Proton-pump inhibitor use is associated with low serum magnesium concentrations
Although case reports link proton-pump inhibitor (PPI) use and hypomagnesemia, no large-scale studies have been conducted. Here we examined the serum magnesium concentration and the likelihood of hypomagnesemia ( < 1.6 mg/dl) with a history of PPI or histamine-2 receptor antagonist used to reduce...
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Nature Publishing Group
2017
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| Online Access: | http://hdl.handle.net/1721.1/112807 https://orcid.org/0000-0001-8593-9321 https://orcid.org/0000-0002-6318-2978 |
| _version_ | 1826189649520885760 |
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| author | Danziger, John William, Jeffrey H. Howell, Michael D. Mukamal, Kenneth J. Scott, Daniel Lee, Joonwu Lehman, Li-Wei Mark, Roger G Celi, Leo Anthony G. |
| author2 | Massachusetts Institute of Technology. Institute for Medical Engineering & Science |
| author_facet | Massachusetts Institute of Technology. Institute for Medical Engineering & Science Danziger, John William, Jeffrey H. Howell, Michael D. Mukamal, Kenneth J. Scott, Daniel Lee, Joonwu Lehman, Li-Wei Mark, Roger G Celi, Leo Anthony G. |
| author_sort | Danziger, John |
| collection | MIT |
| description | Although case reports link proton-pump inhibitor (PPI) use and hypomagnesemia, no large-scale studies have been conducted. Here we examined the serum magnesium concentration and the likelihood of hypomagnesemia ( < 1.6 mg/dl) with a history of PPI or histamine-2 receptor antagonist used to reduce gastric acid, or use of neither among 11,490 consecutive adult admissions to an intensive care unit of a tertiary medical center. Of these, 2632 patients reported PPI use prior to admission, while 657 patients were using a histamine-2 receptor antagon ist. PPI use was associated with 0.012 mg/dl lower adjusted serum magnesium concentration compared to users of no acid-suppressive medications, but this effect was restricted to those patients taking diuretics. Among the 3286 patients concurrently on diuretics, PPI use was associated with a significant increase of hypomagnesemia (odds ratio 1.54) and 0.028 mg/dl lower serum magnesium concentration. Among those not using diuretics, PPI use was not associated with serum magnesium levels. Histamine-2 receptor antagonist use was not significantly associated with magnesium concentration without or with diuretic use. The use of PPI was not associated with serum phosphate concentration regardless of diuretic use. Thus, we verify case reports of the association between PPI use and hypomagnesemia in those concurrently taking diuretics. Hence, serum magnesium concentrations should be followed in susceptible individuals on chronic PPI therapy. |
| first_indexed | 2024-09-23T08:18:58Z |
| format | Article |
| id | mit-1721.1/112807 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T08:18:58Z |
| publishDate | 2017 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | mit-1721.1/1128072024-03-20T19:38:44Z Proton-pump inhibitor use is associated with low serum magnesium concentrations Danziger, John William, Jeffrey H. Howell, Michael D. Mukamal, Kenneth J. Scott, Daniel Lee, Joonwu Lehman, Li-Wei Mark, Roger G Celi, Leo Anthony G. Massachusetts Institute of Technology. Institute for Medical Engineering & Science Harvard University--MIT Division of Health Sciences and Technology Scott, Daniel Lee, Joonwu Lehman, Li-Wei Mark, Roger G Celi, Leo Anthony G. Although case reports link proton-pump inhibitor (PPI) use and hypomagnesemia, no large-scale studies have been conducted. Here we examined the serum magnesium concentration and the likelihood of hypomagnesemia ( < 1.6 mg/dl) with a history of PPI or histamine-2 receptor antagonist used to reduce gastric acid, or use of neither among 11,490 consecutive adult admissions to an intensive care unit of a tertiary medical center. Of these, 2632 patients reported PPI use prior to admission, while 657 patients were using a histamine-2 receptor antagon ist. PPI use was associated with 0.012 mg/dl lower adjusted serum magnesium concentration compared to users of no acid-suppressive medications, but this effect was restricted to those patients taking diuretics. Among the 3286 patients concurrently on diuretics, PPI use was associated with a significant increase of hypomagnesemia (odds ratio 1.54) and 0.028 mg/dl lower serum magnesium concentration. Among those not using diuretics, PPI use was not associated with serum magnesium levels. Histamine-2 receptor antagonist use was not significantly associated with magnesium concentration without or with diuretic use. The use of PPI was not associated with serum phosphate concentration regardless of diuretic use. Thus, we verify case reports of the association between PPI use and hypomagnesemia in those concurrently taking diuretics. Hence, serum magnesium concentrations should be followed in susceptible individuals on chronic PPI therapy. National Institute of Biomedical Imaging and Bioengineering (U.S.) (Grant 2R01 EB001659) 2017-12-19T18:35:02Z 2017-12-19T18:35:02Z 2015-12 2012-10 2017-12-19T15:54:03Z Article http://purl.org/eprint/type/JournalArticle 0085-2538 1523-1755 http://hdl.handle.net/1721.1/112807 Danziger, John, et al. “Proton-Pump Inhibitor Use Is Associated with Low Serum Magnesium Concentrations.” Kidney International 83, 4 (April 2013): 692–699. © 2013 International Society of Nephrology https://orcid.org/0000-0001-8593-9321 https://orcid.org/0000-0002-6318-2978 http://dx.doi.org/10.1038/ki.2012.452 Kidney International Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Nature Publishing Group PMC |
| spellingShingle | Danziger, John William, Jeffrey H. Howell, Michael D. Mukamal, Kenneth J. Scott, Daniel Lee, Joonwu Lehman, Li-Wei Mark, Roger G Celi, Leo Anthony G. Proton-pump inhibitor use is associated with low serum magnesium concentrations |
| title | Proton-pump inhibitor use is associated with low serum magnesium concentrations |
| title_full | Proton-pump inhibitor use is associated with low serum magnesium concentrations |
| title_fullStr | Proton-pump inhibitor use is associated with low serum magnesium concentrations |
| title_full_unstemmed | Proton-pump inhibitor use is associated with low serum magnesium concentrations |
| title_short | Proton-pump inhibitor use is associated with low serum magnesium concentrations |
| title_sort | proton pump inhibitor use is associated with low serum magnesium concentrations |
| url | http://hdl.handle.net/1721.1/112807 https://orcid.org/0000-0001-8593-9321 https://orcid.org/0000-0002-6318-2978 |
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