GABAA circuit mechanisms are associated with ether anesthesia-induced unconsciousness
Objective: An emerging paradigm for understanding how anesthetics induce altered arousal is relating receptor targeting in specific neural circuits to electroencephalogram (EEG) activity. Enhanced gamma amino-butyric acid A (GABA[subscript A]) inhibitory post-synaptic currents (IPSCs) manifest with...
| Main Authors: | , , , , , |
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| Format: | Article |
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Elsevier
2017
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| Online Access: | http://hdl.handle.net/1721.1/112231 https://orcid.org/0000-0001-9356-9156 https://orcid.org/0000-0001-5651-5060 https://orcid.org/0000-0003-2668-7819 |
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| author | Akeju, Oluwaseun Hamilos, Allison E. Pavone, Kara J. Song, Andrew H. Brown, Emery Neal Purdon, Patrick Lee |
| author2 | Massachusetts Institute of Technology. Institute for Medical Engineering & Science |
| author_facet | Massachusetts Institute of Technology. Institute for Medical Engineering & Science Akeju, Oluwaseun Hamilos, Allison E. Pavone, Kara J. Song, Andrew H. Brown, Emery Neal Purdon, Patrick Lee |
| author_sort | Akeju, Oluwaseun |
| collection | MIT |
| description | Objective: An emerging paradigm for understanding how anesthetics induce altered arousal is relating receptor targeting in specific neural circuits to electroencephalogram (EEG) activity. Enhanced gamma amino-butyric acid A (GABA[subscript A]) inhibitory post-synaptic currents (IPSCs) manifest with large-amplitude slow (0.1-1 Hz) and frontally coherent alpha (8-12 Hz) EEG oscillations during general anesthesia. Therefore, we investigated the EEG signatures of modern day derivatives of ether (MDDE) anesthesia to assess the extent to which we could obtain insights into MDDE anesthetic mechanisms. Methods: We retrospectively studied cases from our database in which patients received isoflurane anesthesia vs. isoflurane/ketamine anesthesia (n = 10 each) or desflurane anesthesia vs. desflurane/ketamine anesthesia (n = 9 each). We analyzed the EEG recordings with spectral power and coherence methods. Results: Similar to known GABA [subscript A] circuit level mechanisms, we found that MDDE anesthesia induced large amplitude slow and frontally coherent alpha oscillations. Additionally, MDDE anesthesia also induced frontally coherent theta (4-8 Hz) oscillations. Reduction of GABAergic IPSCs with ketamine resulted in beta/gamma (13-40 Hz) oscillations, and significantly reduced MDDE anesthesia-induced slow, theta and alpha oscillation power. Conclusions: Large amplitude slow oscillations and coherent alpha and theta oscillations are moderated by ketamine during MDDE anesthesia. Significance: These observations are consistent with the notion that GABA [subscript A] circuit-level mechanisms are associated with MDDE anesthesia-induced unconsciousness. Keywords:
EEG
Isoflurane
Desflurane
Ketamine
Slow oscillations
Alpha oscillations |
| first_indexed | 2024-09-23T10:58:20Z |
| format | Article |
| id | mit-1721.1/112231 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T10:58:20Z |
| publishDate | 2017 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/1122312022-09-27T16:16:35Z GABAA circuit mechanisms are associated with ether anesthesia-induced unconsciousness Akeju, Oluwaseun Hamilos, Allison E. Pavone, Kara J. Song, Andrew H. Brown, Emery Neal Purdon, Patrick Lee Massachusetts Institute of Technology. Institute for Medical Engineering & Science Harvard University--MIT Division of Health Sciences and Technology Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Song, Andrew H. Purdon, Patrick L. Brown, Emery Neal Objective: An emerging paradigm for understanding how anesthetics induce altered arousal is relating receptor targeting in specific neural circuits to electroencephalogram (EEG) activity. Enhanced gamma amino-butyric acid A (GABA[subscript A]) inhibitory post-synaptic currents (IPSCs) manifest with large-amplitude slow (0.1-1 Hz) and frontally coherent alpha (8-12 Hz) EEG oscillations during general anesthesia. Therefore, we investigated the EEG signatures of modern day derivatives of ether (MDDE) anesthesia to assess the extent to which we could obtain insights into MDDE anesthetic mechanisms. Methods: We retrospectively studied cases from our database in which patients received isoflurane anesthesia vs. isoflurane/ketamine anesthesia (n = 10 each) or desflurane anesthesia vs. desflurane/ketamine anesthesia (n = 9 each). We analyzed the EEG recordings with spectral power and coherence methods. Results: Similar to known GABA [subscript A] circuit level mechanisms, we found that MDDE anesthesia induced large amplitude slow and frontally coherent alpha oscillations. Additionally, MDDE anesthesia also induced frontally coherent theta (4-8 Hz) oscillations. Reduction of GABAergic IPSCs with ketamine resulted in beta/gamma (13-40 Hz) oscillations, and significantly reduced MDDE anesthesia-induced slow, theta and alpha oscillation power. Conclusions: Large amplitude slow oscillations and coherent alpha and theta oscillations are moderated by ketamine during MDDE anesthesia. Significance: These observations are consistent with the notion that GABA [subscript A] circuit-level mechanisms are associated with MDDE anesthesia-induced unconsciousness. Keywords: EEG Isoflurane Desflurane Ketamine Slow oscillations Alpha oscillations National Institutes of Health (U.S.) (Grant DP2-OD006454) National Institutes of Health (U.S.) (Grant DP1-OD003646) National Institutes of Health (U.S.) (Grant TR01-GM104948) 2017-11-17T20:43:57Z 2017-11-17T20:43:57Z 2016-02 2017-11-01T13:24:27Z Article http://purl.org/eprint/type/JournalArticle 1388-2457 http://hdl.handle.net/1721.1/112231 Akeju, Oluwaseun, et al. “GABAA Circuit Mechanisms Are Associated with Ether Anesthesia-Induced Unconsciousness.” Clinical Neurophysiology 127, 6 (June 2016): 2472–2481 © 2016 International Federation of Clinical Neurophysiology https://orcid.org/0000-0001-9356-9156 https://orcid.org/0000-0001-5651-5060 https://orcid.org/0000-0003-2668-7819 http://dx.doi.org/10.1016/J.CLINPH.2016.02.012 Clinical Neurophysiology Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier PMC |
| spellingShingle | Akeju, Oluwaseun Hamilos, Allison E. Pavone, Kara J. Song, Andrew H. Brown, Emery Neal Purdon, Patrick Lee GABAA circuit mechanisms are associated with ether anesthesia-induced unconsciousness |
| title | GABAA circuit mechanisms are associated with ether anesthesia-induced unconsciousness |
| title_full | GABAA circuit mechanisms are associated with ether anesthesia-induced unconsciousness |
| title_fullStr | GABAA circuit mechanisms are associated with ether anesthesia-induced unconsciousness |
| title_full_unstemmed | GABAA circuit mechanisms are associated with ether anesthesia-induced unconsciousness |
| title_short | GABAA circuit mechanisms are associated with ether anesthesia-induced unconsciousness |
| title_sort | gabaa circuit mechanisms are associated with ether anesthesia induced unconsciousness |
| url | http://hdl.handle.net/1721.1/112231 https://orcid.org/0000-0001-9356-9156 https://orcid.org/0000-0001-5651-5060 https://orcid.org/0000-0003-2668-7819 |
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