DNA Damage and Its Links to Neurodegeneration

DNA Damage and Its Links to Neurodegeneration

The integrity of our genetic material is under constant attack from numerous endogenous and exogenous agents. The consequences of a defective DNA damage response are well studied in proliferating cells, especially with regards to the development of cancer, yet its precise roles in the nervous system...

Full description

Bibliographic Details
Main Authors:	Madabhushi, Ram, Pan, Ling, Tsai, Li-Huei
Other Authors:	Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Format:	Article
Published:	Elsevier/Cell Press 2017
Online Access:	http://hdl.handle.net/1721.1/112701 https://orcid.org/0000-0001-9947-9071 https://orcid.org/0000-0003-1262-0592

Similar Items

Linking Cell Cycle Reentry and DNA Damage in Neurodegeneration
by: Kim, Dohoon, et al.
Published: (2011)

Chromatin Regulation of DNA Damage Repair and Genome Integrity in the Central Nervous System
by: Pan, Ling, et al.
Published: (2017)

Walking the high wire: How neurons maintain stability in the crossline of neurodegeneration
by: Victor, Matheus B, et al.
Published: (2023)

Mechanisms of DNA damage‐mediated neurotoxicity in neurodegenerative disease
by: Welch, Gwyneth, et al.
Published: (2022)

S-nitrosation of proteins relevant to Alzheimer’s disease during early stages of neurodegeneration
by: Bhat, Vadiraja B., et al.
Published: (2017)

S-nitrosation of proteins relevant to Alzheimer's disease during early stages of neurodegeneration
by: Bhat, Vadiraja B., et al.
Published: (2017)

An epigenetic blockade of cognitive functions in the neurodegenerating brain
by: Rei, Damien, et al.
Published: (2015)

Neurons burdened by DNA double-strand breaks incite microglia activation through antiviral-like signaling in neurodegeneration
by: Welch, Gwyneth M, et al.
Published: (2023)

Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution
by: Hemberg, Martin, et al.
Published: (2017)

A Dietary Regimen of Caloric Restriction or Pharmacological Activation of SIRT1 to Delay the Onset of Neurodegeneration
by: Graeff, Johannes, et al.
Published: (2017)

Synaptic Deficits Are Rescued in the p25/Cdk5 Model of Neurodegeneration by the Reduction of beta-Secretase (BACE1)
by: Giusti-Rodriguez, Paola, et al.
Published: (2012)

Neurodegeneration in multiple sclerosis /
by: Filippi, Massimo, et al.
Published: (2007)

Phenotyping Neurodegeneration in Human iPSCs
by: Li, Jonathan, et al.
Published: (2021)

Phosphoproteomics identifies microglial Siglec‐F inflammatory response during neurodegeneration
by: Morshed, Nader, et al.
Published: (2021)

Chronic oxidative stress promotes GADD34-mediated phosphorylation of the TAR DNA-binding protein TDP-43, a modification linked to neurodegeneration
by: Goh, Catherine Wenhui, et al.
Published: (2018)

Thalamic neurodegeneration in multiple sclerosis.
by: Cifelli, A, et al.
Published: (2002)

Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes
by: Madabhushi, Ram, et al.
Published: (2017)

Links between the unfolded protein response and the DNA damage response in hypoxia
by: Ma, TS
Published: (2022)

From dietary excess to neurodegeneration: finding the missing links in vesicular autophagic transport degradation, and stress
by: Lim, Yu Jia
Published: (2015)

Regulation of biochemical pathways involved in neurodegeneration
by: Pooler, Amy Melissa
Published: (2006)

A magnetic resonance approach to neurodegeneration
by: Chen, Yin-Ching Iris
Published: (2009)

Inflammation versus neurodegeneration: consequences for treatment.
by: Palace, J
Published: (2007)

The contribution of inflammation to acute and chronic neurodegeneration.
by: Perry, V, et al.
Published: (1998)

Microglia states and nomenclature: A field at its crossroads
by: Tsai, Li-Huei
Published: (2023)

SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons
by: Dobbin, Matthew M., et al.
Published: (2016)

Thalamic neurodegeneration in relapsing: Remitting multiple sclerosis
by: Cifelli, A, et al.
Published: (2003)

Thalamic neurodegeneration in relapsing-remitting multiple sclerosis.
by: Wylezinska, M, et al.
Published: (2003)

Senataxin: genome guardian at the interface of transcription and neurodegeneration
by: Groh, M, et al.
Published: (2016)

Neurodegeneration in a marmoset model of multiple sclerosis
by: Pomeroy, I, et al.
Published: (2006)

Bioinformatics investigations on multi-omics datasets of neurodegeneration
by: Lim, Jolyn Jia Jia
Published: (2023)

The interplay between inflammation and neurodegeneration in CNS disease.
by: Esiri, M
Published: (2007)

Neurodegeneration behind bars: from molecules to jurisprudence
by: Sfera, A, et al.
Published: (2014)

The mitochondrial brain: From mitochondrial genome to neurodegeneration.
by: Turnbull, H, et al.
Published: (2010)

Role of senataxin in R-loop-mediated neurodegeneration
by: Kannan, A, et al.
Published: (2024)

Vascular smooth muscle cell dysfunction in neurodegeneration
by: Hayes, G, et al.
Published: (2022)

DNA damage recognition /
by: Siede, Wolfram, et al.
Published: (2006)

In the loop: how chromatin topology links genome structure to function in mechanisms underlying learning and memory
by: Watson, Lauren Ashley, et al.
Published: (2019)

HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer’s disease
by: Pao, Ping-Chieh, et al.
Published: (2021)

The Role of Epigenetic Mechanisms in the Regulation of Gene Expression in the Nervous System
by: Cholewa-Waclaw, Justyna, et al.
Published: (2017)

Blood biomarkers reveal progression of neurodegeneration using transcriptomic and proteomic datasets
by: Lim, Louis Li Jie
Published: (2024)