Gamma-Rhythmic Gain Modulation
Cognition requires the dynamic modulation of effective connectivity, i.e., the modulation of the postsynaptic neuronal response to a given input. If postsynaptic neurons are rhythmically active, this might entail rhythmic gain modulation, such that inputs synchronized to phases of high gain benefit...
| Main Authors: | , , , , , |
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| Format: | Article |
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Elsevier/Cell Press
2017
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| Online Access: | http://hdl.handle.net/1721.1/112247 https://orcid.org/0000-0002-5938-4227 |
| _version_ | 1826216059368112128 |
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| author | Ni, Jianguang Wunderle, Thomas Lewis, Christopher Murphy Desimone, Robert Diester, Ilka Fries, Pascal |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Ni, Jianguang Wunderle, Thomas Lewis, Christopher Murphy Desimone, Robert Diester, Ilka Fries, Pascal |
| author_sort | Ni, Jianguang |
| collection | MIT |
| description | Cognition requires the dynamic modulation of effective connectivity, i.e., the modulation of the postsynaptic neuronal response to a given input. If postsynaptic neurons are rhythmically active, this might entail rhythmic gain modulation, such that inputs synchronized to phases of high gain benefit from enhanced effective connectivity. We show that visually induced gamma-band activity in awake macaque area V4 rhythmically modulates responses to unpredictable stimulus events. This modulation exceeded a simple additive superposition of a constant response onto ongoing gamma-rhythmic firing, demonstrating the modulation of multiplicative gain. Gamma phases leading to strongest neuronal responses also led to shortest behavioral reaction times, suggesting functional relevance of the effect. Furthermore, we find that constant optogenetic stimulation of anesthetized cat area 21a produces gamma-band activity entailing a similar gain modulation. As the gamma rhythm in area 21a did not spread backward to area 17, this suggests that postsynaptic gamma is sufficient for gain modulation. |
| first_indexed | 2024-09-23T16:41:39Z |
| format | Article |
| id | mit-1721.1/112247 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T16:41:39Z |
| publishDate | 2017 |
| publisher | Elsevier/Cell Press |
| record_format | dspace |
| spelling | mit-1721.1/1122472022-09-29T20:49:30Z Gamma-Rhythmic Gain Modulation Ni, Jianguang Wunderle, Thomas Lewis, Christopher Murphy Desimone, Robert Diester, Ilka Fries, Pascal Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences McGovern Institute for Brain Research at MIT Desimone, Robert Cognition requires the dynamic modulation of effective connectivity, i.e., the modulation of the postsynaptic neuronal response to a given input. If postsynaptic neurons are rhythmically active, this might entail rhythmic gain modulation, such that inputs synchronized to phases of high gain benefit from enhanced effective connectivity. We show that visually induced gamma-band activity in awake macaque area V4 rhythmically modulates responses to unpredictable stimulus events. This modulation exceeded a simple additive superposition of a constant response onto ongoing gamma-rhythmic firing, demonstrating the modulation of multiplicative gain. Gamma phases leading to strongest neuronal responses also led to shortest behavioral reaction times, suggesting functional relevance of the effect. Furthermore, we find that constant optogenetic stimulation of anesthetized cat area 21a produces gamma-band activity entailing a similar gain modulation. As the gamma rhythm in area 21a did not spread backward to area 17, this suggests that postsynaptic gamma is sufficient for gain modulation. 2017-11-20T18:26:57Z 2017-11-20T18:26:57Z 2016-09 2016-08 2017-11-03T11:57:09Z Article http://purl.org/eprint/type/JournalArticle 0896-6273 1097-4199 http://hdl.handle.net/1721.1/112247 Ni, Jianguang et al. “Gamma-Rhythmic Gain Modulation.” Neuron 92, 1 (October 2016): 240–251 © 2016 Elsevier https://orcid.org/0000-0002-5938-4227 http://dx.doi.org/10.1016/J.NEURON.2016.09.003 Neuron Creative Commons Attribution 4.0 International License http://creativecommons.org/licenses/by/4.0/ application/pdf Elsevier/Cell Press Elsevier |
| spellingShingle | Ni, Jianguang Wunderle, Thomas Lewis, Christopher Murphy Desimone, Robert Diester, Ilka Fries, Pascal Gamma-Rhythmic Gain Modulation |
| title | Gamma-Rhythmic Gain Modulation |
| title_full | Gamma-Rhythmic Gain Modulation |
| title_fullStr | Gamma-Rhythmic Gain Modulation |
| title_full_unstemmed | Gamma-Rhythmic Gain Modulation |
| title_short | Gamma-Rhythmic Gain Modulation |
| title_sort | gamma rhythmic gain modulation |
| url | http://hdl.handle.net/1721.1/112247 https://orcid.org/0000-0002-5938-4227 |
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