Connectivity precedes function in the development of the visual word form area
What determines the cortical location at which a given functionally specific region will arise in development? We tested the hypothesis that functionally specific regions develop in their characteristic locations because of pre-existing differences in the extrinsic connectivity of that region to the...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | en_US |
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Nature Publishing Group
2017
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| Online Access: | http://hdl.handle.net/1721.1/112165 https://orcid.org/0000-0002-2191-0340 https://orcid.org/0000-0003-1158-5692 https://orcid.org/0000-0003-3853-7885 |
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| author | Osher, David E Norton, Elizabeth S Youssoufian, Deanna A Feather, Jenelle Gaab, Nadine Saygin, Zeynep M. Beach, Sara Dawley Gabrieli, John D. E. Kanwisher, Nancy |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Osher, David E Norton, Elizabeth S Youssoufian, Deanna A Feather, Jenelle Gaab, Nadine Saygin, Zeynep M. Beach, Sara Dawley Gabrieli, John D. E. Kanwisher, Nancy |
| author_sort | Osher, David E |
| collection | MIT |
| description | What determines the cortical location at which a given functionally specific region will arise in development? We tested the hypothesis that functionally specific regions develop in their characteristic locations because of pre-existing differences in the extrinsic connectivity of that region to the rest of the brain. We exploited the visual word form area (VWFA) as a test case, scanning children with diffusion and functional imaging at age 5, before they learned to read, and at age 8, after they learned to read. We found the VWFA developed functionally in this interval and that its location in a particular child at age 8 could be predicted from that child's connectivity fingerprints (but not functional responses) at age 5. These results suggest that early connectivity instructs the functional development of the VWFA, possibly reflecting a general mechanism of cortical development. |
| first_indexed | 2024-09-23T14:19:31Z |
| format | Article |
| id | mit-1721.1/112165 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T14:19:31Z |
| publishDate | 2017 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | mit-1721.1/1121652022-09-29T08:43:18Z Connectivity precedes function in the development of the visual word form area Osher, David E Norton, Elizabeth S Youssoufian, Deanna A Feather, Jenelle Gaab, Nadine Saygin, Zeynep M. Beach, Sara Dawley Gabrieli, John D. E. Kanwisher, Nancy Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences McGovern Institute for Brain Research at MIT Saygin, Zeynep M. Beach, Sara Dawley Gabrieli, John D. E. Kanwisher, Nancy What determines the cortical location at which a given functionally specific region will arise in development? We tested the hypothesis that functionally specific regions develop in their characteristic locations because of pre-existing differences in the extrinsic connectivity of that region to the rest of the brain. We exploited the visual word form area (VWFA) as a test case, scanning children with diffusion and functional imaging at age 5, before they learned to read, and at age 8, after they learned to read. We found the VWFA developed functionally in this interval and that its location in a particular child at age 8 could be predicted from that child's connectivity fingerprints (but not functional responses) at age 5. These results suggest that early connectivity instructs the functional development of the VWFA, possibly reflecting a general mechanism of cortical development. National Institutes of Health (U.S.) (Grant F32HD079169) Eunice Kennedy Shriver National Institute of Child Health and Human Development (U.S.) (Grant F32HD079169) National Institutes of Health (U.S.) (Grant R01HD067312) Eunice Kennedy Shriver National Institute of Child Health and Human Development (U.S.) (Grant R01HD067312) 2017-11-09T19:13:08Z 2017-11-09T19:13:08Z 2016-08 2016-01 Article http://purl.org/eprint/type/JournalArticle 1097-6256 1546-1726 http://hdl.handle.net/1721.1/112165 Saygin, Zeynep M. “Connectivity Precedes Function in the Development of the Visual Word Form Area.” Nature Neuroscience 19, 9 (August 2016): 1250–1255 © 2016 Nature Publishing Group https://orcid.org/0000-0002-2191-0340 https://orcid.org/0000-0003-1158-5692 https://orcid.org/0000-0003-3853-7885 en_US http://dx.doi.org/10.1038/nn.4354 Nature Neuroscience Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Nature Publishing Group PMC |
| spellingShingle | Osher, David E Norton, Elizabeth S Youssoufian, Deanna A Feather, Jenelle Gaab, Nadine Saygin, Zeynep M. Beach, Sara Dawley Gabrieli, John D. E. Kanwisher, Nancy Connectivity precedes function in the development of the visual word form area |
| title | Connectivity precedes function in the development of the visual word form area |
| title_full | Connectivity precedes function in the development of the visual word form area |
| title_fullStr | Connectivity precedes function in the development of the visual word form area |
| title_full_unstemmed | Connectivity precedes function in the development of the visual word form area |
| title_short | Connectivity precedes function in the development of the visual word form area |
| title_sort | connectivity precedes function in the development of the visual word form area |
| url | http://hdl.handle.net/1721.1/112165 https://orcid.org/0000-0002-2191-0340 https://orcid.org/0000-0003-1158-5692 https://orcid.org/0000-0003-3853-7885 |
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