A Source for Feature-Based Attention in the Prefrontal Cortex
In cluttered scenes, we can use feature-based attention to quickly locate a target object. To understand how feature attention is used to find and select objects for action, we focused on the ventral prearcuate (VPA) region of prefrontal cortex. In a visual search task, VPA cells responded selective...
| Main Authors: | , , , |
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| Format: | Article |
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Elsevier/Cell Press
2017
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| Online Access: | http://hdl.handle.net/1721.1/112248 https://orcid.org/0000-0001-5506-6451 https://orcid.org/0000-0002-5938-4227 |
| _version_ | 1826190256731324416 |
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| author | Bichot, Narcisse Pascal Heard, Matthew Thomas DeGennaro, Ellen Desimone, Robert |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Bichot, Narcisse Pascal Heard, Matthew Thomas DeGennaro, Ellen Desimone, Robert |
| author_sort | Bichot, Narcisse Pascal |
| collection | MIT |
| description | In cluttered scenes, we can use feature-based attention to quickly locate a target object. To understand how feature attention is used to find and select objects for action, we focused on the ventral prearcuate (VPA) region of prefrontal cortex. In a visual search task, VPA cells responded selectively to search cues, maintained their feature selectivity throughout the delay and subsequent saccades, and discriminated the search target in their receptive fields with a time course earlier than in FEF or IT cortex. Inactivation of VPA impaired the animals' ability to find targets, and simultaneous recordings in FEF revealed that the effects of feature attention were eliminated while leaving the effects of spatial attention in FEF intact. Altogether, the results suggest that VPA neurons compute the locations of objects with the features sought and send this information to FEF to guide eye movements to those relevant stimuli. |
| first_indexed | 2024-09-23T08:37:28Z |
| format | Article |
| id | mit-1721.1/112248 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T08:37:28Z |
| publishDate | 2017 |
| publisher | Elsevier/Cell Press |
| record_format | dspace |
| spelling | mit-1721.1/1122482022-09-30T10:05:08Z A Source for Feature-Based Attention in the Prefrontal Cortex Bichot, Narcisse Pascal Heard, Matthew Thomas DeGennaro, Ellen Desimone, Robert Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences McGovern Institute for Brain Research at MIT Bichot, Narcisse Pascal Heard, Matthew Thomas DeGennaro, Ellen Desimone, Robert In cluttered scenes, we can use feature-based attention to quickly locate a target object. To understand how feature attention is used to find and select objects for action, we focused on the ventral prearcuate (VPA) region of prefrontal cortex. In a visual search task, VPA cells responded selectively to search cues, maintained their feature selectivity throughout the delay and subsequent saccades, and discriminated the search target in their receptive fields with a time course earlier than in FEF or IT cortex. Inactivation of VPA impaired the animals' ability to find targets, and simultaneous recordings in FEF revealed that the effects of feature attention were eliminated while leaving the effects of spatial attention in FEF intact. Altogether, the results suggest that VPA neurons compute the locations of objects with the features sought and send this information to FEF to guide eye movements to those relevant stimuli. National Eye Institute (Grant EY017921) National Science Foundation (U.S.) (Grant CCF 1317348) 2017-11-20T18:32:34Z 2017-11-20T18:32:34Z 2015-11 2015-08 2017-11-03T12:14:55Z Article http://purl.org/eprint/type/JournalArticle 0896-6273 1097-4199 http://hdl.handle.net/1721.1/112248 Bichot, Narcisse P. et al. “A Source for Feature-Based Attention in the Prefrontal Cortex.” Neuron 88, 4 (November 2015): 832–844 © 2015 Elsevier https://orcid.org/0000-0001-5506-6451 https://orcid.org/0000-0002-5938-4227 http://dx.doi.org/10.1016/J.NEURON.2015.10.001 Neuron Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier/Cell Press PMC |
| spellingShingle | Bichot, Narcisse Pascal Heard, Matthew Thomas DeGennaro, Ellen Desimone, Robert A Source for Feature-Based Attention in the Prefrontal Cortex |
| title | A Source for Feature-Based Attention in the Prefrontal Cortex |
| title_full | A Source for Feature-Based Attention in the Prefrontal Cortex |
| title_fullStr | A Source for Feature-Based Attention in the Prefrontal Cortex |
| title_full_unstemmed | A Source for Feature-Based Attention in the Prefrontal Cortex |
| title_short | A Source for Feature-Based Attention in the Prefrontal Cortex |
| title_sort | source for feature based attention in the prefrontal cortex |
| url | http://hdl.handle.net/1721.1/112248 https://orcid.org/0000-0001-5506-6451 https://orcid.org/0000-0002-5938-4227 |
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