Flow-IEG enables programmable thermodynamic properties in sequence-defined unimolecular macromolecules
Thesis: S.M., Massachusetts Institute of Technology, Department of Chemistry, 2017.
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| Format: | Thesis |
| Language: | eng |
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Massachusetts Institute of Technology
2017
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| Online Access: | http://hdl.handle.net/1721.1/112450 |
| _version_ | 1826201902448115712 |
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| author | Wicker, Amanda C. (Amanda Catherine) |
| author2 | Timothy F. Jamison. |
| author_facet | Timothy F. Jamison. Wicker, Amanda C. (Amanda Catherine) |
| author_sort | Wicker, Amanda C. (Amanda Catherine) |
| collection | MIT |
| description | Thesis: S.M., Massachusetts Institute of Technology, Department of Chemistry, 2017. |
| first_indexed | 2024-09-23T11:58:40Z |
| format | Thesis |
| id | mit-1721.1/112450 |
| institution | Massachusetts Institute of Technology |
| language | eng |
| last_indexed | 2024-09-23T11:58:40Z |
| publishDate | 2017 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/1124502019-04-12T23:12:33Z Flow-IEG enables programmable thermodynamic properties in sequence-defined unimolecular macromolecules Wicker, Amanda C. (Amanda Catherine) Timothy F. Jamison. Massachusetts Institute of Technology. Department of Chemistry. Massachusetts Institute of Technology. Department of Chemistry. Chemistry. Thesis: S.M., Massachusetts Institute of Technology, Department of Chemistry, 2017. Cataloged from PDF version of thesis. Includes bibliographical references (pages 40-42). Flow-IEG has emerged as a powerful platform for the production of sequence-defined macromolecules and has demonstrated the utility of adapting continuous-flow methodologies to the production of materials for structure/function analysis. Our Flow-IEG system has been expanded to include both the ruthenium-catalyzed azide-alkyne cycloaddition (RuAAC), as well as a more operationally simple version of the copper-catalyzed analogue (CuAAC). These advances have enabled the rapid synthesis of a library of oligomers with systematic variations in triazole connectivity, allowing us to probe the consequences of sequential connectivity on material properties. In our investigation, we found that the crystallinity of the synthesized materials increased with higher proportions of 1,4- to 1,5-triazoles, from which a set of predictive design rules was developed and applied to a second library of diblock copolymers. Furthermore, we discovered that the crystallization properties of these macromolecules were highly dependent on both their monomer sequence and triazole substitution pattern. The results of these studies are reported herein. by Amanda C. Wicker. S.M. 2017-12-05T19:13:22Z 2017-12-05T19:13:22Z 2017 2017 Thesis http://hdl.handle.net/1721.1/112450 1008968980 eng MIT theses are protected by copyright. They may be viewed, downloaded, or printed from this source but further reproduction or distribution in any format is prohibited without written permission. http://dspace.mit.edu/handle/1721.1/7582 86 pages application/pdf Massachusetts Institute of Technology |
| spellingShingle | Chemistry. Wicker, Amanda C. (Amanda Catherine) Flow-IEG enables programmable thermodynamic properties in sequence-defined unimolecular macromolecules |
| title | Flow-IEG enables programmable thermodynamic properties in sequence-defined unimolecular macromolecules |
| title_full | Flow-IEG enables programmable thermodynamic properties in sequence-defined unimolecular macromolecules |
| title_fullStr | Flow-IEG enables programmable thermodynamic properties in sequence-defined unimolecular macromolecules |
| title_full_unstemmed | Flow-IEG enables programmable thermodynamic properties in sequence-defined unimolecular macromolecules |
| title_short | Flow-IEG enables programmable thermodynamic properties in sequence-defined unimolecular macromolecules |
| title_sort | flow ieg enables programmable thermodynamic properties in sequence defined unimolecular macromolecules |
| topic | Chemistry. |
| url | http://hdl.handle.net/1721.1/112450 |
| work_keys_str_mv | AT wickeramandacamandacatherine flowiegenablesprogrammablethermodynamicpropertiesinsequencedefinedunimolecularmacromolecules |