Transcription control by the ENL YEATS domain in acute leukaemia

Transcription control by the ENL YEATS domain in acute leukaemia

Recurrent chromosomal translocations producing a chimaeric MLL oncogene give rise to a highly aggressive acute leukaemia associated with poor clinical outcome. The preferential involvement of chromatin-associated factors as MLL fusion partners belies a dependency on transcription control. Despite re...

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Bibliographic Details
Main Authors: Erb, Michael A., Scott, Thomas G., Li, Bin E., Xie, Huafeng, Paulk, Joshiawa, Seo, Hyuk-Soo, Souza, Amanda, Roberts, Justin M., Dastjerdi, Shiva, Buckley, Dennis L., Nabet, Behnam, Zeid, Rhamy, Offei-Addo, Nana K., Dhe-Paganon, Sirano, Orkin, Stuart H., Winter, Georg E., Bradner, James E., Sanjana, Neville E, Shalem, Ophir, Zhang, Feng
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Published: Nature Publishing Group 2017
Online Access:http://hdl.handle.net/1721.1/112743
https://orcid.org/0000-0003-2782-2509

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