Gamma frequency entrainment attenuates amyloid load and modifies microglia
Changes in gamma oscillations (20-50 Hz) have been observed in several neurological disorders. However, the relationship between gamma oscillations and cellular pathologies is unclear. Here we show reduced, behaviourally driven gamma oscillations before the onset of plaque formation or cognitive dec...
| প্রধান লেখক: | , , , , , , , , , , , , , , , |
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| অন্যান্য লেখক: | |
| বিন্যাস: | প্রবন্ধ |
| প্রকাশিত: |
Nature Publishing Group
2017
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| অনলাইন ব্যবহার করুন: | http://hdl.handle.net/1721.1/112229 https://orcid.org/0000-0001-8862-2661 https://orcid.org/0000-0003-4111-1535 https://orcid.org/0000-0002-2206-2590 https://orcid.org/0000-0001-5842-5245 https://orcid.org/0000-0002-1332-6902 https://orcid.org/0000-0003-2668-7819 https://orcid.org/0000-0002-0419-3351 https://orcid.org/0000-0003-1262-0592 |
| _version_ | 1826191272403009536 |
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| author | Iaccarino, Hannah Frances Singer, Annabelle Martorell, Anthony Rudenko, Andrii Gao, Fan Gillingham, Tyler Mathys, Hansruedi Seo, Jinsoo Kritskiy, Oleg Abdurrob, Fatema Adaikkan, Chinnakkaruppan Canter, Rebecca Gail Rueda IV, Richard Brown, Emery Neal Boyden, Edward Tsai, Li-Huei |
| author2 | Massachusetts Institute of Technology. Institute for Medical Engineering & Science |
| author_facet | Massachusetts Institute of Technology. Institute for Medical Engineering & Science Iaccarino, Hannah Frances Singer, Annabelle Martorell, Anthony Rudenko, Andrii Gao, Fan Gillingham, Tyler Mathys, Hansruedi Seo, Jinsoo Kritskiy, Oleg Abdurrob, Fatema Adaikkan, Chinnakkaruppan Canter, Rebecca Gail Rueda IV, Richard Brown, Emery Neal Boyden, Edward Tsai, Li-Huei |
| author_sort | Iaccarino, Hannah Frances |
| collection | MIT |
| description | Changes in gamma oscillations (20-50 Hz) have been observed in several neurological disorders. However, the relationship between gamma oscillations and cellular pathologies is unclear. Here we show reduced, behaviourally driven gamma oscillations before the onset of plaque formation or cognitive decline in a mouse model of Alzheimer's disease. Optogenetically driving fast-spiking parvalbumin-positive (FS-PV)-interneurons at gamma (40 Hz), but not other frequencies, reduces levels of amyloid-β (Aβ)[subscript 1-40] and Aβ [subscript 1-42] isoforms. Gene expression profiling revealed induction of genes associated with morphological transformation of microglia, and histological analysis confirmed increased microglia co-localization with Aβ. Subsequently, we designed a non-invasive 40 Hz light-flickering regime that reduced Aβ[subscript 1-40] and Aβ[subscript 1-42] levels in the visual cortex of pre-depositing mice and mitigated plaque load in aged, depositing mice. Our findings uncover a previously unappreciated function of gamma rhythms in recruiting both neuronal and glial responses to attenuate Alzheimer's-disease-associated pathology. |
| first_indexed | 2024-09-23T08:53:39Z |
| format | Article |
| id | mit-1721.1/112229 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T08:53:39Z |
| publishDate | 2017 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | mit-1721.1/1122292024-03-20T19:33:04Z Gamma frequency entrainment attenuates amyloid load and modifies microglia Iaccarino, Hannah Frances Singer, Annabelle Martorell, Anthony Rudenko, Andrii Gao, Fan Gillingham, Tyler Mathys, Hansruedi Seo, Jinsoo Kritskiy, Oleg Abdurrob, Fatema Adaikkan, Chinnakkaruppan Canter, Rebecca Gail Rueda IV, Richard Brown, Emery Neal Boyden, Edward Tsai, Li-Huei Massachusetts Institute of Technology. Institute for Medical Engineering & Science Massachusetts Institute of Technology. Department of Biological Engineering Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Massachusetts Institute of Technology. Media Laboratory McGovern Institute for Brain Research at MIT Picower Institute for Learning and Memory Iaccarino, Hannah Frances Singer, Annabelle Martorell, Anthony Rudenko, Andrii Gao, Fan Gillingham, Tyler Mathys, Hansruedi Seo, Jinsoo Kritskiy, Oleg Abdurrob, Fatema Adaikkan, Chinnakkaruppan Canter, Rebecca Gail Rueda IV, Richard Brown, Emery Neal Boyden, Edward Tsai, Li-Huei Changes in gamma oscillations (20-50 Hz) have been observed in several neurological disorders. However, the relationship between gamma oscillations and cellular pathologies is unclear. Here we show reduced, behaviourally driven gamma oscillations before the onset of plaque formation or cognitive decline in a mouse model of Alzheimer's disease. Optogenetically driving fast-spiking parvalbumin-positive (FS-PV)-interneurons at gamma (40 Hz), but not other frequencies, reduces levels of amyloid-β (Aβ)[subscript 1-40] and Aβ [subscript 1-42] isoforms. Gene expression profiling revealed induction of genes associated with morphological transformation of microglia, and histological analysis confirmed increased microglia co-localization with Aβ. Subsequently, we designed a non-invasive 40 Hz light-flickering regime that reduced Aβ[subscript 1-40] and Aβ[subscript 1-42] levels in the visual cortex of pre-depositing mice and mitigated plaque load in aged, depositing mice. Our findings uncover a previously unappreciated function of gamma rhythms in recruiting both neuronal and glial responses to attenuate Alzheimer's-disease-associated pathology. National Institutes of Health (U.S.) (Grant 1R01EY023173) National Institutes of Health (U.S.) (Grant 1DP1NS087724) National Institutes of Health (U.S.) (Grant RF1AG047661) National Institutes of Health (U.S.) (Grant ROIGM104948) 2017-11-17T20:24:00Z 2017-11-17T20:24:00Z 2016-12 2016-02 2017-11-01T13:17:55Z Article http://purl.org/eprint/type/JournalArticle 0028-0836 1476-4687 http://hdl.handle.net/1721.1/112229 Iaccarino, Hannah F. et al. “Gamma Frequency Entrainment Attenuates Amyloid Load and Modifies Microglia.” Nature 540, 7632 (December 2016): 230–235 © 2016 Macmillan Publishers Limited, part of Springer Nature https://orcid.org/0000-0001-8862-2661 https://orcid.org/0000-0003-4111-1535 https://orcid.org/0000-0002-2206-2590 https://orcid.org/0000-0001-5842-5245 https://orcid.org/0000-0002-1332-6902 https://orcid.org/0000-0003-2668-7819 https://orcid.org/0000-0002-0419-3351 https://orcid.org/0000-0003-1262-0592 http://dx.doi.org/10.1038/NATURE20587 Nature Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Nature Publishing Group PMC |
| spellingShingle | Iaccarino, Hannah Frances Singer, Annabelle Martorell, Anthony Rudenko, Andrii Gao, Fan Gillingham, Tyler Mathys, Hansruedi Seo, Jinsoo Kritskiy, Oleg Abdurrob, Fatema Adaikkan, Chinnakkaruppan Canter, Rebecca Gail Rueda IV, Richard Brown, Emery Neal Boyden, Edward Tsai, Li-Huei Gamma frequency entrainment attenuates amyloid load and modifies microglia |
| title | Gamma frequency entrainment attenuates amyloid load and modifies microglia |
| title_full | Gamma frequency entrainment attenuates amyloid load and modifies microglia |
| title_fullStr | Gamma frequency entrainment attenuates amyloid load and modifies microglia |
| title_full_unstemmed | Gamma frequency entrainment attenuates amyloid load and modifies microglia |
| title_short | Gamma frequency entrainment attenuates amyloid load and modifies microglia |
| title_sort | gamma frequency entrainment attenuates amyloid load and modifies microglia |
| url | http://hdl.handle.net/1721.1/112229 https://orcid.org/0000-0001-8862-2661 https://orcid.org/0000-0003-4111-1535 https://orcid.org/0000-0002-2206-2590 https://orcid.org/0000-0001-5842-5245 https://orcid.org/0000-0002-1332-6902 https://orcid.org/0000-0003-2668-7819 https://orcid.org/0000-0002-0419-3351 https://orcid.org/0000-0003-1262-0592 |
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