DNA Damage and Its Links to Neurodegeneration
The integrity of our genetic material is under constant attack from numerous endogenous and exogenous agents. The consequences of a defective DNA damage response are well studied in proliferating cells, especially with regards to the development of cancer, yet its precise roles in the nervous system...
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| Format: | Article |
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Elsevier/Cell Press
2017
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| Online Access: | http://hdl.handle.net/1721.1/112701 https://orcid.org/0000-0001-9947-9071 https://orcid.org/0000-0003-1262-0592 |
| _version_ | 1826202167228235776 |
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| author | Madabhushi, Ram Pan, Ling Tsai, Li-Huei |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Madabhushi, Ram Pan, Ling Tsai, Li-Huei |
| author_sort | Madabhushi, Ram |
| collection | MIT |
| description | The integrity of our genetic material is under constant attack from numerous endogenous and exogenous agents. The consequences of a defective DNA damage response are well studied in proliferating cells, especially with regards to the development of cancer, yet its precise roles in the nervous system are relatively poorly understood. Here we attempt to provide a comprehensive overview of the consequences of genomic instability in the nervous system. We highlight the neuropathology of congenital syndromes that result from mutations in DNA repair factors and underscore the importance of the DNA damage response in neural development. In addition, we describe the findings of recent studies, which reveal that a robust DNA damage response is also intimately connected to aging and the manifestation of age-related neurodegenerative disorders such as Alzheimer's disease and amyotrophic lateral sclerosis. Video Abstract: In this Review, Madabhushi etal. summarize the current state of knowledge about how DNA damage and changes to the DNA damage response in neurons might underlie neurodegenerative diseases. |
| first_indexed | 2024-09-23T12:03:15Z |
| format | Article |
| id | mit-1721.1/112701 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T12:03:15Z |
| publishDate | 2017 |
| publisher | Elsevier/Cell Press |
| record_format | dspace |
| spelling | mit-1721.1/1127012022-09-27T23:46:28Z DNA Damage and Its Links to Neurodegeneration Madabhushi, Ram Pan, Ling Tsai, Li-Huei Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Picower Institute for Learning and Memory Madabhushi, Ram Pan, Ling Tsai, Li-Huei The integrity of our genetic material is under constant attack from numerous endogenous and exogenous agents. The consequences of a defective DNA damage response are well studied in proliferating cells, especially with regards to the development of cancer, yet its precise roles in the nervous system are relatively poorly understood. Here we attempt to provide a comprehensive overview of the consequences of genomic instability in the nervous system. We highlight the neuropathology of congenital syndromes that result from mutations in DNA repair factors and underscore the importance of the DNA damage response in neural development. In addition, we describe the findings of recent studies, which reveal that a robust DNA damage response is also intimately connected to aging and the manifestation of age-related neurodegenerative disorders such as Alzheimer's disease and amyotrophic lateral sclerosis. Video Abstract: In this Review, Madabhushi etal. summarize the current state of knowledge about how DNA damage and changes to the DNA damage response in neurons might underlie neurodegenerative diseases. 2017-12-12T14:39:01Z 2017-12-12T14:39:01Z 2014-07 2017-12-11T20:02:34Z Article http://purl.org/eprint/type/JournalArticle 0896-6273 1097-4199 http://hdl.handle.net/1721.1/112701 Madabhushi, Ram et al. “DNA Damage and Its Links to Neurodegeneration.” Neuron 83, 2 (July 2014): 266–282 © 2014 Elsevier Inc https://orcid.org/0000-0001-9947-9071 https://orcid.org/0000-0003-1262-0592 http://dx.doi.org/10.1016/j.neuron.2014.06.034 Neuron Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier/Cell Press PMC |
| spellingShingle | Madabhushi, Ram Pan, Ling Tsai, Li-Huei DNA Damage and Its Links to Neurodegeneration |
| title | DNA Damage and Its Links to Neurodegeneration |
| title_full | DNA Damage and Its Links to Neurodegeneration |
| title_fullStr | DNA Damage and Its Links to Neurodegeneration |
| title_full_unstemmed | DNA Damage and Its Links to Neurodegeneration |
| title_short | DNA Damage and Its Links to Neurodegeneration |
| title_sort | dna damage and its links to neurodegeneration |
| url | http://hdl.handle.net/1721.1/112701 https://orcid.org/0000-0001-9947-9071 https://orcid.org/0000-0003-1262-0592 |
| work_keys_str_mv | AT madabhushiram dnadamageanditslinkstoneurodegeneration AT panling dnadamageanditslinkstoneurodegeneration AT tsailihuei dnadamageanditslinkstoneurodegeneration |