Structural basis for the role of inhibition in facilitating adult brain plasticity
Although inhibition has been implicated in mediating plasticity in the adult brain, the underlying mechanism remains unclear. Here we present a structural mechanism for the role of inhibition in experience-dependent plasticity. Using chronic in vivo two-photon microscopy in the mouse neocortex, we s...
| Main Authors: | , , , , , |
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| Format: | Article |
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Nature Publishing Group
2017
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| Online Access: | http://hdl.handle.net/1721.1/112280 https://orcid.org/0000-0003-4698-6488 https://orcid.org/0000-0002-1710-0767 |
| _version_ | 1811083361458847744 |
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| author | Kubota, Yoshiyuki Lin, Walter C Cha, Jae Won So, Peter T. C. Nedivi, Elly Chen, Jerry L. |
| author2 | Harvard University--MIT Division of Health Sciences and Technology |
| author_facet | Harvard University--MIT Division of Health Sciences and Technology Kubota, Yoshiyuki Lin, Walter C Cha, Jae Won So, Peter T. C. Nedivi, Elly Chen, Jerry L. |
| author_sort | Kubota, Yoshiyuki |
| collection | MIT |
| description | Although inhibition has been implicated in mediating plasticity in the adult brain, the underlying mechanism remains unclear. Here we present a structural mechanism for the role of inhibition in experience-dependent plasticity. Using chronic in vivo two-photon microscopy in the mouse neocortex, we show that experience drives structural remodeling of superficial layer 2/3 interneurons in an input- and circuit-specific manner, with up to 16% of branch tips undergoing remodeling. Visual deprivation initially induces dendritic branch retractions, and this is accompanied by a loss of inhibitory inputs onto neighboring pyramidal cells. The resulting decrease in inhibitory tone, also achievable pharmacologically using the antidepressant fluoxetine, provides a permissive environment for further structural adaptation, including addition of new synapse-bearing branch tips. Our findings suggest that therapeutic approaches that reduce inhibition, when combined with an instructive stimulus, could facilitate restructuring of mature circuits impaired by damage or disease, improving function and perhaps enhancing cognitive abilities. |
| first_indexed | 2024-09-23T12:31:50Z |
| format | Article |
| id | mit-1721.1/112280 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T12:31:50Z |
| publishDate | 2017 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | mit-1721.1/1122802022-10-01T09:35:35Z Structural basis for the role of inhibition in facilitating adult brain plasticity Kubota, Yoshiyuki Lin, Walter C Cha, Jae Won So, Peter T. C. Nedivi, Elly Chen, Jerry L. Harvard University--MIT Division of Health Sciences and Technology Massachusetts Institute of Technology. Department of Biological Engineering Massachusetts Institute of Technology. Department of Biology Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Massachusetts Institute of Technology. Department of Mechanical Engineering Picower Institute for Learning and Memory Chen, Jerry L Lin, Walter C Cha, Jae Won So, Peter T. C. Nedivi, Elly Although inhibition has been implicated in mediating plasticity in the adult brain, the underlying mechanism remains unclear. Here we present a structural mechanism for the role of inhibition in experience-dependent plasticity. Using chronic in vivo two-photon microscopy in the mouse neocortex, we show that experience drives structural remodeling of superficial layer 2/3 interneurons in an input- and circuit-specific manner, with up to 16% of branch tips undergoing remodeling. Visual deprivation initially induces dendritic branch retractions, and this is accompanied by a loss of inhibitory inputs onto neighboring pyramidal cells. The resulting decrease in inhibitory tone, also achievable pharmacologically using the antidepressant fluoxetine, provides a permissive environment for further structural adaptation, including addition of new synapse-bearing branch tips. Our findings suggest that therapeutic approaches that reduce inhibition, when combined with an instructive stimulus, could facilitate restructuring of mature circuits impaired by damage or disease, improving function and perhaps enhancing cognitive abilities. 2017-11-22T16:17:58Z 2017-11-22T16:17:58Z 2011-04 2010-11 2017-11-16T18:14:13Z Article http://purl.org/eprint/type/JournalArticle 1097-6256 1546-1726 http://hdl.handle.net/1721.1/112280 Chen, Jerry L et al. “Structural Basis for the Role of Inhibition in Facilitating Adult Brain Plasticity.” Nature Neuroscience 14, 5 (April 2011): 587–594 © 2011 Nature America, Inc https://orcid.org/0000-0003-4698-6488 https://orcid.org/0000-0002-1710-0767 http://dx.doi.org/10.1038/nn.2799 Nature Neuroscience Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Nature Publishing Group PMC |
| spellingShingle | Kubota, Yoshiyuki Lin, Walter C Cha, Jae Won So, Peter T. C. Nedivi, Elly Chen, Jerry L. Structural basis for the role of inhibition in facilitating adult brain plasticity |
| title | Structural basis for the role of inhibition in facilitating adult brain plasticity |
| title_full | Structural basis for the role of inhibition in facilitating adult brain plasticity |
| title_fullStr | Structural basis for the role of inhibition in facilitating adult brain plasticity |
| title_full_unstemmed | Structural basis for the role of inhibition in facilitating adult brain plasticity |
| title_short | Structural basis for the role of inhibition in facilitating adult brain plasticity |
| title_sort | structural basis for the role of inhibition in facilitating adult brain plasticity |
| url | http://hdl.handle.net/1721.1/112280 https://orcid.org/0000-0003-4698-6488 https://orcid.org/0000-0002-1710-0767 |
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