingulate cortex and the dorsolateral prefrontal cortex in high compared with low hypnotizable individuals. These functional differences were not due to any variation in brain structure in these regions, including regional gray and white matter volumes and white matter microstructure. Conclusions Our results provide novel evidence that altered functional connectivity in the dorsolateral prefrontal cortex and dorsal anterior cingulate cortex may underlie hypnotizability. Future studies focusing on how these functional networks change and interact during hypnosis are warranted. 2017-11-09T19:03:11Z 2017-11-09T19:03:11Z 2012-10 Article http://purl.org/eprint/type/JournalArticle 0003-990X http://hdl.handle.net/1721.1/112164 Hoeft, Fumiko et al. “Functional Brain Basis of Hypnotizability.” Archives of General Psychiatry 69, 10 (October 2012): 1064-1072 © 2012 American Medical Association https://orcid.org/0000-0003-1158-5692 en_US http://dx.doi.org/10.1001/archgenpsychiatry.2011.2190 Archives of General Psychiatry Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf American Medical Association PMC |
| spellingShingle | Hoeft, Fumiko Haas, Brian W. Bammer, Roland Menon, Vinod Spiegel, David Gabrieli, John D. E. Whitfield-Gabrieli, Susan Functional Brain Basis of Hypnotizability |
| title | Functional Brain Basis of Hypnotizability |
| title_full | Functional Brain Basis of Hypnotizability |
| title_fullStr | Functional Brain Basis of Hypnotizability |
| title_full_unstemmed | Functional Brain Basis of Hypnotizability |
| title_short | Functional Brain Basis of Hypnotizability |
| title_sort | functional brain basis of hypnotizability |
| url | http://hdl.handle.net/1721.1/112164 https://orcid.org/0000-0003-1158-5692 |
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