Amygdala inputs to prefrontal cortex guide behavior amid conflicting cues of reward and punishment
Orchestrating appropriate behavioral responses in the face of competing signals that predict either rewards or threats in the environment is crucial for survival. The basolateral nucleus of the amygdala (BLA) and prelimbic (PL) medial prefrontal cortex have been implicated in reward-seeking and fear...
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Published: |
Nature Publishing Group
2017
|
| Online Access: | http://hdl.handle.net/1721.1/112705 https://orcid.org/0000-0003-4327-1102 https://orcid.org/0000-0003-0652-5652 https://orcid.org/0000-0002-1410-8675 https://orcid.org/0000-0003-2527-3382 https://orcid.org/0000-0003-2867-654X https://orcid.org/0000-0003-2371-5706 |
| _version_ | 1826188287454216192 |
|---|---|
| author | Burgos-Robles, Anthony Noel Kimchi, Eyal Yaacov Izadmehr, Ehsan Porzenheim, Mary Jane Ramos-Guasp, William A Nieh, Edward H Felix-Ortiz, Ada Namburi, Praneeth Leppla, Christopher Albert Presbrey, Kara N. Anandalingam, Kavitha Pagan-Rivera, Pablo A Anahtar, Melodi N. Beyeler, Anna Tye, Kay M |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Burgos-Robles, Anthony Noel Kimchi, Eyal Yaacov Izadmehr, Ehsan Porzenheim, Mary Jane Ramos-Guasp, William A Nieh, Edward H Felix-Ortiz, Ada Namburi, Praneeth Leppla, Christopher Albert Presbrey, Kara N. Anandalingam, Kavitha Pagan-Rivera, Pablo A Anahtar, Melodi N. Beyeler, Anna Tye, Kay M |
| author_sort | Burgos-Robles, Anthony Noel |
| collection | MIT |
| description | Orchestrating appropriate behavioral responses in the face of competing signals that predict either rewards or threats in the environment is crucial for survival. The basolateral nucleus of the amygdala (BLA) and prelimbic (PL) medial prefrontal cortex have been implicated in reward-seeking and fear-related responses, but how information flows between these reciprocally connected structures to coordinate behavior is unknown. We recorded neuronal activity from the BLA and PL while rats performed a task wherein competing shock- and sucrose-predictive cues were simultaneously presented. The correlated firing primarily displayed a BLA→PL directionality during the shock-associated cue. Furthermore, BLA neurons optogenetically identified as projecting to PL more accurately predicted behavioral responses during competition than unidentified BLA neurons. Finally photostimulation of the BLA→PL projection increased freezing, whereas both chemogenetic and optogenetic inhibition reduced freezing. Therefore, the BLA→PL circuit is critical in governing the selection of behavioral responses in the face of competing signals. |
| first_indexed | 2024-09-23T07:57:03Z |
| format | Article |
| id | mit-1721.1/112705 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T07:57:03Z |
| publishDate | 2017 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | mit-1721.1/1127052022-09-30T01:15:27Z Amygdala inputs to prefrontal cortex guide behavior amid conflicting cues of reward and punishment Burgos-Robles, Anthony Noel Kimchi, Eyal Yaacov Izadmehr, Ehsan Porzenheim, Mary Jane Ramos-Guasp, William A Nieh, Edward H Felix-Ortiz, Ada Namburi, Praneeth Leppla, Christopher Albert Presbrey, Kara N. Anandalingam, Kavitha Pagan-Rivera, Pablo A Anahtar, Melodi N. Beyeler, Anna Tye, Kay M Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Picower Institute for Learning and Memory Burgos-Robles, Anthony Noel Kimchi, Eyal Yaacov Izadmehr, Ehsan Porzenheim, Mary Jane Ramos-Guasp, William A Nieh, Edward H Felix-Ortiz, Ada Namburi, Praneeth Leppla, Christopher Albert Presbrey, Kara N. Anandalingam, Kavitha Pagan-Rivera, Pablo A Anahtar, Melodi N. Beyeler, Anna Tye, Kay M Orchestrating appropriate behavioral responses in the face of competing signals that predict either rewards or threats in the environment is crucial for survival. The basolateral nucleus of the amygdala (BLA) and prelimbic (PL) medial prefrontal cortex have been implicated in reward-seeking and fear-related responses, but how information flows between these reciprocally connected structures to coordinate behavior is unknown. We recorded neuronal activity from the BLA and PL while rats performed a task wherein competing shock- and sucrose-predictive cues were simultaneously presented. The correlated firing primarily displayed a BLA→PL directionality during the shock-associated cue. Furthermore, BLA neurons optogenetically identified as projecting to PL more accurately predicted behavioral responses during competition than unidentified BLA neurons. Finally photostimulation of the BLA→PL projection increased freezing, whereas both chemogenetic and optogenetic inhibition reduced freezing. Therefore, the BLA→PL circuit is critical in governing the selection of behavioral responses in the face of competing signals. National Institutes of Health (U.S.) (Award 1R25-MH092912-01) National Institute of Mental Health (U.S.) (Grant R01- MH102441-01) National Institutes of Health (U.S.) (Award DP2- DK-102256-01) 2017-12-12T15:16:13Z 2017-12-12T15:16:13Z 2017-04 2017-12-11T21:34:35Z Article http://purl.org/eprint/type/JournalArticle 1097-6256 1546-1726 http://hdl.handle.net/1721.1/112705 Burgos-Robles, Anthony et al. “Amygdala Inputs to Prefrontal Cortex Guide Behavior Amid Conflicting Cues of Reward and Punishment.” Nature Neuroscience 20, 6 (April 2017): 824–835 © 2017 Nature America, Inc., part of Springer Nature https://orcid.org/0000-0003-4327-1102 https://orcid.org/0000-0003-0652-5652 https://orcid.org/0000-0002-1410-8675 https://orcid.org/0000-0003-2527-3382 https://orcid.org/0000-0003-2867-654X https://orcid.org/0000-0003-2371-5706 http://dx.doi.org/10.1038/nn.4553 Nature Neuroscience Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Nature Publishing Group PMC |
| spellingShingle | Burgos-Robles, Anthony Noel Kimchi, Eyal Yaacov Izadmehr, Ehsan Porzenheim, Mary Jane Ramos-Guasp, William A Nieh, Edward H Felix-Ortiz, Ada Namburi, Praneeth Leppla, Christopher Albert Presbrey, Kara N. Anandalingam, Kavitha Pagan-Rivera, Pablo A Anahtar, Melodi N. Beyeler, Anna Tye, Kay M Amygdala inputs to prefrontal cortex guide behavior amid conflicting cues of reward and punishment |
| title | Amygdala inputs to prefrontal cortex guide behavior amid conflicting cues of reward and punishment |
| title_full | Amygdala inputs to prefrontal cortex guide behavior amid conflicting cues of reward and punishment |
| title_fullStr | Amygdala inputs to prefrontal cortex guide behavior amid conflicting cues of reward and punishment |
| title_full_unstemmed | Amygdala inputs to prefrontal cortex guide behavior amid conflicting cues of reward and punishment |
| title_short | Amygdala inputs to prefrontal cortex guide behavior amid conflicting cues of reward and punishment |
| title_sort | amygdala inputs to prefrontal cortex guide behavior amid conflicting cues of reward and punishment |
| url | http://hdl.handle.net/1721.1/112705 https://orcid.org/0000-0003-4327-1102 https://orcid.org/0000-0003-0652-5652 https://orcid.org/0000-0002-1410-8675 https://orcid.org/0000-0003-2527-3382 https://orcid.org/0000-0003-2867-654X https://orcid.org/0000-0003-2371-5706 |
| work_keys_str_mv | AT burgosroblesanthonynoel amygdalainputstoprefrontalcortexguidebehavioramidconflictingcuesofrewardandpunishment AT kimchieyalyaacov amygdalainputstoprefrontalcortexguidebehavioramidconflictingcuesofrewardandpunishment AT izadmehrehsan amygdalainputstoprefrontalcortexguidebehavioramidconflictingcuesofrewardandpunishment AT porzenheimmaryjane amygdalainputstoprefrontalcortexguidebehavioramidconflictingcuesofrewardandpunishment AT ramosguaspwilliama amygdalainputstoprefrontalcortexguidebehavioramidconflictingcuesofrewardandpunishment AT niehedwardh amygdalainputstoprefrontalcortexguidebehavioramidconflictingcuesofrewardandpunishment AT felixortizada amygdalainputstoprefrontalcortexguidebehavioramidconflictingcuesofrewardandpunishment AT namburipraneeth amygdalainputstoprefrontalcortexguidebehavioramidconflictingcuesofrewardandpunishment AT lepplachristopheralbert amygdalainputstoprefrontalcortexguidebehavioramidconflictingcuesofrewardandpunishment AT presbreykaran amygdalainputstoprefrontalcortexguidebehavioramidconflictingcuesofrewardandpunishment AT anandalingamkavitha amygdalainputstoprefrontalcortexguidebehavioramidconflictingcuesofrewardandpunishment AT paganriverapabloa amygdalainputstoprefrontalcortexguidebehavioramidconflictingcuesofrewardandpunishment AT anahtarmelodin amygdalainputstoprefrontalcortexguidebehavioramidconflictingcuesofrewardandpunishment AT beyeleranna amygdalainputstoprefrontalcortexguidebehavioramidconflictingcuesofrewardandpunishment AT tyekaym amygdalainputstoprefrontalcortexguidebehavioramidconflictingcuesofrewardandpunishment |