A role for descending auditory cortical projections in songbird vocal learning
Many learned motor behaviors are acquired by comparing ongoing behavior with an internal representation of correct performance, rather than using an explicit external reward. For example, juvenile songbirds learn to sing by comparing their song with the memory of a tutor song. At present, the brain...
| Main Authors: | , , , |
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| Format: | Article |
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eLife Sciences Publications, Ltd.
2017
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| Online Access: | http://hdl.handle.net/1721.1/112254 https://orcid.org/0000-0001-7539-1745 |
| _version_ | 1826201800440545280 |
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| author | Mandelblat-Cerf, Yael Las, Liora Denissenko, Natalia Fee, Michale Sean |
| author2 | McGovern Institute for Brain Research at MIT |
| author_facet | McGovern Institute for Brain Research at MIT Mandelblat-Cerf, Yael Las, Liora Denissenko, Natalia Fee, Michale Sean |
| author_sort | Mandelblat-Cerf, Yael |
| collection | MIT |
| description | Many learned motor behaviors are acquired by comparing ongoing behavior with an internal representation of correct performance, rather than using an explicit external reward. For example, juvenile songbirds learn to sing by comparing their song with the memory of a tutor song. At present, the brain regions subserving song evaluation are not known. In this study, we report several findings suggesting that song evaluation involves an avian 'cortical' area previously shown to project to the dopaminergic midbrain and other downstream targets. We find that this ventral portion of the intermediate arcopallium (AIV) receives inputs from auditory cortical areas, and that lesions of AIV result in significant deficits in vocal learning. Additionally, AIV neurons exhibit fast responses to disruptive auditory feedback presented during singing, but not during nonsinging periods. Our findings suggest that auditory cortical areas may guide learning by transmitting song evaluation signals to the dopaminergic midbrain and/or other subcortical targets. |
| first_indexed | 2024-09-23T11:57:06Z |
| format | Article |
| id | mit-1721.1/112254 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T11:57:06Z |
| publishDate | 2017 |
| publisher | eLife Sciences Publications, Ltd. |
| record_format | dspace |
| spelling | mit-1721.1/1122542022-09-27T23:04:42Z A role for descending auditory cortical projections in songbird vocal learning Mandelblat-Cerf, Yael Las, Liora Denissenko, Natalia Fee, Michale Sean McGovern Institute for Brain Research at MIT Mandelblat-Cerf, Yael Las, Liora Denissenko, Natalia Fee, Michale Sean Many learned motor behaviors are acquired by comparing ongoing behavior with an internal representation of correct performance, rather than using an explicit external reward. For example, juvenile songbirds learn to sing by comparing their song with the memory of a tutor song. At present, the brain regions subserving song evaluation are not known. In this study, we report several findings suggesting that song evaluation involves an avian 'cortical' area previously shown to project to the dopaminergic midbrain and other downstream targets. We find that this ventral portion of the intermediate arcopallium (AIV) receives inputs from auditory cortical areas, and that lesions of AIV result in significant deficits in vocal learning. Additionally, AIV neurons exhibit fast responses to disruptive auditory feedback presented during singing, but not during nonsinging periods. Our findings suggest that auditory cortical areas may guide learning by transmitting song evaluation signals to the dopaminergic midbrain and/or other subcortical targets. National Institutes of Health (U.S.) (Grant R01 MH067105) 2017-11-20T20:10:46Z 2017-11-20T20:10:46Z 2014-06 2013-12 2017-11-03T16:16:24Z Article http://purl.org/eprint/type/JournalArticle 2050-084X http://hdl.handle.net/1721.1/112254 Mandelblat-Cerf et al. “A role for descending auditory cortical projections in songbird vocal learning” eLife 2014, 3(June 2014): e02152 © 2014 Mandelblat-Cerf et al https://orcid.org/0000-0001-7539-1745 http://dx.doi.org/10.7554/eLife.02152.001 eLife Creative Commons Attribution 4.0 International License http://creativecommons.org/licenses/by/4.0/ application/pdf eLife Sciences Publications, Ltd. eLife |
| spellingShingle | Mandelblat-Cerf, Yael Las, Liora Denissenko, Natalia Fee, Michale Sean A role for descending auditory cortical projections in songbird vocal learning |
| title | A role for descending auditory cortical projections in songbird vocal learning |
| title_full | A role for descending auditory cortical projections in songbird vocal learning |
| title_fullStr | A role for descending auditory cortical projections in songbird vocal learning |
| title_full_unstemmed | A role for descending auditory cortical projections in songbird vocal learning |
| title_short | A role for descending auditory cortical projections in songbird vocal learning |
| title_sort | role for descending auditory cortical projections in songbird vocal learning |
| url | http://hdl.handle.net/1721.1/112254 https://orcid.org/0000-0001-7539-1745 |
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