Electroencephalogram signatures of ketamine anesthesia-induced unconsciousness
Objectives: Ketamine is an N-methyl-. d-aspartate (NMDA) receptor antagonist commonly administered as a general anesthetic. However, neural circuit mechanisms to explain ketamine anesthesia-induced unconsciousness in humans are yet to be clearly defined. Disruption of frontal-parietal network connec...
| Main Authors: | , , , , , , |
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Elsevier
2017
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| Online Access: | http://hdl.handle.net/1721.1/112233 https://orcid.org/0000-0001-9356-9156 https://orcid.org/0000-0001-9486-0017 https://orcid.org/0000-0002-8974-9717 https://orcid.org/0000-0001-5651-5060 |
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| author | Akeju, Oluwaseun Pavone, Kara J. Brown, Emery N. Song, Andrew H. Hamilos, Allison E. Flores Plaza, Francisco Javier Purdon, Patrick Lee |
| author2 | Massachusetts Institute of Technology. Institute for Medical Engineering & Science |
| author_facet | Massachusetts Institute of Technology. Institute for Medical Engineering & Science Akeju, Oluwaseun Pavone, Kara J. Brown, Emery N. Song, Andrew H. Hamilos, Allison E. Flores Plaza, Francisco Javier Purdon, Patrick Lee |
| author_sort | Akeju, Oluwaseun |
| collection | MIT |
| description | Objectives: Ketamine is an N-methyl-. d-aspartate (NMDA) receptor antagonist commonly administered as a general anesthetic. However, neural circuit mechanisms to explain ketamine anesthesia-induced unconsciousness in humans are yet to be clearly defined. Disruption of frontal-parietal network connectivity has been proposed as a mechanism to explain this brain state. However, this mechanism was recently demonstrated at subanesthetic doses of ketamine in awake-patients. Therefore, we investigated whether there is an electroencephalogram (EEG) signature specific for ketamine anesthesia-induced unconsciousness. Methods: We retrospectively studied the EEG in 12 patients who received ketamine for the induction of general anesthesia. We analyzed the EEG dynamics using power spectral and coherence methods. Results: Following the administration of a bolus dose of ketamine to induce unconsciousness, we observed a "gamma burst" EEG pattern that consisted of alternating slow-delta (0.1-4 Hz) and gamma (~27-40 Hz) oscillations. This pattern was also associated with increased theta oscillations (~4-8 Hz) and decreased alpha/beta oscillations (~10-24 Hz). Conclusions: Ketamine anesthesia-induced unconsciousness is associated with a gamma burst EEG pattern. Significance: The EEG signature of ketamine anesthesia-induced unconsciousness may offer new insights into NMDA circuit mechanisms for unconsciousness. |
| first_indexed | 2024-09-23T11:05:36Z |
| format | Article |
| id | mit-1721.1/112233 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T11:05:36Z |
| publishDate | 2017 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/1122332022-09-27T17:06:02Z Electroencephalogram signatures of ketamine anesthesia-induced unconsciousness Akeju, Oluwaseun Pavone, Kara J. Brown, Emery N. Song, Andrew H. Hamilos, Allison E. Flores Plaza, Francisco Javier Purdon, Patrick Lee Massachusetts Institute of Technology. Institute for Medical Engineering & Science Harvard University--MIT Division of Health Sciences and Technology Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Song, Andrew H. Hamilos, Allison E. Flores Plaza, Francisco Javier Purdon, Patrick L. Objectives: Ketamine is an N-methyl-. d-aspartate (NMDA) receptor antagonist commonly administered as a general anesthetic. However, neural circuit mechanisms to explain ketamine anesthesia-induced unconsciousness in humans are yet to be clearly defined. Disruption of frontal-parietal network connectivity has been proposed as a mechanism to explain this brain state. However, this mechanism was recently demonstrated at subanesthetic doses of ketamine in awake-patients. Therefore, we investigated whether there is an electroencephalogram (EEG) signature specific for ketamine anesthesia-induced unconsciousness. Methods: We retrospectively studied the EEG in 12 patients who received ketamine for the induction of general anesthesia. We analyzed the EEG dynamics using power spectral and coherence methods. Results: Following the administration of a bolus dose of ketamine to induce unconsciousness, we observed a "gamma burst" EEG pattern that consisted of alternating slow-delta (0.1-4 Hz) and gamma (~27-40 Hz) oscillations. This pattern was also associated with increased theta oscillations (~4-8 Hz) and decreased alpha/beta oscillations (~10-24 Hz). Conclusions: Ketamine anesthesia-induced unconsciousness is associated with a gamma burst EEG pattern. Significance: The EEG signature of ketamine anesthesia-induced unconsciousness may offer new insights into NMDA circuit mechanisms for unconsciousness. National Institutes of Health (U.S.) (Grant DP2-OD006454) 2017-11-20T15:47:05Z 2017-11-20T15:47:05Z 2016-03 2017-11-01T13:28:04Z Article http://purl.org/eprint/type/JournalArticle 1388-2457 http://hdl.handle.net/1721.1/112233 Akeju, Oluwaseun, et al. “Electroencephalogram Signatures of Ketamine Anesthesia-Induced Unconsciousness.” Clinical Neurophysiology 127, 6 (June 2016): 2414–2422 © 2016 International Federation of Clinical Neurophysiology https://orcid.org/0000-0001-9356-9156 https://orcid.org/0000-0001-9486-0017 https://orcid.org/0000-0002-8974-9717 https://orcid.org/0000-0001-5651-5060 http://dx.doi.org/10.1016/J.CLINPH.2016.03.005 Clinical Neurophysiology Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier PMC |
| spellingShingle | Akeju, Oluwaseun Pavone, Kara J. Brown, Emery N. Song, Andrew H. Hamilos, Allison E. Flores Plaza, Francisco Javier Purdon, Patrick Lee Electroencephalogram signatures of ketamine anesthesia-induced unconsciousness |
| title | Electroencephalogram signatures of ketamine anesthesia-induced unconsciousness |
| title_full | Electroencephalogram signatures of ketamine anesthesia-induced unconsciousness |
| title_fullStr | Electroencephalogram signatures of ketamine anesthesia-induced unconsciousness |
| title_full_unstemmed | Electroencephalogram signatures of ketamine anesthesia-induced unconsciousness |
| title_short | Electroencephalogram signatures of ketamine anesthesia-induced unconsciousness |
| title_sort | electroencephalogram signatures of ketamine anesthesia induced unconsciousness |
| url | http://hdl.handle.net/1721.1/112233 https://orcid.org/0000-0001-9356-9156 https://orcid.org/0000-0001-9486-0017 https://orcid.org/0000-0002-8974-9717 https://orcid.org/0000-0001-5651-5060 |
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