Zika virus evolution and spread in the Americas
Although the recent Zika virus (ZIKV) epidemic in the Americas and its link to birth defects have attracted a great deal of attention1,2, much remains unknown about ZIKV disease epidemiology and ZIKV evolution, in part owing to a lack of genomic data. Here we address this gap in knowledge by using m...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | en_US |
| Published: |
Nature Publishing Group
2017
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| Online Access: | http://hdl.handle.net/1721.1/112338 https://orcid.org/0000-0002-8871-2349 https://orcid.org/0000-0003-2570-9588 https://orcid.org/0000-0002-9387-8212 |
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| author | Matranga, Christian B. Wohl, Shirlee Freije, Catherine A. Winnicki, Sarah M. West, Kendra Baniecki, Mary Lynn Gladden-Young, Adrianne Lin, Aaron E. Tomkins-Tinch, Christopher H. Luo, Cynthia Y. Shah, Rickey R. Chak, Bridget Barbosa-Lima, Giselle Delatorre, Edson Vieira, Yasmine R. Paul, Lauren M. Tan, Amanda L. Barcellona, Carolyn M. Porcelli, Mario C. Vasquez, Chalmers Cannons, Andrew C. Cone, Marshall R. Hogan, Kelly N. Kopp, Edgar W. Anzinger, Joshua J. Garcia, Kimberly F. Parham, Leda A. Ramírez, Rosa M. Gélvez Montoya, Maria C. Miranda Rojas, Diana P. Brown, Catherine M. Hennigan, Scott Sabina, Brandon Scotland, Sarah Gangavarapu, Karthik Grubaugh, Nathan D. Oliveira, Glenn Robles-Sikisaka, Refugio Rambaut, Andrew Smole, Sandra Halloran, M. Elizabeth Villar, Luis Mattar, Salim Lorenzana, Ivette Cerbino-Neto, Jose Valim, Clarissa Degrave, Wim Bozza, Patricia T. Isern, Sharon Michael, Scott F. Bozza, Fernando A. Souza, Thiago M. L. Yozwiak, Nathan L. MacInnis, Bronwyn L. Sabeti, Pardis C. Metsky, Hayden C. Schaffner, Stephen F Quigley, James Edwin Ye, Simon Huang Park, Daniel Barnes, Kayla Gehrke, Lee Gnirke, Andreas Andersen, Kristian Bosch, Irene |
| author2 | Institute for Medical Engineering and Science |
| author_facet | Institute for Medical Engineering and Science Matranga, Christian B. Wohl, Shirlee Freije, Catherine A. Winnicki, Sarah M. West, Kendra Baniecki, Mary Lynn Gladden-Young, Adrianne Lin, Aaron E. Tomkins-Tinch, Christopher H. Luo, Cynthia Y. Shah, Rickey R. Chak, Bridget Barbosa-Lima, Giselle Delatorre, Edson Vieira, Yasmine R. Paul, Lauren M. Tan, Amanda L. Barcellona, Carolyn M. Porcelli, Mario C. Vasquez, Chalmers Cannons, Andrew C. Cone, Marshall R. Hogan, Kelly N. Kopp, Edgar W. Anzinger, Joshua J. Garcia, Kimberly F. Parham, Leda A. Ramírez, Rosa M. Gélvez Montoya, Maria C. Miranda Rojas, Diana P. Brown, Catherine M. Hennigan, Scott Sabina, Brandon Scotland, Sarah Gangavarapu, Karthik Grubaugh, Nathan D. Oliveira, Glenn Robles-Sikisaka, Refugio Rambaut, Andrew Smole, Sandra Halloran, M. Elizabeth Villar, Luis Mattar, Salim Lorenzana, Ivette Cerbino-Neto, Jose Valim, Clarissa Degrave, Wim Bozza, Patricia T. Isern, Sharon Michael, Scott F. Bozza, Fernando A. Souza, Thiago M. L. Yozwiak, Nathan L. MacInnis, Bronwyn L. Sabeti, Pardis C. Metsky, Hayden C. Schaffner, Stephen F Quigley, James Edwin Ye, Simon Huang Park, Daniel Barnes, Kayla Gehrke, Lee Gnirke, Andreas Andersen, Kristian Bosch, Irene |
| author_sort | Matranga, Christian B. |
| collection | MIT |
| description | Although the recent Zika virus (ZIKV) epidemic in the Americas and its link to birth defects have attracted a great deal of attention1,2, much remains unknown about ZIKV disease epidemiology and ZIKV evolution, in part owing to a lack of genomic data. Here we address this gap in knowledge by using multiple sequencing approaches to generate 110 ZIKV genomes from clinical and mosquito samples from 10 countries and territories, greatly expanding the observed viral genetic diversity from this outbreak. We analysed the timing and patterns of introductions into distinct geographic regions; our phylogenetic evidence suggests rapid expansion of the outbreak in Brazil and multiple introductions of outbreak strains into Puerto Rico, Honduras, Colombia, other Caribbean islands, and the continental United States. We find that ZIKV circulated undetected in multiple regions for many months before the first locally transmitted cases were confirmed, highlighting the importance of surveillance of viral infections. We identify mutations with possible functional implications for ZIKV biology and pathogenesis, as well as those that might be relevant to the effectiveness of diagnostic tests. |
| first_indexed | 2024-09-23T14:21:42Z |
| format | Article |
| id | mit-1721.1/112338 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T14:21:42Z |
| publishDate | 2017 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | mit-1721.1/1123382022-10-01T20:50:23Z Zika virus evolution and spread in the Americas Matranga, Christian B. Wohl, Shirlee Freije, Catherine A. Winnicki, Sarah M. West, Kendra Baniecki, Mary Lynn Gladden-Young, Adrianne Lin, Aaron E. Tomkins-Tinch, Christopher H. Luo, Cynthia Y. Shah, Rickey R. Chak, Bridget Barbosa-Lima, Giselle Delatorre, Edson Vieira, Yasmine R. Paul, Lauren M. Tan, Amanda L. Barcellona, Carolyn M. Porcelli, Mario C. Vasquez, Chalmers Cannons, Andrew C. Cone, Marshall R. Hogan, Kelly N. Kopp, Edgar W. Anzinger, Joshua J. Garcia, Kimberly F. Parham, Leda A. Ramírez, Rosa M. Gélvez Montoya, Maria C. Miranda Rojas, Diana P. Brown, Catherine M. Hennigan, Scott Sabina, Brandon Scotland, Sarah Gangavarapu, Karthik Grubaugh, Nathan D. Oliveira, Glenn Robles-Sikisaka, Refugio Rambaut, Andrew Smole, Sandra Halloran, M. Elizabeth Villar, Luis Mattar, Salim Lorenzana, Ivette Cerbino-Neto, Jose Valim, Clarissa Degrave, Wim Bozza, Patricia T. Isern, Sharon Michael, Scott F. Bozza, Fernando A. Souza, Thiago M. L. Yozwiak, Nathan L. MacInnis, Bronwyn L. Sabeti, Pardis C. Metsky, Hayden C. Schaffner, Stephen F Quigley, James Edwin Ye, Simon Huang Park, Daniel Barnes, Kayla Gehrke, Lee Gnirke, Andreas Andersen, Kristian Bosch, Irene Institute for Medical Engineering and Science Broad Institute of MIT and Harvard Harvard University--MIT Division of Health Sciences and Technology Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Metsky, Hayden C. Metsky, Hayden C. Schaffner, Stephen F Quigley, James Edwin Ye, Simon Huang Park, Daniel Barnes, Kayla Gehrke, Lee Valim, Clarissa Gnirke, Andreas Andersen, Kristian Bosch, Irene Although the recent Zika virus (ZIKV) epidemic in the Americas and its link to birth defects have attracted a great deal of attention1,2, much remains unknown about ZIKV disease epidemiology and ZIKV evolution, in part owing to a lack of genomic data. Here we address this gap in knowledge by using multiple sequencing approaches to generate 110 ZIKV genomes from clinical and mosquito samples from 10 countries and territories, greatly expanding the observed viral genetic diversity from this outbreak. We analysed the timing and patterns of introductions into distinct geographic regions; our phylogenetic evidence suggests rapid expansion of the outbreak in Brazil and multiple introductions of outbreak strains into Puerto Rico, Honduras, Colombia, other Caribbean islands, and the continental United States. We find that ZIKV circulated undetected in multiple regions for many months before the first locally transmitted cases were confirmed, highlighting the importance of surveillance of viral infections. We identify mutations with possible functional implications for ZIKV biology and pathogenesis, as well as those that might be relevant to the effectiveness of diagnostic tests. National Institutes of Health (U.S.) (Grant NIAID U19AI110818) 2017-12-01T16:28:31Z 2017-12-01T16:28:31Z 2017-05 2017-03 Article http://purl.org/eprint/type/JournalArticle 0028-0836 1476-4687 http://hdl.handle.net/1721.1/112338 Metsky, Hayden C. et al. “Zika Virus Evolution and Spread in the Americas.” Nature 546, 7658 (May 2017): 411–415 © 2017 Macmillan Publishers Limited, part of Springer Nature https://orcid.org/0000-0002-8871-2349 https://orcid.org/0000-0003-2570-9588 https://orcid.org/0000-0002-9387-8212 en_US http://dx.doi.org/doi:10.1038/nature22402 Nature Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Nature Publishing Group Metsky |
| spellingShingle | Matranga, Christian B. Wohl, Shirlee Freije, Catherine A. Winnicki, Sarah M. West, Kendra Baniecki, Mary Lynn Gladden-Young, Adrianne Lin, Aaron E. Tomkins-Tinch, Christopher H. Luo, Cynthia Y. Shah, Rickey R. Chak, Bridget Barbosa-Lima, Giselle Delatorre, Edson Vieira, Yasmine R. Paul, Lauren M. Tan, Amanda L. Barcellona, Carolyn M. Porcelli, Mario C. Vasquez, Chalmers Cannons, Andrew C. Cone, Marshall R. Hogan, Kelly N. Kopp, Edgar W. Anzinger, Joshua J. Garcia, Kimberly F. Parham, Leda A. Ramírez, Rosa M. Gélvez Montoya, Maria C. Miranda Rojas, Diana P. Brown, Catherine M. Hennigan, Scott Sabina, Brandon Scotland, Sarah Gangavarapu, Karthik Grubaugh, Nathan D. Oliveira, Glenn Robles-Sikisaka, Refugio Rambaut, Andrew Smole, Sandra Halloran, M. Elizabeth Villar, Luis Mattar, Salim Lorenzana, Ivette Cerbino-Neto, Jose Valim, Clarissa Degrave, Wim Bozza, Patricia T. Isern, Sharon Michael, Scott F. Bozza, Fernando A. Souza, Thiago M. L. Yozwiak, Nathan L. MacInnis, Bronwyn L. Sabeti, Pardis C. Metsky, Hayden C. Schaffner, Stephen F Quigley, James Edwin Ye, Simon Huang Park, Daniel Barnes, Kayla Gehrke, Lee Gnirke, Andreas Andersen, Kristian Bosch, Irene Zika virus evolution and spread in the Americas |
| title | Zika virus evolution and spread in the Americas |
| title_full | Zika virus evolution and spread in the Americas |
| title_fullStr | Zika virus evolution and spread in the Americas |
| title_full_unstemmed | Zika virus evolution and spread in the Americas |
| title_short | Zika virus evolution and spread in the Americas |
| title_sort | zika virus evolution and spread in the americas |
| url | http://hdl.handle.net/1721.1/112338 https://orcid.org/0000-0002-8871-2349 https://orcid.org/0000-0003-2570-9588 https://orcid.org/0000-0002-9387-8212 |
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