Inhibitory Input from the Lateral Hypothalamus to the Ventral Tegmental Area Disinhibits Dopamine Neurons and Promotes Behavioral Activation
Projections from the lateral hypothalamus (LH) to the ventral tegmental area (VTA), containing both GABAergic and glutamatergic components, encode conditioned responses and control compulsive reward-seeking behavior. GABAergic neurons in the LH have been shown to mediate appetitive and feeding-relat...
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| Format: | Article |
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Elsevier/Cell Press
2017
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| Online Access: | http://hdl.handle.net/1721.1/112706 https://orcid.org/0000-0003-2154-6224 https://orcid.org/0000-0002-8269-2615 https://orcid.org/0000-0001-6754-0333 https://orcid.org/0000-0002-4506-8813 https://orcid.org/0000-0003-2527-3382 |
| _version_ | 1811079714116206592 |
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| author | Nieh, Horng-An Edward Vander Weele, Caitlin Miya Matthews, Gillian Ac Presbrey, Kara N. Wichmann, Romy Leppla, Christopher Albert Izadmehr, Ehsan Tye, Kay M |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Nieh, Horng-An Edward Vander Weele, Caitlin Miya Matthews, Gillian Ac Presbrey, Kara N. Wichmann, Romy Leppla, Christopher Albert Izadmehr, Ehsan Tye, Kay M |
| author_sort | Nieh, Horng-An Edward |
| collection | MIT |
| description | Projections from the lateral hypothalamus (LH) to the ventral tegmental area (VTA), containing both GABAergic and glutamatergic components, encode conditioned responses and control compulsive reward-seeking behavior. GABAergic neurons in the LH have been shown to mediate appetitive and feeding-related behaviors. Here we show that the GABAergic component of the LH-VTA pathway supports positive reinforcement and place preference, while the glutamatergic component mediates place avoidance. In addition, our results indicate that photoactivation of these projections modulates other behaviors, such as social interaction and perseverant investigation of a novel object. We provide evidence that photostimulation of the GABAergic LH-VTA component, but not the glutamatergic component, increases dopamine (DA) release in the nucleus accumbens (NAc) via inhibition of local VTA GABAergic neurons. Our study clarifies how GABAergic LH inputs to the VTA can contribute to generalized behavioral activation across multiple contexts, consistent with a role in increasing motivational salience. |
| first_indexed | 2024-09-23T11:19:23Z |
| format | Article |
| id | mit-1721.1/112706 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T11:19:23Z |
| publishDate | 2017 |
| publisher | Elsevier/Cell Press |
| record_format | dspace |
| spelling | mit-1721.1/1127062022-10-01T02:48:05Z Inhibitory Input from the Lateral Hypothalamus to the Ventral Tegmental Area Disinhibits Dopamine Neurons and Promotes Behavioral Activation Nieh, Horng-An Edward Vander Weele, Caitlin Miya Matthews, Gillian Ac Presbrey, Kara N. Wichmann, Romy Leppla, Christopher Albert Izadmehr, Ehsan Tye, Kay M Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Picower Institute for Learning and Memory Nieh, Horng-An Edward Vander Weele, Caitlin Miya Matthews, Gillian Ac Presbrey, Kara N. Wichmann, Romy Leppla, Christopher Albert Izadmehr, Ehsan Tye, Kay M Projections from the lateral hypothalamus (LH) to the ventral tegmental area (VTA), containing both GABAergic and glutamatergic components, encode conditioned responses and control compulsive reward-seeking behavior. GABAergic neurons in the LH have been shown to mediate appetitive and feeding-related behaviors. Here we show that the GABAergic component of the LH-VTA pathway supports positive reinforcement and place preference, while the glutamatergic component mediates place avoidance. In addition, our results indicate that photoactivation of these projections modulates other behaviors, such as social interaction and perseverant investigation of a novel object. We provide evidence that photostimulation of the GABAergic LH-VTA component, but not the glutamatergic component, increases dopamine (DA) release in the nucleus accumbens (NAc) via inhibition of local VTA GABAergic neurons. Our study clarifies how GABAergic LH inputs to the VTA can contribute to generalized behavioral activation across multiple contexts, consistent with a role in increasing motivational salience. National Institute of Mental Health (U.S.) (Grant R01-MH102441-01) 2017-12-12T15:22:56Z 2017-12-12T15:22:56Z 2016-05 2016-03 2017-12-11T21:37:54Z Article http://purl.org/eprint/type/JournalArticle 0896-6273 1097-4199 http://hdl.handle.net/1721.1/112706 Nieh, Edward H. et al. “Inhibitory Input from the Lateral Hypothalamus to the Ventral Tegmental Area Disinhibits Dopamine Neurons and Promotes Behavioral Activation.” Neuron 90, 6 (June 2016): 1286–1298 © 2016 Elsevier Inc https://orcid.org/0000-0003-2154-6224 https://orcid.org/0000-0002-8269-2615 https://orcid.org/0000-0001-6754-0333 https://orcid.org/0000-0002-4506-8813 https://orcid.org/0000-0003-2527-3382 http://dx.doi.org/10.1016/J.NEURON.2016.04.035 Neuron Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier/Cell Press PMC |
| spellingShingle | Nieh, Horng-An Edward Vander Weele, Caitlin Miya Matthews, Gillian Ac Presbrey, Kara N. Wichmann, Romy Leppla, Christopher Albert Izadmehr, Ehsan Tye, Kay M Inhibitory Input from the Lateral Hypothalamus to the Ventral Tegmental Area Disinhibits Dopamine Neurons and Promotes Behavioral Activation |
| title | Inhibitory Input from the Lateral Hypothalamus to the Ventral Tegmental Area Disinhibits Dopamine Neurons and Promotes Behavioral Activation |
| title_full | Inhibitory Input from the Lateral Hypothalamus to the Ventral Tegmental Area Disinhibits Dopamine Neurons and Promotes Behavioral Activation |
| title_fullStr | Inhibitory Input from the Lateral Hypothalamus to the Ventral Tegmental Area Disinhibits Dopamine Neurons and Promotes Behavioral Activation |
| title_full_unstemmed | Inhibitory Input from the Lateral Hypothalamus to the Ventral Tegmental Area Disinhibits Dopamine Neurons and Promotes Behavioral Activation |
| title_short | Inhibitory Input from the Lateral Hypothalamus to the Ventral Tegmental Area Disinhibits Dopamine Neurons and Promotes Behavioral Activation |
| title_sort | inhibitory input from the lateral hypothalamus to the ventral tegmental area disinhibits dopamine neurons and promotes behavioral activation |
| url | http://hdl.handle.net/1721.1/112706 https://orcid.org/0000-0003-2154-6224 https://orcid.org/0000-0002-8269-2615 https://orcid.org/0000-0001-6754-0333 https://orcid.org/0000-0002-4506-8813 https://orcid.org/0000-0003-2527-3382 |
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