The Transcription Factor Sp3 Cooperates with HDAC2 to Regulate Synaptic Function and Plasticity in Neurons
The histone deacetylase HDAC2, which negatively regulates synaptic gene expression and neuronal plasticity, is upregulated in Alzheimer's disease (AD) patients and mouse models. Therapeutics targeting HDAC2 hold promise for ameliorating AD-related cognitive impairment; however, attempts to gene...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
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Elsevier
2017
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| Online Access: | http://hdl.handle.net/1721.1/112678 https://orcid.org/0000-0003-4000-8827 https://orcid.org/0000-0001-5607-113X https://orcid.org/0000-0002-0591-5993 https://orcid.org/0000-0002-3255-4740 https://orcid.org/0000-0003-1262-0592 |