Arterial Remodeling and Endothelial Shear Stress Exhibit Significant Longitudinal Heterogeneity Along the Length of Coronary Plaques
Atherosclerosis is determined by both systemic risk factors and local vascular mechanisms. The arterial remodeling in response to plaque development plays a key role in atherosclerosis. Compensatory expansive remodeling is an adaptive mechanism that maintains lumen patency as a plaque develops. In c...
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| Format: | Article |
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Elsevier
2017
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| Online Access: | http://hdl.handle.net/1721.1/112775 https://orcid.org/0000-0002-7832-7156 |
| _version_ | 1811097130377412608 |
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| author | Antoniadis, Antonios P. Papafaklis, Michail I. Takahashi, Saeko Shishido, Koki Andreou, Ioannis Chatzizisis, Yiannis S. Tsuda, Masaya Mizuno, Shingo Makita, Yasuhiro Domei, Takenori Ikemoto, Tomokazu Coskun, Ahmet U. Honye, Junko Nakamura, Shigeru Saito, Shigeru Feldman, Charles L. Stone, Peter H. Edelman, Elazer R |
| author2 | Massachusetts Institute of Technology. Institute for Medical Engineering & Science |
| author_facet | Massachusetts Institute of Technology. Institute for Medical Engineering & Science Antoniadis, Antonios P. Papafaklis, Michail I. Takahashi, Saeko Shishido, Koki Andreou, Ioannis Chatzizisis, Yiannis S. Tsuda, Masaya Mizuno, Shingo Makita, Yasuhiro Domei, Takenori Ikemoto, Tomokazu Coskun, Ahmet U. Honye, Junko Nakamura, Shigeru Saito, Shigeru Feldman, Charles L. Stone, Peter H. Edelman, Elazer R |
| author_sort | Antoniadis, Antonios P. |
| collection | MIT |
| description | Atherosclerosis is determined by both systemic risk factors and local vascular mechanisms. The arterial remodeling in response to plaque development plays a key role in atherosclerosis. Compensatory expansive remodeling is an adaptive mechanism that maintains lumen patency as a plaque develops. In contrast, excessive expansive remodeling, signifying an enlargement in vascular and lumen volume as a result of local plaque buildup, is a consistent attribute of high-risk plaques. Local hemodynamic factors, in particular low endothelial shear stress (ESS), is an intensely proinflammatory and proatherogenic stimulus and largely accounts for the spatially diverse distribution of atherosclerotic plaques. However, plaque, remodeling and ESS have hitherto been investigated only in the cross-sectional arterial axis and their distribution in the longitudinal axis of individual plaques has not been characterized. |
| first_indexed | 2024-09-23T16:54:49Z |
| format | Article |
| id | mit-1721.1/112775 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T16:54:49Z |
| publishDate | 2017 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/1127752022-10-03T09:07:28Z Arterial Remodeling and Endothelial Shear Stress Exhibit Significant Longitudinal Heterogeneity Along the Length of Coronary Plaques Antoniadis, Antonios P. Papafaklis, Michail I. Takahashi, Saeko Shishido, Koki Andreou, Ioannis Chatzizisis, Yiannis S. Tsuda, Masaya Mizuno, Shingo Makita, Yasuhiro Domei, Takenori Ikemoto, Tomokazu Coskun, Ahmet U. Honye, Junko Nakamura, Shigeru Saito, Shigeru Feldman, Charles L. Stone, Peter H. Edelman, Elazer R Massachusetts Institute of Technology. Institute for Medical Engineering & Science Edelman, Elazer R Atherosclerosis is determined by both systemic risk factors and local vascular mechanisms. The arterial remodeling in response to plaque development plays a key role in atherosclerosis. Compensatory expansive remodeling is an adaptive mechanism that maintains lumen patency as a plaque develops. In contrast, excessive expansive remodeling, signifying an enlargement in vascular and lumen volume as a result of local plaque buildup, is a consistent attribute of high-risk plaques. Local hemodynamic factors, in particular low endothelial shear stress (ESS), is an intensely proinflammatory and proatherogenic stimulus and largely accounts for the spatially diverse distribution of atherosclerotic plaques. However, plaque, remodeling and ESS have hitherto been investigated only in the cross-sectional arterial axis and their distribution in the longitudinal axis of individual plaques has not been characterized. 2017-12-18T14:32:53Z 2017-12-18T14:32:53Z 2016-08 2017-12-14T19:23:58Z Article http://purl.org/eprint/type/JournalArticle 1936-878X http://hdl.handle.net/1721.1/112775 Antoniadis, Antonios P. et al. “Arterial Remodeling and Endothelial Shear Stress Exhibit Significant Longitudinal Heterogeneity Along the Length of Coronary Plaques.” JACC: Cardiovascular Imaging 9, 8 (August 2016): 1007–1009 © 2016 American College of Cardiology Foundation https://orcid.org/0000-0002-7832-7156 http://dx.doi.org/10.1016/J.JCMG.2016.04.003 JACC: Cardiovascular Imaging Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier PMC |
| spellingShingle | Antoniadis, Antonios P. Papafaklis, Michail I. Takahashi, Saeko Shishido, Koki Andreou, Ioannis Chatzizisis, Yiannis S. Tsuda, Masaya Mizuno, Shingo Makita, Yasuhiro Domei, Takenori Ikemoto, Tomokazu Coskun, Ahmet U. Honye, Junko Nakamura, Shigeru Saito, Shigeru Feldman, Charles L. Stone, Peter H. Edelman, Elazer R Arterial Remodeling and Endothelial Shear Stress Exhibit Significant Longitudinal Heterogeneity Along the Length of Coronary Plaques |
| title | Arterial Remodeling and Endothelial Shear Stress Exhibit Significant Longitudinal Heterogeneity Along the Length of Coronary Plaques |
| title_full | Arterial Remodeling and Endothelial Shear Stress Exhibit Significant Longitudinal Heterogeneity Along the Length of Coronary Plaques |
| title_fullStr | Arterial Remodeling and Endothelial Shear Stress Exhibit Significant Longitudinal Heterogeneity Along the Length of Coronary Plaques |
| title_full_unstemmed | Arterial Remodeling and Endothelial Shear Stress Exhibit Significant Longitudinal Heterogeneity Along the Length of Coronary Plaques |
| title_short | Arterial Remodeling and Endothelial Shear Stress Exhibit Significant Longitudinal Heterogeneity Along the Length of Coronary Plaques |
| title_sort | arterial remodeling and endothelial shear stress exhibit significant longitudinal heterogeneity along the length of coronary plaques |
| url | http://hdl.handle.net/1721.1/112775 https://orcid.org/0000-0002-7832-7156 |
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