An engineered protein antagonist of K-Ras/B-Raf interaction

An engineered protein antagonist of K-Ras/B-Raf interaction

Ras is at the hub of signal transduction pathways controlling cell proliferation and survival. Its mutants, present in about 30% of human cancers, are major drivers of oncogenesis and render tumors unresponsive to standard therapies. Here we report the engineering of a protein scaffold for preferent...

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Bibliographic Details
Main Authors: Parker, Jillian A., Kiefer, Jonathan D., Knihtila, Ryan, McGee, John, Verdine, Greg, Mattos, Carla, Kauke, Monique Jacqueline, Traxlmayr, Michael, Wittrup, Karl Dane
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Published: Nature Publishing Group 2017
Online Access:http://hdl.handle.net/1721.1/112691
https://orcid.org/0000-0002-0013-3941
https://orcid.org/0000-0002-2108-582X
https://orcid.org/0000-0003-2398-5896

Internet

http://hdl.handle.net/1721.1/112691
https://orcid.org/0000-0002-0013-3941
https://orcid.org/0000-0002-2108-582X
https://orcid.org/0000-0003-2398-5896

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