A Neural Mechanism for Sensing and Reproducing a Time Interval
Timing plays a crucial role in sensorimotor function. However, the neural mechanisms that enable the brain to flexibly measure and reproduce time intervals are not known. We recorded neural activity in parietal cortex of monkeys in a time reproduction task. Monkeys were trained to measure and immedi...
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| Format: | Article |
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Elsevier
2017
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| Online Access: | http://hdl.handle.net/1721.1/112188 |
| _version_ | 1810984199102922752 |
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| author | Shadlen, Michael N. Jazayeri, Mehrdad |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Shadlen, Michael N. Jazayeri, Mehrdad |
| author_sort | Shadlen, Michael N. |
| collection | MIT |
| description | Timing plays a crucial role in sensorimotor function. However, the neural mechanisms that enable the brain to flexibly measure and reproduce time intervals are not known. We recorded neural activity in parietal cortex of monkeys in a time reproduction task. Monkeys were trained to measure and immediately afterward reproduce different sample intervals. While measuring an interval, neural responses had a nonlinear profile that increased with the duration of the sample interval. Activity was reset during the transition from measurement to production and was followed by a ramping activity whose slope encoded the previously measured sample interval. We found that firing rates at the end of the measurement epoch were correlated with both the slope of the ramp and the monkey's corresponding production interval on a trial-by-trial basis. Analysis of response dynamics further linked the rate of change of firing rates in the measurement epoch to the slope of the ramp in the production epoch. These observations suggest that, during time reproduction, an interval is measured prospectively in relation to the desired motor plan to reproduce that interval. |
| first_indexed | 2024-09-23T10:58:38Z |
| format | Article |
| id | mit-1721.1/112188 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T10:58:38Z |
| publishDate | 2017 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/1121882022-09-27T16:20:27Z A Neural Mechanism for Sensing and Reproducing a Time Interval Shadlen, Michael N. Jazayeri, Mehrdad Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences McGovern Institute for Brain Research at MIT Jazayeri, Mehrdad Timing plays a crucial role in sensorimotor function. However, the neural mechanisms that enable the brain to flexibly measure and reproduce time intervals are not known. We recorded neural activity in parietal cortex of monkeys in a time reproduction task. Monkeys were trained to measure and immediately afterward reproduce different sample intervals. While measuring an interval, neural responses had a nonlinear profile that increased with the duration of the sample interval. Activity was reset during the transition from measurement to production and was followed by a ramping activity whose slope encoded the previously measured sample interval. We found that firing rates at the end of the measurement epoch were correlated with both the slope of the ramp and the monkey's corresponding production interval on a trial-by-trial basis. Analysis of response dynamics further linked the rate of change of firing rates in the measurement epoch to the slope of the ramp in the production epoch. These observations suggest that, during time reproduction, an interval is measured prospectively in relation to the desired motor plan to reproduce that interval. 2017-11-14T19:04:03Z 2017-11-14T19:04:03Z 2015-10 2015-08 2017-11-13T18:42:50Z Article http://purl.org/eprint/type/JournalArticle 0960-9822 1879-0445 http://hdl.handle.net/1721.1/112188 Jazayeri, Mehrdad, and Shadlen, Michael N. “A Neural Mechanism for Sensing and Reproducing a Time Interval.” Current Biology 25, 20 (October 2015): 2599–2609 © 2015 Elsevier http://dx.doi.org/10.1016/J.CUB.2015.08.038 Current Biology Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier PMC |
| spellingShingle | Shadlen, Michael N. Jazayeri, Mehrdad A Neural Mechanism for Sensing and Reproducing a Time Interval |
| title | A Neural Mechanism for Sensing and Reproducing a Time Interval |
| title_full | A Neural Mechanism for Sensing and Reproducing a Time Interval |
| title_fullStr | A Neural Mechanism for Sensing and Reproducing a Time Interval |
| title_full_unstemmed | A Neural Mechanism for Sensing and Reproducing a Time Interval |
| title_short | A Neural Mechanism for Sensing and Reproducing a Time Interval |
| title_sort | neural mechanism for sensing and reproducing a time interval |
| url | http://hdl.handle.net/1721.1/112188 |
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