Obesity, Acute Kidney Injury, and Mortality in Critical Illness
Objectives: Although obesity is associated with risk for chronic kidney disease and improved survival, less is known about the associations of obesity with risk of acute kidney injury and post acute kidney injury mortality. Design: In a single-center inception cohort of almost 15,000 critically ill...
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Wolters Kluwer - Lippincott Williams & Wilkins
2017
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| Online Access: | http://hdl.handle.net/1721.1/112812 https://orcid.org/0000-0001-8593-9321 https://orcid.org/0000-0002-6318-2978 |
| _version_ | 1826204752018407424 |
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| author | Danziger, John Chen, Ken P. Mukamal, Kenneth J. Lee, Joonwu Feng, Mengling Celi, Leo Anthony G. Mark, Roger G |
| author2 | Institute for Medical Engineering and Science |
| author_facet | Institute for Medical Engineering and Science Danziger, John Chen, Ken P. Mukamal, Kenneth J. Lee, Joonwu Feng, Mengling Celi, Leo Anthony G. Mark, Roger G |
| author_sort | Danziger, John |
| collection | MIT |
| description | Objectives: Although obesity is associated with risk for chronic kidney disease and improved survival, less is known about the associations of obesity with risk of acute kidney injury and post acute kidney injury mortality. Design: In a single-center inception cohort of almost 15,000 critically ill patients, we evaluated the association of obesity with acute kidney injury and acute kidney injury severity, as well as in-hospital and 1-year survival. Acute kidney injury was defined using the Kidney Disease Outcome Quality Initiative criteria. Measurements and Main Results: The acute kidney injury prevalence rates for normal, overweight, class I, II, and III obesity were 18.6%, 20.6%, 22.5%, 24.3%, and 24.0%, respectively, and the adjusted odds ratios of acute kidney injury were 1.18 (95% CI, 1.06-1.31), 1.35 (1.19-1.53), 1.47 (1.25-1.73), and 1.59 (1.31-1.87) when compared with normal weight, respectively. Each 5-kg/m 2 increase in body mass index was associated with a 10% risk (95% CI, 1.06-1.24; p < 0.001) of more severe acute kidney injury. Within-hospital and 1-year survival rates associated with the acute kidney injury episodes were similar across body mass index categories. Conclusion: Obesity is a risk factor for acute kidney injury, which is associated with increased short-and long-term mortality. |
| first_indexed | 2024-09-23T13:00:51Z |
| format | Article |
| id | mit-1721.1/112812 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T13:00:51Z |
| publishDate | 2017 |
| publisher | Wolters Kluwer - Lippincott Williams & Wilkins |
| record_format | dspace |
| spelling | mit-1721.1/1128122022-09-28T11:27:37Z Obesity, Acute Kidney Injury, and Mortality in Critical Illness Danziger, John Chen, Ken P. Mukamal, Kenneth J. Lee, Joonwu Feng, Mengling Celi, Leo Anthony G. Mark, Roger G Institute for Medical Engineering and Science Harvard University--MIT Division of Health Sciences and Technology Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Lee, Joonwu Feng, Mengling Celi, Leo Anthony G. Mark, Roger G Objectives: Although obesity is associated with risk for chronic kidney disease and improved survival, less is known about the associations of obesity with risk of acute kidney injury and post acute kidney injury mortality. Design: In a single-center inception cohort of almost 15,000 critically ill patients, we evaluated the association of obesity with acute kidney injury and acute kidney injury severity, as well as in-hospital and 1-year survival. Acute kidney injury was defined using the Kidney Disease Outcome Quality Initiative criteria. Measurements and Main Results: The acute kidney injury prevalence rates for normal, overweight, class I, II, and III obesity were 18.6%, 20.6%, 22.5%, 24.3%, and 24.0%, respectively, and the adjusted odds ratios of acute kidney injury were 1.18 (95% CI, 1.06-1.31), 1.35 (1.19-1.53), 1.47 (1.25-1.73), and 1.59 (1.31-1.87) when compared with normal weight, respectively. Each 5-kg/m 2 increase in body mass index was associated with a 10% risk (95% CI, 1.06-1.24; p < 0.001) of more severe acute kidney injury. Within-hospital and 1-year survival rates associated with the acute kidney injury episodes were similar across body mass index categories. Conclusion: Obesity is a risk factor for acute kidney injury, which is associated with increased short-and long-term mortality. National Institute of Biomedical Imaging and Bioengineering (U.S.) (Grant 2R01 EB001659) National Institutes of Health (U.S.) (Grant R01-EB001659) 2017-12-19T20:37:04Z 2017-12-19T20:37:04Z 2016-02 2017-12-19T15:26:10Z Article http://purl.org/eprint/type/JournalArticle 0090-3493 http://hdl.handle.net/1721.1/112812 Danziger, John et al. “Obesity, Acute Kidney Injury, and Mortality in Critical Illness.” Critical Care Medicine 44, 2 (February 2016): 328–334 © 2015 by the Society of Critical Care Medicine and Wolters Kluwer Health, Inc https://orcid.org/0000-0001-8593-9321 https://orcid.org/0000-0002-6318-2978 http://dx.doi.org/10.1097/CCM.0000000000001398 Critical Care Medicine Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Wolters Kluwer - Lippincott Williams & Wilkins PMC |
| spellingShingle | Danziger, John Chen, Ken P. Mukamal, Kenneth J. Lee, Joonwu Feng, Mengling Celi, Leo Anthony G. Mark, Roger G Obesity, Acute Kidney Injury, and Mortality in Critical Illness |
| title | Obesity, Acute Kidney Injury, and Mortality in Critical Illness |
| title_full | Obesity, Acute Kidney Injury, and Mortality in Critical Illness |
| title_fullStr | Obesity, Acute Kidney Injury, and Mortality in Critical Illness |
| title_full_unstemmed | Obesity, Acute Kidney Injury, and Mortality in Critical Illness |
| title_short | Obesity, Acute Kidney Injury, and Mortality in Critical Illness |
| title_sort | obesity acute kidney injury and mortality in critical illness |
| url | http://hdl.handle.net/1721.1/112812 https://orcid.org/0000-0001-8593-9321 https://orcid.org/0000-0002-6318-2978 |
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