Kinetically selective inhibitors of histone deacetylase 2 (HDAC2) as cognition enhancers

Kinetically selective inhibitors of histone deacetylase 2 (HDAC2) as cognition enhancers

Aiming towards the development of novel nootropic therapeutics to address the cognitive impairment common to a range of brain disorders, we set out to develop highly selective small molecule inhibitors of HDAC2, a chromatin modifying histone deacetylase implicated in memory formation and synaptic p...

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Bibliographic Details
Main Authors: Wagner, F. F., Zhang, Y.-L., Fass, D. M., Gale, J. P., Weïwer, M., McCarren, P., Fisher, S. L., Kaya, T., Zhao, W.-N., Reis, S. A., Hennig, K. M., Thomas, M., Lemercier, B. C., Lewis, M. C., Moyer, M. P., Scolnick, E., Haggarty, S. J., Holson, E. B., Joseph, Nadine, Guan, Jisong, Tsai, Li-Huei
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Format: Article
Published: Royal Society of Chemistry (RSC) 2017
Online Access:http://hdl.handle.net/1721.1/112747
https://orcid.org/0000-0003-1262-0592

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