Neurobiology of rodent self-grooming and its value for translational neuroscience
Self-grooming is a complex innate behaviour with an evolutionarily conserved sequencing pattern and is one of the most frequently performed behavioural activities in rodents. In this Review, we discuss the neurobiology of rodent self-grooming, and we highlight studies of rodent models of neuropsychi...
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| Format: | Article |
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Nature Publishing Group
2017
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| Online Access: | http://hdl.handle.net/1721.1/112180 https://orcid.org/0000-0002-4326-7720 |
| _version_ | 1826213742752301056 |
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| author | Kalueff, Allan V. Stewart, Adam Michael Song, Cai Berridge, Kent C. Fentress, John C. Graybiel, Ann M |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Kalueff, Allan V. Stewart, Adam Michael Song, Cai Berridge, Kent C. Fentress, John C. Graybiel, Ann M |
| author_sort | Kalueff, Allan V. |
| collection | MIT |
| description | Self-grooming is a complex innate behaviour with an evolutionarily conserved sequencing pattern and is one of the most frequently performed behavioural activities in rodents. In this Review, we discuss the neurobiology of rodent self-grooming, and we highlight studies of rodent models of neuropsychiatric disorders-including models of autism spectrum disorder and obsessive compulsive disorder-that have assessed self-grooming phenotypes. We suggest that rodent self-grooming may be a useful measure of repetitive behaviour in such models, and therefore of value to translational psychiatry. Assessment of rodent self-grooming may also be useful for understanding the neural circuits that are involved in complex sequential patterns of action. |
| first_indexed | 2024-09-23T15:54:06Z |
| format | Article |
| id | mit-1721.1/112180 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T15:54:06Z |
| publishDate | 2017 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | mit-1721.1/1121802022-09-29T16:55:36Z Neurobiology of rodent self-grooming and its value for translational neuroscience Kalueff, Allan V. Stewart, Adam Michael Song, Cai Berridge, Kent C. Fentress, John C. Graybiel, Ann M Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences McGovern Institute for Brain Research at MIT Graybiel, Ann M Self-grooming is a complex innate behaviour with an evolutionarily conserved sequencing pattern and is one of the most frequently performed behavioural activities in rodents. In this Review, we discuss the neurobiology of rodent self-grooming, and we highlight studies of rodent models of neuropsychiatric disorders-including models of autism spectrum disorder and obsessive compulsive disorder-that have assessed self-grooming phenotypes. We suggest that rodent self-grooming may be a useful measure of repetitive behaviour in such models, and therefore of value to translational psychiatry. Assessment of rodent self-grooming may also be useful for understanding the neural circuits that are involved in complex sequential patterns of action. National Institutes of Health (U.S.) (Grant NS025529) National Institutes of Health (U.S.) (Grant HD028341) National Institutes of Health (U.S.) (Grant MH060379) 2017-11-14T16:49:33Z 2017-11-14T16:49:33Z 2017-11-14 2017-11-09T16:53:06Z Article http://purl.org/eprint/type/JournalArticle 1471-003X 1471-0048 http://hdl.handle.net/1721.1/112180 Kalueff, Allan V. “Neurobiology of Rodent Self-Grooming and Its Value for Translational Neuroscience.” Nature Reviews Neuroscience 17, 1 (December 2015): 45–59 © 2016 Macmillan Publishers Limited https://orcid.org/0000-0002-4326-7720 http://dx.doi.org/10.1038/NRN.2015.8 Nature Reviews Neuroscience Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Nature Publishing Group PMC |
| spellingShingle | Kalueff, Allan V. Stewart, Adam Michael Song, Cai Berridge, Kent C. Fentress, John C. Graybiel, Ann M Neurobiology of rodent self-grooming and its value for translational neuroscience |
| title | Neurobiology of rodent self-grooming and its value for translational neuroscience |
| title_full | Neurobiology of rodent self-grooming and its value for translational neuroscience |
| title_fullStr | Neurobiology of rodent self-grooming and its value for translational neuroscience |
| title_full_unstemmed | Neurobiology of rodent self-grooming and its value for translational neuroscience |
| title_short | Neurobiology of rodent self-grooming and its value for translational neuroscience |
| title_sort | neurobiology of rodent self grooming and its value for translational neuroscience |
| url | http://hdl.handle.net/1721.1/112180 https://orcid.org/0000-0002-4326-7720 |
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