An engineered protein antagonist of K-Ras/B-Raf interaction
Ras is at the hub of signal transduction pathways controlling cell proliferation and survival. Its mutants, present in about 30% of human cancers, are major drivers of oncogenesis and render tumors unresponsive to standard therapies. Here we report the engineering of a protein scaffold for preferent...
| Main Authors: | , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
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Nature Publishing Group
2017
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| Online Access: | http://hdl.handle.net/1721.1/112691 https://orcid.org/0000-0002-0013-3941 https://orcid.org/0000-0002-2108-582X https://orcid.org/0000-0003-2398-5896 |