Designing allostery-inspired response in mechanical networks
Recent advances in designing metamaterials have demonstrated that global mechanical properties of disordered spring networks can be tuned by selectively modifying only a small subset of bonds. Here, using a computationally efficient approach, we extend this idea to tune more general properties of ne...
| Main Authors: | , , , , , |
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| Format: | Article |
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National Academy of Sciences (U.S.)
2017
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| Online Access: | http://hdl.handle.net/1721.1/112223 |
| _version_ | 1811069734875037696 |
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| author | Rocks, Jason W. Pashine, Nidhi Bischofberger, Irmgard Goodrich, Carl P. Liu, Andrea J. Nagel, Sidney R. |
| author2 | Massachusetts Institute of Technology. Department of Mechanical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Mechanical Engineering Rocks, Jason W. Pashine, Nidhi Bischofberger, Irmgard Goodrich, Carl P. Liu, Andrea J. Nagel, Sidney R. |
| author_sort | Rocks, Jason W. |
| collection | MIT |
| description | Recent advances in designing metamaterials have demonstrated that global mechanical properties of disordered spring networks can be tuned by selectively modifying only a small subset of bonds. Here, using a computationally efficient approach, we extend this idea to tune more general properties of networks. With nearly complete success, we are able to produce a strain between any two target nodes in a network in response to an applied source strain on any other pair of nodes by removing only ∼1% of the bonds. We are also able to control multiple pairs of target nodes, each with a different individual response, from a single source, and to tune multiple independent source/target responses simultaneously into a network. We have fabricated physical networks in macroscopic 2D and 3D systems that exhibit these responses. This work is inspired by the long-range coupled conformational changes that constitute allosteric function in proteins. The fact that allostery is a common means for regulation in biological molecules suggests that it is a relatively easy property to develop through evolution. In analogy, our results show that long-range coupled mechanical responses are similarly easy to achieve in disordered networks. |
| first_indexed | 2024-09-23T08:15:06Z |
| format | Article |
| id | mit-1721.1/112223 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T08:15:06Z |
| publishDate | 2017 |
| publisher | National Academy of Sciences (U.S.) |
| record_format | dspace |
| spelling | mit-1721.1/1122232022-09-23T11:55:29Z Designing allostery-inspired response in mechanical networks Rocks, Jason W. Pashine, Nidhi Bischofberger, Irmgard Goodrich, Carl P. Liu, Andrea J. Nagel, Sidney R. Massachusetts Institute of Technology. Department of Mechanical Engineering Bischofberger, Irmgard Recent advances in designing metamaterials have demonstrated that global mechanical properties of disordered spring networks can be tuned by selectively modifying only a small subset of bonds. Here, using a computationally efficient approach, we extend this idea to tune more general properties of networks. With nearly complete success, we are able to produce a strain between any two target nodes in a network in response to an applied source strain on any other pair of nodes by removing only ∼1% of the bonds. We are also able to control multiple pairs of target nodes, each with a different individual response, from a single source, and to tune multiple independent source/target responses simultaneously into a network. We have fabricated physical networks in macroscopic 2D and 3D systems that exhibit these responses. This work is inspired by the long-range coupled conformational changes that constitute allosteric function in proteins. The fact that allostery is a common means for regulation in biological molecules suggests that it is a relatively easy property to develop through evolution. In analogy, our results show that long-range coupled mechanical responses are similarly easy to achieve in disordered networks. 2017-11-17T15:58:37Z 2017-11-17T15:58:37Z 2017-02 2016-07 2017-10-30T19:25:56Z Article http://purl.org/eprint/type/JournalArticle 0027-8424 1091-6490 http://hdl.handle.net/1721.1/112223 Rocks, Jason W. et al. “Designing Allostery-Inspired Response in Mechanical Networks.” Proceedings of the National Academy of Sciences 114, 10 (February 2017): 2520–2525 © 2017 National Academy of Sciences http://dx.doi.org/10.1073/pnas.1612139114 Proceedings of the National Academy of Sciences Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf National Academy of Sciences (U.S.) PNAS |
| spellingShingle | Rocks, Jason W. Pashine, Nidhi Bischofberger, Irmgard Goodrich, Carl P. Liu, Andrea J. Nagel, Sidney R. Designing allostery-inspired response in mechanical networks |
| title | Designing allostery-inspired response in mechanical networks |
| title_full | Designing allostery-inspired response in mechanical networks |
| title_fullStr | Designing allostery-inspired response in mechanical networks |
| title_full_unstemmed | Designing allostery-inspired response in mechanical networks |
| title_short | Designing allostery-inspired response in mechanical networks |
| title_sort | designing allostery inspired response in mechanical networks |
| url | http://hdl.handle.net/1721.1/112223 |
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