Neuron-glia networks: integral gear of brain function
Astrocytes, the most abundant glial cell in the brain, play critical roles in metabolic and homeostatic functions of the Nervous System; however, their participation in coding information and cognitive processes has been largely ignored. The strategic position of astrocyte processes facing synapses...
| Main Authors: | , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Published: |
Frontiers Research Foundation
2017
|
| Online Access: | http://hdl.handle.net/1721.1/112612 https://orcid.org/0000-0003-2442-5671 |
| _version_ | 1826213743151808512 |
|---|---|
| author | Perea, Gertrudis Araque, Alfonso Sur, Mriganka |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Perea, Gertrudis Araque, Alfonso Sur, Mriganka |
| author_sort | Perea, Gertrudis |
| collection | MIT |
| description | Astrocytes, the most abundant glial cell in the brain, play critical roles in metabolic and homeostatic functions of the Nervous System; however, their participation in coding information and cognitive processes has been largely ignored. The strategic position of astrocyte processes facing synapses and the astrocyte ability to uptake neurotransmitters and release neuroactive substances, so-called “gliotransmitters”, provide the scenario for prolific neuron-astrocyte signaling. From studies at single-cell level to animal behavior, recent advances in technology and genetics have revealed the impact of astrocyte activity in brain function from cellular and synaptic physiology, neuronal circuits to behavior. The present review critically discusses the consequences of astrocyte signaling on synapses and networks, as well as its impact on neuronal information processing, showing that some crucial brain functions arise from the coordinated activity of neuron-glia networks. |
| first_indexed | 2024-09-23T15:54:06Z |
| format | Article |
| id | mit-1721.1/112612 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T15:54:06Z |
| publishDate | 2017 |
| publisher | Frontiers Research Foundation |
| record_format | dspace |
| spelling | mit-1721.1/1126122022-09-29T16:57:25Z Neuron-glia networks: integral gear of brain function Perea, Gertrudis Araque, Alfonso Sur, Mriganka Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Picower Institute for Learning and Memory Sur, Mriganka Astrocytes, the most abundant glial cell in the brain, play critical roles in metabolic and homeostatic functions of the Nervous System; however, their participation in coding information and cognitive processes has been largely ignored. The strategic position of astrocyte processes facing synapses and the astrocyte ability to uptake neurotransmitters and release neuroactive substances, so-called “gliotransmitters”, provide the scenario for prolific neuron-astrocyte signaling. From studies at single-cell level to animal behavior, recent advances in technology and genetics have revealed the impact of astrocyte activity in brain function from cellular and synaptic physiology, neuronal circuits to behavior. The present review critically discusses the consequences of astrocyte signaling on synapses and networks, as well as its impact on neuronal information processing, showing that some crucial brain functions arise from the coordinated activity of neuron-glia networks. National Institutes of Health (U.S.) (Grant EY007023) National Science Foundation (U.S.) (Award 1010363) 2017-12-05T19:50:09Z 2017-12-05T19:50:09Z 2014-11 2014-09 2017-12-05T19:00:08Z Article http://purl.org/eprint/type/JournalArticle 1662-5102 http://hdl.handle.net/1721.1/112612 Perea, Gertrudis et al. "Neuron-glia networks: integral gear of brain function." Frontiers in Cellular Neuroscience, 8 (November 2014): 378 © 2014 Perea, Sur and Araque https://orcid.org/0000-0003-2442-5671 http://dx.doi.org/10.3389/fncel.2014.00378 Frontiers in Cellular Neuroscience Creative Commons Attribution 4.0 International License http://creativecommons.org/licenses/by/4.0/ application/pdf Frontiers Research Foundation Frontiers |
| spellingShingle | Perea, Gertrudis Araque, Alfonso Sur, Mriganka Neuron-glia networks: integral gear of brain function |
| title | Neuron-glia networks: integral gear of brain function |
| title_full | Neuron-glia networks: integral gear of brain function |
| title_fullStr | Neuron-glia networks: integral gear of brain function |
| title_full_unstemmed | Neuron-glia networks: integral gear of brain function |
| title_short | Neuron-glia networks: integral gear of brain function |
| title_sort | neuron glia networks integral gear of brain function |
| url | http://hdl.handle.net/1721.1/112612 https://orcid.org/0000-0003-2442-5671 |
| work_keys_str_mv | AT pereagertrudis neuronglianetworksintegralgearofbrainfunction AT araquealfonso neuronglianetworksintegralgearofbrainfunction AT surmriganka neuronglianetworksintegralgearofbrainfunction |