Dicer loss and recovery induce an oncogenic switch driven by transcriptional activation of the oncofetal Imp1–3 family

Dicer loss and recovery induce an oncogenic switch driven by transcriptional activation of the oncofetal Imp1–3 family

MicroRNAs(miRNAs) are post-transcriptional regulators of gene expressioncritical for organismal viability. Changes inmiRNAactivity arecommonin cancer, buthowthese changes relate to subsequent alterations in transcription and the process of tumorigenesis is not well understood. Here, we report a deep...

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Bibliographic Details
Main Authors: JnBaptiste, Courtney Kenneil, Gurtan, Allan, Thai, Kevin K., Lu, Victoria, Bhutkar, Arjun, Jacks, Tyler E., Sharp, Phillip A.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Published: Cold Spring Harbor Laboratory 2017
Online Access:http://hdl.handle.net/1721.1/112212
https://orcid.org/0000-0001-8353-9316
https://orcid.org/0000-0002-2902-7288
https://orcid.org/0000-0001-5785-8911
https://orcid.org/0000-0003-1465-1691

Internet

http://hdl.handle.net/1721.1/112212
https://orcid.org/0000-0001-8353-9316
https://orcid.org/0000-0002-2902-7288
https://orcid.org/0000-0001-5785-8911
https://orcid.org/0000-0003-1465-1691

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